Children's National Hospital’s Post

My fifth scientific publication as a principal author and my third with the distinguished French researcher, Professor Salima HACEIN-BEY-ABINA, an international pioneer in gene therapy who achieved the first therapeutic success with this approach. In this study, published in Frontiers in Immunology, we established a thorough comparison between two types of genetically modified immune cells, CAR-T and CAR-NK cells, in the treatment of hematological cancers. My thanks go to all the team: Salima HACEIN-BEY-ABINA, Andrada Chiron, Stéphanie Bessoles, and Guillaume Sarrabayrouse. 🔗 Link to the article: https://lnkd.in/gG_mQEWc #CancerResearch #Cancer #GeneTherapy

Did you know small RNA sequencing can identify biomarkers for disease diagnostics or classification, like for cancer? Small RNAs are involved in various functions, including RNA interference, gene silencing, and epigenetic modifications. By sequencing, we can determine the diverse expression of all small RNAs in a sample. Analyzing these expression profiles helps us to better understand dysregulation under pathological conditions and to identify key biomarkers in disease pathogenesis. Learn more here: https://lnkd.in/ecuYBZAe #smallRNA #sequencing #NGS

Looking for an advanced human in vitro liver model for your research? Check out our poster on "A comprehensive and scalable human liver-on-chip model for fibrosis drug discovery and gene delivery applications." MIMETAS's advanced 3D liver model mimics steatosis and fibrosis using multiple cell types (hepatocytes, endothelial, stellate, and immune cells), offering a powerful tool for studying liver health and disease. Compatible with automation and high-throughput screening, it’s paving the way for breakthroughs in therapies for liver diseases and cancer. 🔗 Download the poster now to learn more: https://lnkd.in/eanzwqam #LiverOnChip #FibrosisResearch #GeneDelivery #DrugDiscovery

💡 The article was published in Journal of Translational Medicine, called Relationship between vaginal and oral microbiome in patients of human papillomavirus (HPV) infection and cervical cancer. 🌈 The aim of this study was to assess the microbial variations and biomarkers in the vaginal and oral environments of patients with human papillomavirus (HPV) and cervical cancer (CC) and to develop novel prediction models. 🔍 Microbiota analysis was conducted using full-length 16S rDNA gene sequencing with the PacBio platform. HPV infection and CC impact both the vaginal and oral microenvironments, affecting systemic metabolism and the synergy between bacteria. This suggests that the use of oral flora markers is a potential screening tool for the diagnosis of CC. 🔬 BMKGENE provided sequencing and analysis services of full-length 16S rDNA gene for this study. #FullLength16S #Microbiome #HumanPapillomavirus #CervicalCancer #BMKGENE

💡 The article was published in Journal of Translational Medicine, called Relationship between vaginal and oral microbiome in patients of human papillomavirus (HPV) infection and cervical cancer. 🌈 The aim of this study was to assess the microbial variations and biomarkers in the vaginal and oral environments of patients with human papillomavirus (HPV) and cervical cancer (CC) and to develop novel prediction models. 🔍 Microbiota analysis was conducted using full-length 16S rDNA gene sequencing with the PacBio platform. HPV infection and CC impact both the vaginal and oral microenvironments, affecting systemic metabolism and the synergy between bacteria. This suggests that the use of oral flora markers is a potential screening tool for the diagnosis of CC. 🔬 BMKGENE provided sequencing and analysis services of full-length 16S rDNA gene for this study. #FullLength16S #Microbiome #HumanPapillomavirus #CervicalCancer #BMKGENE

