Dave Gentry’s Post

Enlivex (Nasdaq: $ENLV), a leader in macrophage reprogramming immunotherapy, has launched a brand new website! Discover their innovative Allocetra™ therapy, designed to reset macrophages and rebalance the immune system. Visit now to learn more: https://ow.ly/pey450SSmEK #macrophages #immunesystem #osteoarthritis #Biotechnology #biotech #stocks #stockmarket #nasdaq #StockMarketNews

Did you know that the majority of natural proteins contain at least one alpha helix? These structures play critical roles in folding, protein and DNA binding, membrane anchoring, and other essential biological processes.       With our Helicon platform, we’ve leveraged the unique capabilities of alpha helices to create a novel class of therapeutics. These stabilized helical peptides are capable of efficient cell entry and modulation of protein-protein and protein-DNA interactions — opening up a vast realm of possibilities to reach targets inaccessible to other kinds of medicines.      Learn more about Helicons here: https://lnkd.in/eWzFMkt9      #Biotechnology #Helicons #CreatingExtraordinaryMedicines   

🌟 Unlocking the Potential of iPSC Culture with FGF-2 TOP 🌟 💡 Why FGF-2 TOP? This innovative protein maintains high-quality #iPSC cultures, supporting #pluripotency and stemness across various concentrations and media feeding regimes. Recent data from Core Biogenesis and TreeFrog Therapeutics demonstrates its effectiveness: ✔️Flow cytometry data shows high expression of pluripotency markers under both 50 and 100 ng/mL FGF-2 TOP, in daily and every-other-day (EOD) feeding schedules. ✔️Impressively, EOD feeding with FGF-2 TOP achieves equivalent results to daily supplementation with traditional FGF-2, underscoring FGF-2 TOP's superior bioactivity and stability. Explore the full whitepaper for an in-depth look at how FGF-2 TOP can drive consistency in your iPSC cultures. https://hubs.ly/Q02X_6KG0 #StemCellResearch #iPSCCulture #BiotechInnovation #FGF2TOP #RegenerativeMedicine #celltherapy #cellandgenetherapy

Purifying low-expressed proteins (LEPs) has always been a time-intensive and costly process, often requiring toxic reagents, extensive optimization, or multiple rounds of purification. 💡 The Solution: Proteios Technology, Inc. proprietary Car9 affinity tag technology, coupled with the RapidPro™ Spin Kit, delivers: High yield: Up to 2mg of protein in a single run. Exceptional purity: 85% to 95%, without toxic metal ions or reagents. Unmatched speed: Purification completed in under 15 minutes! 📈 Real-World Results: Here’s what we achieved with three notoriously low-expressed proteins: ✅ KRAS (oncoprotein involved in pancreatic cancer): Purified with high yield and quality. ✅ TEV protease (used for affinity tag cleavage): Purified despite its low solubility. ✅ T. thermophilus PFK (challenging due to very low expression): Delivered both purity and yield. Learn More: https://lnkd.in/ggfZtFWS #ProteinPurification #RecombinantProteins #AffinityTagTechnology #ProteinResearch #Biotechnology #LifeSciences #RapidPro #ProteiosTechnology

Antibody Specificity: The Cornerstone of Reliable Research Cross-reactivity can lead to inaccurate results and wasted time. 🔬 OriGene’s UltraMABs are rigorously validated to ensure unparalleled specificity. Our proprietary high-density protein microarray tests each antibody against over 17,000 human antigens. Click here to learn more: https://bit.ly/41JKy1J #antibodies #lablife #OriGene

Today's Paper of the Day is on carbon monoxide poisoning: from microbes to therapeutics https://lnkd.in/ddmA2hyy Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2024

This is a great deal. Great way to generate robust data and test the potential impact of seromics (AAb data) in your research - MoA, target ID, biomarker signatures for patient stratification…

Join us to Celebrate the 30th Anniversary of the Protein Stability Conference Aug. 5-8! Topics covered will include: protein structure, thermodynamic stability, folding, and dynamics; stability of AAV vectors; amyloidosis and protein aggregation; engineering protein therapeutics; protein-excipient interactions; characterization of protein particles and new advances in processing of therapeutic proteins. Come find us next week to learn all about ParticleSentryAI and to discuss what kind of studies you are performing on protein aggregation and subvisible particle analysis! #SentrySciences hashtag #ParticleSentryAI hashtag #ProteinStabilityConference

Peptidic Macrocycles as Suitable Bioactive Scaffold for Targeted Protein Degradation with Jakob Fuhrmann from Genentech. The development of proximity-induced degraders still poses several challenges, including their relatively low cell-permeability, as well as high degree of conformational flexibility due to the presence of flexible linker elements. I will present our strategy to identify conformationally constrained macrocyclic degraders. I will further highlight our characterization cascade comprising ternary complex stabilization, as well as property-based optimizations to obtain in vivo bioactive compounds. https://lnkd.in/dpw8vaiv Save $150 with Discount code SPK150. #drugdiscoverychemistry

🛍️ 20% Off SignalChem Tau Proteins and Mutants! Through the end of 2024, researchers in the US and Canada can save on all SignalChem Biotech Inc. Tau products, including our phosphorylated tau proteins and Tau-441 variants. Why choose SignalChem Tau proteins? ✔️ Native Conformations: Tag-free tau proteins mimic native conformation and biological activity. ✔️ Assay Flexibility: Tag-free tau proteins allow for versatile experimental designs. ✔️ Clinical Relevance: Stronger data for therapeutic evaluations when evaluating potential therapeutic interventions Explore our extensive range of premium recombinant tau proteins: https://ow.ly/RfY850UcR1p