Center for Neuroscience and Cell Biology’s Post

AlzeCure presents new preclinical data with NeuroRestore ACD856 at leading Alzheimer's conference Exciting news from AlzeCure as new preclinical data for NeuroRestore ACD856 is presented at a top Alzheimer's conference promising breakthroughs in treatment. #AlzheimersResearch #AlzeCure #NeuroRestore #ACD856 #DrugDevelopment #NeuroScience #pharmiwebcom

Inducing Neuronal Differentiation in SH-SY5Y Cells with Retinoic Acid Our research is focused on investigating the efficacy of retinoic acid in inducing neuronal differentiation within SH-SY5Y cell lines. By carefully manipulating experimental conditions, we aim to optimize the differentiation process and characterize the resulting neuronal phenotypes. These findings will contribute to our understanding of neuronal development and provide a valuable in vitro model for studying neurodegenerative diseases. #neuroscience #cellbiology #SHSY5Y #differentiation #retinoicacid #invitromodel #research

🧬🔬 Unraveling the Formation of the Spinal Cord: The Role of Protein Families in Embryonic Development 🔬🧬 Groundbreaking research has shed light on how a family of proteins plays a crucial role in the formation of the spinal cord during embryonic development. This discovery enhances our understanding of neural development and could pave the way for future medical advancements. 🧑🔬👶 Learn more about this fascinating study: https://lnkd.in/gSFA32Mj . . . . . . .. . . . . . . . .. . . #EmbryonicDevelopment #Neuroscience #ProteinResearch #MedicalScience #MedBoundTimes MedBound Times MedBound

☑️ *READ DESCRIPTION BELOW:* Schematic of the establishment of Patient-derived sarcoma organoids (PDSOs) and their applications. Sarcoma cells obtained from patients are grown into tumor organoids using scaffold-free, scaffold-based, and xenograft-based techniques. These patient-derived organoids realistically replicate the biological, histological, and functional characteristics of the primary tumor. By accurately recapitulating the complexity of the tumor microenvironment, PDSOs provide a promising approach to unravel sarcoma biology, discover novel therapeutic targets, and ultimately enhance patient outcomes https://lnkd.in/et9kTiwN #Gesundheit #Bildung #Fuehrung #Coaching #Mindset #Motivation #Gehirn #Neuroscience #Psychologie #Persoenlichkeitsentwicklung #Kindheit #KeyNoteSpeaker #Humangenetik #Biochemie #Neuroleadership #Ernaehrung #Transformation #Stress #Demografie #Gender #Age #interkulturelleKompetenz #Epigenetik #Veraenderung #EmotionaleIntelligenz #Change #Gesellschaft #Organisationsentwicklung #Philosophie #Beratung # Quantum

Watch our recent webinar on Translational Outcome Measures, now on-demand! Discover key measures in pigs to bridge preclinical and clinical research, and explore what’s next to achieve more translational outcomes. https://hubs.la/Q02XnPsb0 #TranslationalResearch #PainResearch #Neuroscience #PreclinicalResearch #TranslationalMedicine #PreclinicalModels #DrugDevelopment #Webinar #CNSResearch #PainManagement

🌟 Unlocking the Secrets of Brain Regeneration: Lessons from the Axolotl 🧠✨ A 2022 study published in Science takes an in-depth look at the axolotl, an extraordinary creature known for its remarkable brain regeneration capabilities. Unlike mammals, the axolotl can repair its brain following injury by leveraging a diverse set of neurons and stem cells. 🔬 Key findings include: The axolotl telencephalon contains a wide range of cell types, crucial for regeneration. Neurogenesis (the creation of new neurons) allows for both homeostatic maintenance and repair of brain tissue, a process far more advanced than in mammals like mice. The study shows how conserved cell types across species could unlock potential insights into brain repair for humans. Understanding how this process works in axolotls could one day lead to groundbreaking treatments for brain injuries in humans. 🧬 #Neuroscience #Regeneration #BrainResearch #Axolotl #BioByPriti #InnovationInScience

