Combat Medical Ltd’s Post

Yesterday’s post about the new study published this week in Gut*, which has found a strong correlation between the typical Western diet – high in ultra-processed foods (UPF) and inflammatory seed oils – and colorectal cancer risk. “Our bodies are designed to actively resolve inflammation through bioactive lipid compounds derived from the healthy fats, like avocados, that we consume,” said Ganesh Halade, associate professor at the University of South Florida Heart Institute and a member of the Cancer Biology Program at Tampa General Hospital (TGH) Cancer Institute. “Bioactive lipids are very small molecules derived from the foods that we eat. If the molecules are coming from processed food products, they directly imbalance the immune system and drive chronic inflammation.” Halade’s team used a highly sensitive analytical technique to identify trace amounts of lipids in 162 tumour samples from patients at TGH. They discovered an excess number of molecules that promote inflammation and a shortage of those that help resolve it and promote healing. “The immune system can be extremely powerful and drastically impact the tumour microenvironment, which is great if harnessed correctly for health and wellness – but not if it’s suppressed by inflammatory lipids from processed foods,” said Dr Timothy Yeatman, professor of surgery in the USF Health Morsani College of Medicine and associate centre director for Translational Research and Innovation at the TGH Cancer Institute. *Soundararajan R et al. Integration of lipidomics with targeted, single cell, and spatial transcriptomics defines an unresolved pro-inflammatory state in colon cancer. Gut Published Online First: 10 December 2024. doi: 10.1136/gutjnl-2024-332535 #medicalinnovation #Decembeard #bowelcancer #coloncancer #HIPEC #CombatMedical