https://lnkd.in/e9Tn3ZMs Article title: Lenalidomide as potential treatment in small cell neuroendocrine lung cancer with del 5q Author(s): Paul Hartel Journal: Scientific Journal of Genetics and Gene Therapy Journal ISSN: 2640-7744 Abstract: Lung cancer is a leading cause of cancer deaths world-wide, with the carcinogens in tobacco smoke playing a major etiologic role. Genetic changes responsible for carcinogenesis include activation of proto-oncogenes and inactivation of tumor suppressor genes. Tumor suppressor gene inactivation is contributed to, in part, by loss of chromosomal DNA. While cytogenetic findings in small cell neuroendocrine lung carcinoma are complex, 5q deletion is among the most frequently identified.   #ClassicalAndDevelopmentalGenetics #ConservationAndEcologicalGenetics #EvolutionaryAndPopulationGenetics #GeneticEngineering #GeneticsOfPlantsAndAnimalsInAgronomy #Genomics #Peertechz #PeertechzPublications #HumanAndMedicalGenetics #QuantitativeGenetics #PopulationGenetics #PsychiatricGenetics #MicrobialGenetics #MolecularGenetics #GeneCharacterization #Polymorphisms #ControlOfGeneExpression #Epigenetics #TechnicalTipsAndImprovement #EpigeneticsAndChromosomeBiology #FunctionalGenetics #HumanPopulationGenetics #PlantPopulationGenetics #AnimalPopulationGenetics #ComplexTraits #QuantitativeGenetics #StatisticalAndComputationalGenetics #SomaticGeneTherapy #VectorsInGeneTherapy #Viruses #GermlineGeneTherapy #MajorDevelopmentsInGeneTherapy #NonViralMethods #PreventiveGeneTherapy

Exploring new frontiers in cancer treatment, gene therapy offers promising strategies to combat this pervasive disease. From boosting the body's immune response to directly targeting cancer cells with oncolytic viruses and delivering therapeutic genes, these advanced techniques represent a significant shift towards more personalized and effective treatments. At InfinixBio, we're proud to contribute to this innovative field, supporting research that aims to refine these methods and bring them closer to clinical application. Join us in discussing how gene therapy is reshaping the battle against cancer. #CancerResearch #GeneTherapy #InnovativeTreatment #InfinixBio #Oncology

#PreCancer Models: The UC San Diego HUMANOID: Human Organoid Center of Research Excellence (CoRE) proudly presents (link👇) its inaugural work on #organoid models that enable us to #precisely estimate the #risk of #cancers in those who are #genetically #predisposed. Serving as dynamic expandable platforms that harbor major #hereditary #colorectal cancer (#CRC) syndromes, they offer the limitless #potential to ask/answer how our #environment (#toxins, #diet, #microbes) modifies cancer #risk. In this work, our living biobank of computationally-vetted patient derived organoids (#PDOs) reveal the relative contribution(s) of host #genetics and the #CRC-associated #microbes as co-conspirators in cancers. Our research reveals that both play significant roles in cancer risk: while #genetics may very well set the baseline susceptibility, gene expression changes appear to b driven by microbial interactions that dynamically influence the progression towards cancer. In doing so, this work opens new avenues for #chemoprevention and #treatment strategies in those with genetic predisposition as well as those resulting from chronic inflammation in the setting of dysbiosis (#IBD and others). Link to article on BioRxiv (a PrePrint Server): https://lnkd.in/gSB8g9-5 Congratulations to co-authors: Ibrahim M Sayed, Daniella Vo, Joshua Alcantara, Kaili Inouye, Rama Pranadinata, @Linda Luo, Rick Boland, @Nidhi P Goyal, Dennis Kuo, Sherry C. Huang, MD, Debashis Sahoo, Pradipta Ghosh, Soumita Das. #microbes; #cancer; #cancergnetics, #polyps; ATCC; Molecular Devices; Danaher Corporation; Cellesce Ltd, MilliporeSigma

The study explores the use of intratumoral non-viral gene-immune therapy with OX40 ligand to enhance antitumoral immunity in various cancer models. Results show that the OX40L/PPT nanoparticles successfully inhibited tumor growth, increased antitumoral immune cells, and demonstrated good treatment tolerability without adverse effects. Combining OX40L gene therapy with PD-1 immune checkpoint blockade further enhanced treatment efficacy, emphasizing its potential in advancing cancer therapy. #geneimmunotherapy #cancerresearch #antitumoralimmunity #biohacking #immunotherapytips Read more here: https://lnkd.in/eNkBv7YK BioMedHack.com is your leading source for the latest news, breakthroughs, and insights in medicine, biohacking, and alternative medicine. Our mission is to help you live healthier and longer by bringing you cutting-edge information and expert advice. Follow us on Facebook, Instagram, and X.