Clene Nanomedicine, Inc.’s Post

Excited to share our latest work with collaborators in the University of Düsseldorf. We developed novel HDAC inhibitors with superior anti-leukemia activity, synergy with chemo (decitabine/clofarabine) & excellent pharmacokinetics and in vivo efficacy. Universitätsklinikum Düsseldorf https://lnkd.in/edPrnSTF

It’s great to be here at the North American ISSX and JSSX Meeting in lovely Hawaii! We’re looking forward to seeing some new and familiar faces as we immerse ourselves in the very latest in translational xenobiotic research. Connect with us at booth #112, where our experts will be on hand to discuss how we can help unlock greater translational insights from your preclinical studies. And, don’t forget to check out some of our latest research, summarized in poster #P217 “Liver Humanized Chimeric PXB-Mouse as a Model to Predict Human Renal Toxicity by Aldehyde Oxidase Dependent Metabolism of SGX523” #ISSX #JSSX #Xenobiotics #Metabolism #Pharmacokinetics #ADME #DMPK #DrugDiscovery #HumanizedMice

Introducing HYBRID-ON: A Breakthrough in Oligonucleotide Detection! At ADViRNA, we’re proud to unveil HYBRID-ON, our innovative ELISA-based assay designed to tackle the challenges of detecting therapeutic oligonucleotides. Our HYBRID-ON assay changes the game with: ✅ Sequence-agnostic detection for various oligonucleotides. ✅ High sensitivity (1-1000 fmol), perfect for small sample sizes. ✅ Adaptability to multiple sample types like cultured cells, plasma, and tissues. ✅ Optimized for chemically modified oligonucleotides. Whether you’re investigating siRNA, ASOs, or other therapeutic oligonucleotides, HYBRID-ON simplifies and enhances the detection process. Want to learn more about how HYBRID-ON can improve your research? Contact us today! https://lnkd.in/erNW4Aer #RNAi #OligonucleotideResearch #siRNA #ELISA #ADViRNA #Biodistribution #HybridOn #Therapeutics #Innovation

Please check our latest review article, "Advances in the Structural Basis for Angiotensin-1 Converting Enzyme (ACE) Inhibitors", published in Bioscience Reports!

NRFHH happy to share the review entitled “ATP-Citrate Lyase (ACLY): An Extensive Investigation from Molecular Insight to Therapeutic implications”. This review provides a detailed account of the roles played by ACLY, exploring its molecular process, structure, regulatory pathways, and its impact on physiological and pathological conditions. It delves into ACLY inhibitors, elucidating their molecular mechanisms in clinical studies. The review concludes with an analysis of challenges in developing and optimizing ACLY inhibitors, suggesting strategies to overcome these hurdles. It also presents insights on potential routes for future ACLY inhibitor development, paving the way for advancements in therapeutic implications. Read full text at https://lnkd.in/gihyCrgR

#ACROHighlights [Featured Product] 🚀 Harnessing Cardiac Organoids for Enhanced Drug Development 🌟 Drug-induced cardiotoxicity is a significant challenge in new drug development. Due to their physiological relevance and reproducibility, cardiac organoids derived from iPSCs are now a game-changer for high-throughput drug safety screening. At ACROBiosystems, we've developed cardiac organoids that accurately predict drug-induced cardiotoxicity. But we don't stop there! Our ongoing research also covers other organoid models, including brain, liver, and intestines, to offer comprehensive support for future clinical trials. Join us at the forefront of innovation in drug development! 💊✨ 🔗https://lnkd.in/gzPuS_xg #Biotech #DrugDevelopment #Organoids #iPSCs #AllianzBioinnovation #Research #India #ACROBiosystems

Exciting Research Update! We're thrilled to share a recent publication that utilized our Calprotectin ELISA Assay Kit to explore the predictive power of patient-derived materials for clinical responsiveness to tofacitinib, a Janus kinase (JAK) inhibitor, in treating ulcerative colitis (UC). Key Takeaways: 🔹Patient-derived intestinal organoids were used to predict individual clinical responsiveness to tofacitinib prior to treatment. 🔹Sensitivity of organoids to tofacitinib correlated with drug responsiveness in patients, linked to the inhibition of STAT1 phosphorylation and cell viability upon cytokine stimulation. 🔹Decreased levels of the cationic transporter MATE1, responsible for tofacitinib uptake, were associated with reduced drug responsiveness. 🔹The study provides a potential method for predicting patient response to tofacitinib, which could lead to more personalized and effective treatment strategies for UC. #research #calprotectin #eaglebio https://buff.ly/4bphq1A

𝗠𝗶𝘀𝘀𝗲𝗱 𝘁𝗵𝗲 𝗡𝗮𝗻𝗶𝗼𝗻 𝗨𝘀𝗲𝗿 𝗠𝗲𝗲𝘁𝗶𝗻𝗴? We've got you covered! You can now access the on-demand recordings and watch them at your own pace, anytime, anywhere. Explore these insightful topics: ▪️High throughput phenotyping of cardiac ion channel variants ▪️KV3 channel positive allosteric modulators as a precision medicine approach for the treatment of progressive myoclonic epilepsy ▪️Cell-free systems for the production and functional characterization of membrane proteins ▪️Real-Time Peptide Differentiation: Insights from Nanopore Technology ▪️Pore forming toxins: from molecular mechanisms to nanosensing ▪️Structure-based analysis of proteolytic and ligand-mediated ENaC activation ▪️High throughput phenotyping of cardiac ion channel variants ▪️Profiling GPCR pharmacology using impedance monitoring of cell-based assays ▪️PI-(3,5)P2 mediated oligomerization of the endosomal Na+/H+ exchanger NHE9 Catch up on insightful talks, and stay inspired. 💡 Watch now: https://ow.ly/IgMT50UaOy8 #NanionUserMeeting #ScientificMeeting #APC #CellAnalytics #MembraneBiophysics

Ready to elevate your drug discovery research with state-of-the-art functional assays for 5-Hydroxytryptamine Receptors? ICE Bioscience is your gateway to innovation.   ✅ HTRF cAMP Assay: used to measure the intracellular levels of cyclic adenosine monophosphate (cAMP), a second messenger molecule generated upon GPCR activation. ✅ HTRF IP1 Assay: used to measure the production of inositol monophosphate (IP1), which is generated downstream of G protein-coupled receptor (GPCR) activation. ✅ Calcium Flux Assay by FLIPR: used in pharmacological research to measure changes in intracellular calcium levels in response to cellular stimulation. ✅ β-arrestin NanoBiT assay: used to assess the recruitment of β-arrestin to GPCR upon ligand activation. 5-Hydroxytryptamine receptors are widely distributed throughout the central nervous system (CNS) and peripheral tissues, playing important roles in various physiological processes, including mood regulation, cognition, appetite, sleep, gastrointestinal function, cardiovascular function, and perception of pain.   Understanding the function and pharmacology of serotonin receptors is important for the development of drugs targeting these receptors for the treatment of various neurological and psychiatric disorders. #GPCR #5Hydroxytryptamine #HTRF #serotonin #receptors #cAMP #IP1 #calciumfiux #βarrestin

𝐍𝐄𝐖 𝐀𝐑𝐓𝐈𝐂𝐋𝐄 𝗦𝘆𝗻𝘁𝗵𝗲𝘀𝗶𝘀, 𝘀𝗽𝗲𝗰𝘁𝗿𝗼𝘀𝗰𝗼𝗽𝗶𝗰 𝗰𝗵𝗮𝗿𝗮𝗰𝘁𝗲𝗿𝗶𝘇𝗮𝘁𝗶𝗼𝗻, 𝗗𝗙𝗧 𝗮𝗻𝗱 𝗺𝗼𝗹𝗲𝗰𝘂𝗹𝗮𝗿 𝗱𝗼𝗰𝗸𝗶𝗻𝗴 𝗼𝗳 𝗡-(𝟯-𝗰𝘆𝗮𝗻𝗼-𝟰,𝟱,𝟲,𝟳-𝘁𝗲𝘁𝗿𝗮𝗵𝘆𝗱𝗿𝗼𝗯𝗲𝗻𝘇𝗼[𝗯]𝘁𝗵𝗶𝗼𝗽𝗵𝗲𝗻-𝟮-𝘆𝗹) 𝗻𝗮𝗽𝗵𝘁𝗵𝗮𝗹𝗲𝗻𝗲-𝟭-𝘀𝘂𝗹𝗳𝗼𝗻𝗮𝗺𝗶𝗱𝗲 𝗱𝗲𝗿𝗶𝘃𝗮𝘁𝗶𝘃𝗲𝘀 𝐀𝐁𝐒𝐓𝐑𝐀𝐂𝐓 Liver pyruvate kinase (PKL) is a key player in controlling metabolic pathways and ATP production within the liver’s glycolysis pathway. Since PKL modulators have been identified as a promising target for treating hepatocellular carcinoma (HCC) and non-alcoholic fatty liver disease (NAFLD), our research is centered on the development and synthesis of derivatives of N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl) naphthalene- 1-sulfonamide with the aim of modulating PLK. To improve PKL specificity, we used structural analysis and modeling as a guide. Notably, compound PKL-05 became the series’ only active ingredient. DFT, Hirshfeld surface analysis, and molecular docking were used in our study to thoroughly examine the connection between compound structures and their computational functions. The global hardness and softness energy values, as well as the HOMO-LUMO energy gap value, were computed in order to forecast the chemical reactivity of this newly synthesized molecule. These energy values indicate that this molecule tends to be chemically stable and has little chemical reactivity. The results demonstrated a strong agreement between theoretical forecasts and experimental findings. In particular, PKL-05 exhibits encouraging traits that establish it as a useful starting point for additional research in the search for innovative PKL modulators to tackle the treatment issues associated with NAFLD and HCC. 𝐋𝐞𝐚𝐫𝐧 𝐦𝐨𝐫𝐞 𝐚𝐛𝐨𝐮𝐭 𝐨𝐮𝐫 𝐚𝐩𝐩𝐫𝐨𝐚𝐜𝐡 𝐚𝐧𝐝 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐢𝐞𝐬 𝐢𝐧 𝐭𝐡𝐞 𝐟𝐮𝐥𝐥 𝐚𝐫𝐭𝐢𝐜𝐥𝐞. https://lnkd.in/d_Hvn-Ey #drugdiscovery #medchem #LiverDisease #NAFLD #MolecularModeling #ResearchInnovation Trustlife Labs Drug R&D Center Trustlife Ventures