Danaher Life Sciences’ Post

Glycan analysis is key to improving protein therapeutics, from enhancing efficacy to ensuring batch consistency. In this on-demand webinar, Mike McKinnon, Scientist II at Novartis, explores how achieving high-resolution glycan information can ensure the stability, safety and efficacy of your product. You will learn about: 🔎New strategies for glycan site localization on a tri-specific antibody 🔎Benefits of electron activated dissociation (EAD) for glycan profile determination 🔎Streamline glycan characterization throughout the drug development pipeline with novel methods Don't miss out—watch now and discover how glycan analysis can take your research to the next level 👉 https://sciex.li/bicmid #GlycanAnalysis #Biopharma #TriSpecificAntibody #Biologics #LifeSciences #Webinar #Innovation #PharmaceuticalResearch

From ADCs to XDCs, the boundaries of bioconjugates are continually expanding. The journey to develop bioconjugates is fraught with complexity and challenges, that's why we've dedicated ourselves to groundbreaking innovations. At WuXi XDC, we have conducted a vast array of projects across bioconjugation landscape. Our capability from ADCs to XDCs: ⭐ADC/BsADC ⭐Antibody-Oligonucleotide Conjugate ⭐Antibody-Chelator Conjugate ⭐Degrader Antibody Conjugate ⭐Immuno-Stimulant Antibody Conjugate ⭐Antibody-Peptide Conjugate ⭐Vaccine Conjugate ⭐PEGylation-Based Conjugate ⭐Protein-Protein Conjugate ⭐Antibody-Glycan Conjugate ⭐Antibody-Fluorophore Conjugate ⭐Peptide-Oligo Conjugate and more... Through our integrated platform, we have empowered nearly 345 global partners, delivered over 10,000 bioconjugates, and supported more than 570 ADC & XDC Discovery and CMC projects (as of December 31, 2023). Embark on a journey with WuXi XDC, where innovation yields significant impact. Together, let's transform the bioconjugates landscape. https://lnkd.in/gvqifhdr #adcdiscovery #bioconjugation #antibodydisocvery #biomanufacturing #biopharma #biologics #biotherapeutics #ADC #antibodydrugconjugate

An interesting article which discusses the effects trace metals can have on cell culture performance. #tracemetals #cellculturemedia #mammaliancellculture #bioprocessing #biotherapeutics #biopharmaceuticals https://lnkd.in/eduEpdCt

Nice to see that our second paper on reversible protein complexes has been published! The focus was to test this innovative protein formulation concept for its potential in the subcutaneous delivery of high-concentration biologics using an in vitro tool. Congratulations to the main contributors and ex-colleagues Vanessa Braun, Vanessa Lebouc-Häfliger and Pierre-Louis Destruel. #Drug_Delivery #Biologics #Subcutaneous #HighConcentration_biologics #invitro_sc_model

Developing biologic therapeutics, like antibodies, require a robust analytical strategy that can provide you with rapid and accurate data to drive informed decision making at each stage of development. Without reliable data, critical milestones can get delayed and overall program risk increases.   Abzena’s LabZient™ analytical platform helps overcome these challenges by efficiently generating the high-quality data needed to better understand a molecule’s characteristics and behavior. By employing advanced predictive in-silico evaluations and standardized methods, LabZient™ greatly reduces the uncertainty associated with analytical methods and streamlines the process from molecule assessment to validation at an accelerated pace.    This innovative approach not only expedites the path to IND but also enhances the overall efficiency and accuracy of the analytical process. Discover how LabZient™ can advance your biologic towards clinical success faster: https://lnkd.in/ebVjPU6u   #DrugDevelopment #Biologics #Analytics #CDMO #LabZient™ #CRO

𝐍𝐞𝐰 𝐰𝐞𝐛𝐢𝐧𝐚𝐫 𝐨𝐧 𝐦𝐚𝐬𝐭𝐞𝐫𝐢𝐧𝐠 𝐜𝐞𝐥𝐥 𝐜𝐮𝐥𝐭𝐮𝐫𝐞 𝐬𝐜𝐚𝐥𝐞-𝐮𝐩!  Hear from Tyler Younger, as he discusses the impact of sparging gases and its effects on cell viability. From bubble formation to bursting, we share valuable insights on managing gas entrance velocity, especially for CHO and shear-sensitive cell lines, like NS0. Curious about our breakthrough? Watch the full webinar now to discover how we've optimized conditions beyond standard limits without compromising cell growth! #biotech #pharmaceuticals #LifeScience #Biotechnology #biologics #advancedtherapies #Biopharmaceuticals #biopharma #pharma #AGCBio #CDMO 

📢Boosting Monoclonal Antibody Efficiency with Maduramycin: A Game-Changing Modulator! 🔍 A recent study has discovered a new modulator, maduramycin, that enhances M5 glycans in monoclonal antibodies mAbs. 🧪 Maduramycin is especially beneficial for subcutaneously-administered biologics and offers an alternative to existing modulators. 👩🔬 Scientists found that maduramycin increased M5 glycans for mAbs in both fed-batch and steady-state perfusion processes. 🔬 The combination of maduramycin and kifunensine allows manufacturers to control high-mannose distribution in manufacturing processes. #BioprocessUpdates #monoclonalantibodies #glycosylation #maduramycin #M5modulator #biologics #subcutaneousadministration #fedbatchprocess #steadystateperfusion #kifunensine #highmannosedistribution #scientificresearch #pharmaceuticalindustry #biotechnology #glycanmodification #manufacturingprocesses ▷ Read the full article here: 📎 https://lnkd.in/dn6tT4PS

🌱🔬 Microbiology plays a critical role in pharmaceuticals, transforming the way we approach drug development and patient care. From combating antibiotic resistance to ensuring safety and efficacy in vaccines, microbiologists are at the forefront of innovation. 💊✨But here's the question: How can we harness the power of microorganisms to pave the way for next-gen therapeutics? 💡Let’s dive into discussions about breakthroughs in microbiome research, biopharmaceuticals, and the future of precision medicine. #Microbiology #Pharmaceuticals #Innovation #Healthcare #Biotech

Co-elution of host cell proteins (HCPs) can complicate purification, often leading to costly, time-consuming downstream solutions. But what if there’s a smarter way? In this case study, discover how AGC Biologics used CRISPR-based cell line engineering to tackle a complex HCP challenge - saving time, reducing costs, and boosting product titer by nearly 40%. Find the link in the comments below to download the full study. #biotech #pharmaceuticals #LifeScience #Biotechnology #biologics #Biopharmaceuticals #biopharma #pharma #AGCBio #CDMO #YourfriendlyCDMOexpert