David Provenzano’s Post

Meet Dr. Shilpa Hattangadi, a pediatric hematologist and program director at NIDDK. From overseeing programs in hematopoiesis, which is the production and function of blood cells, to empowering the next generation of researchers, Dr. Hattangadi is making waves in the field of biomedical research. "The beauty of research is that it never ends. The right kinds of studies uncover more questions. The best studies create immediate questions for the next ten years as well as the foundation for entire future whole fields." Read more about her professional journey in the latest Director's Update. https://lnkd.in/duQRMMXw #DKupdate

📣We share the #Article "Influence of Mechanical Alignment on Functional Knee Phenotypes and Clinical Outcomes in Primary TKA: A 1-Year Prospective Analysis" 🧐by Dominik Rak, Lukas Klann, et al. 🗺 Orthopädische Klinik König-Ludwig-Haus 🎯 Access the full paper here👉 https://lnkd.in/gnvJbUfG #kneearthroplasty #mechanicalalignment #clinicaloutcome #phenotype #levelofevidenceIII #prospectivestudy Journal of Personalized Medicine MDPI

🚀 Fresh off the press! 📰 Thrilled to share our latest publication: "A novel approach to refractory coccydynia: ultrasound-fluoroscopy-guided cryoablation of sacrococcygeal nerve." published in Pain Management Journal. Coccydynia is a complex clinical challenge due to its diverse etiologies and the limited treatment options for refractory cases. In this study, we introduce a novel cryoablation technique tailored to treat posterior coccydynia. This innovative approach, guided by both ultrasound and fluoroscopy, has shown promising results, as highlighted by the clinical outcomes of two patients who underwent the procedure. A special shoutout to Inês Mendes Andrade for her incredible work and first authorship on this paper! 👏 Looking forward to seeing the impact of this new technique on the management of chronic coccydynia and helping patients find relief. https://lnkd.in/dKvB5X-x Robert Pagán-Rosado, MD Mark Hurdle #Coccydynia #Cryoablation #PainManagement #UltrasoundGuided #Fluoroscopy #InterventionalPain #Research

Electrocardiogram digitized for the first time in 120 years! [1] The measurement of ECG data has become very simple, very precise, in milliseconds (ms). [2] In addition, invasive parameters can be determined. [3] Including invasive, undetectable parameters. PhysioSign solves existing ECG problems: (a) Data automation, mapping in milliseconds (ms). (b) Morphological changes, automatic indications. - Scientific article published in the International Journal of Cardiology in 2016 - 15 million clinical trials completed in 6 countries in 2015 - 53 US & International patents obtained PhysioSign USA

🔬 Accel-Heal Clinical Update: New Paper Published in ‘Advances in Wound Care’ Journal 🔬 Exciting news! The esteemed A*STAR Skin Research Labs (ASRL) in Singapore has recently published groundbreaking research in the 'Advances in Wound Care' journal. This paper delves into the mechanisms of micro-current Electroceutical Stimulation Therapy (EST) devices, with a special focus on Accel-Heal's efficacy in chronic wound healing. Over 37 randomized controlled clinical trials have demonstrated that EST can stimulate wound healing of chronic wounds. ASRL's research further enriches our understanding of how micro-current EST devices like Accel-Heal produce this effect. In addition, the findings unveil a compelling adjunctive benefit of Accel-Heal - potential enhancement in the quality of healed skin. Access the open-access paper titled "Automated Electrical Stimulation Therapy Accelerates Re-Epithelialization in a Three-Dimensional In Vitro Human Skin Wound Model" via the link below: 📌 https://lnkd.in/gqDEwymX #AdvancedWoundCare #ClinicalResearch #AccelHeal #ASRL #EST #Healthcare #IntellimedHealthcare

A Stanford Medicine study found that metformin, a commonly prescribed diabetes drug associated with moderate weight loss, stimulates the production of lac-phe, a molecule abundant after exercise. A new study in mice and humans has found that an "anti-hunger" molecule produced after vigorous exercise is responsible for the moderate weight loss caused by the diabetes medication metformin. The molecule, lac-phe, was discovered by Stanford Medicine researchers in 2022. "Now we know that [the molecule] is acting through the same pathway as vigorous exercise to reduce hunger," states Jonathan Long, Ph. D., assistant professor of pathology at Stanford Medicine. The finding, made jointly by Stanford Medicine and Harvard Medical School researchers, further cements the critical role the molecule lac-phe plays in metabolism, exercise, and appetite. It may pave the way for a new class of weight loss drugs. #Metformin #WeightLoss #StanfordMedicine https://buff.ly/3vwVGRC

Check out this impactful #ClinicalStudy that delves into the comparative diagnostic performance of four major #HCC guidelines, enhanced by cutting-edge MRI techniques and a novel automatic algorithm. Conducted across 11 South Korean hospitals, this retrospective study encompasses 2,237 high-risk patients and evaluates 2,445 focal liver lesions with a focus on accuracy, sensitivity, and specificity. Using #MintLesion, researchers concluded that among 4 different international HCC diagnosis guidelines, Eastern guidelines demonstrate higher sensitivity, whereas Western guidelines displayed higher specificity. The article suggests that respective guidelines are aligned with their corresponding clinical practice and intended outcomes. "Eastern guidelines prioritize sensitivity because of the high prevalence of HCC in Asia and preference for all locoregional therapy, leading to high accuracy (13). Conversely, Western guidelines emphasize specificity, reflecting the lower HCC prevalence in Europe and North America (13) and transplant as a first-line treatment option (4,14)." Read more on the topic here: https://bit.ly/4eFNfp5 Get updates on expert insights and the latest studies using #mintLesion™ to transform medical research by following #ResearchWithMint.

Call for papers: https://lnkd.in/dRznjsMJ This special issue is open to studies on transcatheter interventions on any of the heart’s valves that provide new insight into this field. Papers focused on clinical outcomes, new interventional approaches, and systematic reviews with or without meta-analysis are strongly encouraged. Deadline of manuscript submission: 20 January 2025 #medicina #mdpi #cardiac #transcatheter #heartvalve #specialissue #aorticvalve #mitralvalve #tricuspidvalve #pulmonaryvalve

Estimands in Clinical Research. Very important as a good practice and as a standardization procedure, helping Researchers understand the results better. Estimands are not just about defining ICEs, Treatments, Population, Variables and PL Summary, they are about relating these, connecting the dots between them and seeing how they affect the results. Estimands are used mostly in Clinical Trials today, but many other Research areas, connecting many aspects of research systematically to make interpretation of the results comparable from multiple angles and perspectives is in my opinion a good practice too... If you are interested in an example i wrote on how to define Estimands in Cardiology, link in the comments.

Want to find out what the recent science tells us about Tethered Oral Tissues? I am doing a major literature review (I will make it interesting!) for Praeclarus Press May 31, 2024. What I found out will surprise you and may even dramatically change your clinical practice! Here's the link: chttps://lnkd.in/espR42Kp