CeGaT GmbH’s Post

🎥 New Video Alert! 🚀 We’re excited to share our latest research video from BioInsights Academy, hosted by Yasmin and Sara. In this episode, we delve into the LncRNA MALAT1/ microRNA-561-3p/TOP2A axis and its significant role in breast cancer progression. 🧬🧫 🔍 Key Highlights: The function of MALAT1 and miR-561-3p in gene regulation and cancer. Insights into how MALAT1 promotes malignancy and miR-561-3p acts as a tumor suppressor. Our findings on MALAT1 knockdown and its impact on cancer cell proliferation, apoptosis, and cell cycle arrest. 📚 Read the full article in Scientific Reports for more details. Watch the full video on our YouTube channel now: https://lnkd.in/gi_ddJeK #BioInsightsAcademy #CancerResearch #MALAT1 #miR561 #BreastCancer #ScientificResearch #Oncology #siRNA #Genetics #TOP2A #Cancer

Researchers have discovered a potential mechanism underpinning why a person's genome might influence the subtype of breast cancer they develop. Dr Kathleen Houlahan, lead researcher in the study, commented, “Our findings not only explain which subtype of breast cancer an individual is likely to develop but they also hint at how aggressive and prone to metastasising that subtype will be.” Hannah Flynn and Yan Lau write about this important research in BioNews: https://lnkd.in/eNcXr2WW Why not share your thoughts in the article comment section on our website. #breastcancer #cancer #BRCA1 #BRCA2 #cancerresearch #genomics #genetics #DNA

Exciting advancements in lung cancer treatment! This study explores the combination of PD-1 pathway blockade and chemotherapy for resectable lung cancer. Using spatial transcriptomics, researchers uncover patterns in the tumor microenvironment that predict treatment response. These insights could revolutionize personalized cancer therapy p/b Northwestern University, Massachusetts General Hospital, Jonathan H. Chen, Justin Gainor #LungCancer #CancerResearch #Immunotherapy https://lnkd.in/gnijbXbQ

#Organoids Reveal the Sequential Mutations Driving Adenoma-Carcinoma Transition. #ColonOrganoid By Nature Cancer. More Organoids Research Highlights: https://lnkd.in/ejGQ_sYh Article Link:  https://lnkd.in/eKGQ3QtK

A recent study conducted by investigators at Vanderbilt University Medical Center found that pathogenic variants of the WNT9B gene were associated with an increased risk of hereditary prostate cancer. According to senior author Jeffery R. Smith, MD, PhD, this association is comparable to that seen with pathogenic mutations in breast cancer. 🔗 Learn more here: https://lnkd.in/eYvhd2rV #PCSM

Read an exciting breakthrough in cancer research, recently highlighted in Nature (by Lorenzo-Martín). They have crafted a cutting-edge model of the human colon that mimics real-life conditions incredibly closely. They've engineered tiny 'mini-colons' that allow scientists to observe and understand how colon cancer develops, right from the first mutated cell. This innovative approach combines the precision of genetic engineering with 3D bioprinting, paving the way for incredible insights into how tumors form and progress. It's like having a high-definition movie of cancer evolution, offering researchers a front-row seat to see exactly how cancer behaves and responds to treatments. This could be a game-changer in developing more effective therapies, bringing new hope in the fight against cancer. https://lnkd.in/eT6UAGYU

It's been 30 years since the discovery of the BRCA1 variation! Cancer Research UK provides an insightful document tracing the history of BRCA genes, from their initial identification to the effectiveness of PARP inhibitors in patients with BRCA variations. Recent data highlights the cost-effectiveness of BRCA screening at a population level. How many of your patients undergo testing for BRCA variations? #BRCA #BREASTCANCER #Genetics #Unilabs Link to article: https://lnkd.in/e7PaPJVb

Looking forward to discussing our new CUT&RUN-based DNA methylation technology at the AACR Special Conference in San Diego! I'm particularly excited about how this approach can be used for whole-genome DNA methylation analysis using up to 40x less sequencing than current whole genome bisulfite sequencing (WGBS-seq). Potential game changer for single cell / spatial applications!

In India, cancer cases are on the rise. According to GLOBOCAN 2020, the number of new cancer... - http://toi.in/9BiINa via @timesofindia #Cancer #genetics #oncology #india #prevention #healthString www.sugarstrings.ai

Interesting talk by Roza Opperman at the #NPP2025 meeting. She talked about her research into discovering biomarkers for the diagnosis of colorectal cancer and adenocarcinoma. Exciting data including the use of metaproteomics and 16S rRNA profiling on the human microbiome.