#ACROHighlights [Featured Product] 🌟 Dual Roles of Extracellular Vesicles in Neurodegeneration 🌟 Extracellular vesicles (EVs), including exosomes, are tiny cellular messengers that influence a variety of physiological and pathological processes. Recent research reveals their dual role in neurodegenerative diseases like Alzheimer's (AD), Parkinson's (PD), and ALS. On one hand, EVs can cross the blood-brain barrier, transporting harmful proteins between neurons and potentially speeding up disease progression. On the other hand, EVs derived from mesenchymal stem cells can promote neurogenesis, protect neurons, reduce Aβ deposition, and inhibit BACE1 activity, offering a potential slowing of AD progression. 🔗 Explore Aneuro to Empower Your Research: https://smpl.is/99okr #Neuroscience #Neurodegeneration #Alzheimers #Parkinsons #ALS #ExtracellularVesicles #Research #Biotech #Aneuro #ACROBiosystems

Clinostar’s proprietary clinostat tech supports more physiological in vitro model development.   Scientists at Drexel University in Philadelphia have compared the morphology of forebrain organoids cultured in the ClinoStar and in standard orbital shaker methods.   See some of the results here:   * Absence of Central Necrosis: The ClinoStar promotes the growth of healthy organoids without a central necrotic core. The low shear stress conditions and efficient diffusion of nutrients and oxygen in the ClinoStar prevent the formation of a necrotic core, allowing long-term growth and maintenance of organoids that better mimic the physiological state and functionality of the brain.   * Enhanced Morphology: Dr. Qiang’s team at Drexel University found that dorsally patterned forebrain organoids developed in the ClinoStar had distinct loops or rosettes of neuroepithelial cells after 30 days, which were not present in organoids grown using standard orbital shaker methods. This indicates that the ClinoStar supports more complex and accurate brain-like development.   * Better Cellular Symmetry and Health: After 45 days of culture in the ClinoStar, the organoids showed no signs of necrotic core formation and maintained a healthy population of neuronal and non-neuronal support cells throughout the organoid. Additionally, cortical plate-like symmetry with migratory early neurons was observed, which was not seen in organoids grown using orbital shakers. This suggests that the ClinoStar enables more physiologically relevant development. See the results in the document. #ClinoStar #OrbitalShakers #3DCellCulture #Organoids #Neuroscience

𝗡𝗲𝘄 𝗦𝘁𝘂𝗱𝘆 𝗜𝗱𝗲𝗻𝘁𝗶𝗳𝗶𝗲𝘀 𝗞𝗲𝘆 𝗡𝗲𝘂𝗿𝗼𝗻𝘀 𝗶𝗻 𝗛𝘆𝗽𝗼𝘁𝗵𝗮𝗹𝗮𝗺𝘂𝘀 𝗖𝗼𝗻𝘁𝗿𝗼𝗹 𝗔𝗴𝗶𝗻𝗴 🧠 Neuron Role: DMHPpp1r17 neurons in the hypothalamus regulate white adipose tissue (WAT) function and physical activity. #Neuroscience #Aging 🔬 Mechanism: Ageing causes Ppp1r17 to move from the nucleus to the cytoplasm, disrupting synaptic function. #Biochemistry #SynapticFunction 🧬 Therapeutic Potential: Reducing Prkg1 in the DMH counteracts aging effects and extends lifespan in mice. #Therapies #Longevity 🧪 Activity Activation: Chemogenetic activation of DMHPpp1r17 neurons increases physical activity and delays aging. #Genetics #Research 📊 Broader Impact: Findings highlight the significance of hypothalamus-WAT communication in aging and longevity. #HealthSpan #Research Check it out: https://lnkd.in/et8q6tdU

I'm happy to share that another paper has been published in the special issue "Neurodegenerative Diseases: Recent Advances and Future Perspectives": 📝 OCT Imaging in Murine Models of Alzheimer’s Disease in a Systematic Review: Findings, Methodology and Future Perspectives - Sánchez-Puebla et al. This study aimed to review the diverse optical coherence tomography (OCT) analysis methods that have been carried out in murine models of Alzheimer’s disease and to analyse what type of OCT has been used, which retinal sectors have been analysed, as well as the retinal layer segmentation and which software has been used for that. 👉 Full text is available at https://lnkd.in/dt7CybjN #neuroscience Biomedicines MDPI