🔬 𝐔𝐧𝐥𝐨𝐜𝐤𝐢𝐧𝐠 𝐭𝐡𝐞 𝐌𝐲𝐬𝐭𝐞𝐫𝐢𝐞𝐬 𝐨𝐟 𝐃𝐢𝐚𝐛𝐞𝐭𝐞𝐬: 𝐈𝐧𝐬𝐢𝐠𝐡𝐭𝐬 𝐟𝐫𝐨𝐦 𝐆𝐫𝐞𝐞𝐧𝐥𝐚𝐧𝐝𝐢𝐜 𝐈𝐧𝐮𝐢𝐭 𝐏𝐨𝐩𝐮𝐥𝐚𝐭𝐢𝐨𝐧𝐬 🏃♂️🧬How do 𝐠𝐞𝐧𝐞𝐭𝐢𝐜 𝐦𝐮𝐭𝐚𝐭𝐢𝐨𝐧𝐬 and 𝐥𝐢𝐟𝐞𝐬𝐭𝐲𝐥𝐞 𝐜𝐡𝐨𝐢𝐜𝐞𝐬 intertwine to shape our health? Associate Professor Rasmus Kjøbsted’s research on the TBC1D4 protein offers an answer – 𝐚𝐧𝐝 𝐚 𝐩𝐚𝐭𝐡 𝐟𝐨𝐫𝐰𝐚𝐫𝐝 𝐢𝐧 𝐦𝐚𝐧𝐚𝐠𝐢𝐧𝐠 𝐭𝐲𝐩𝐞 2 𝐝𝐢𝐚𝐛𝐞𝐭𝐞𝐬. Through studies spanning mice and humans, Rasmus Kjøbsted discovered how exercise enhances muscle glucose uptake, even in populations carrying a genetic mutation that increases diabetes risk. 🐁 👨👩👧👦 Speaking about his research, Kjøbsted shares: “𝘞𝘦 𝘥𝘪𝘴𝘤𝘰𝘷𝘦𝘳𝘦𝘥 𝘵𝘩𝘢𝘵 𝘢 𝘴𝘪𝘯𝘨𝘭𝘦 𝘣𝘰𝘶𝘵 𝘰𝘧 𝘦𝘹𝘦𝘳𝘤𝘪𝘴𝘦 𝘦𝘯𝘩𝘢𝘯𝘤𝘦𝘴 𝘪𝘯𝘴𝘶𝘭𝘪𝘯'𝘴 𝘢𝘣𝘪𝘭𝘪𝘵𝘺 𝘵𝘰 𝘩𝘦𝘭𝘱 𝘮𝘶𝘴𝘤𝘭𝘦𝘴 𝘵𝘢𝘬𝘦 𝘶𝘱 𝘨𝘭𝘶𝘤𝘰𝘴𝘦 𝘷𝘪𝘢 𝘛𝘉𝘊1𝘋4, 𝘢 𝘬𝘦𝘺 𝘧𝘢𝘤𝘵𝘰𝘳 𝘪𝘯 𝘤𝘰𝘯𝘵𝘳𝘰𝘭𝘭𝘪𝘯𝘨 𝘣𝘭𝘰𝘰𝘥 𝘴𝘶𝘨𝘢𝘳 𝘭𝘦𝘷𝘦𝘭𝘴.” His work, recently published in 𝘕𝘢𝘵𝘶𝘳𝘦 𝘔𝘦𝘵𝘢𝘣𝘰𝘭𝘪𝘴𝘮, dives deep into the challenges faced by a unique subgroup of Greenlandic Inuit who lack TBC1D4. With advanced techniques and teamwork across Denmark and Greenland, the findings highlight the power of physical activity in managing blood sugar levels. As Kjøbsted explains: “𝘖𝘶𝘳 𝘳𝘦𝘴𝘦𝘢𝘳𝘤𝘩 𝘩𝘪𝘨𝘩𝘭𝘪𝘨𝘩𝘵𝘴 𝘵𝘩𝘦 𝘱𝘰𝘵𝘦𝘯𝘵𝘪𝘢𝘭 𝘰𝘧 𝘭𝘪𝘧𝘦𝘴𝘵𝘺𝘭𝘦 𝘨𝘶𝘪𝘥𝘢𝘯𝘤𝘦 𝘰𝘷𝘦𝘳 𝘮𝘦𝘥𝘪𝘤𝘢𝘵𝘪𝘰𝘯 𝘧𝘰𝘳 𝘵𝘩𝘦 𝘱𝘳𝘦𝘷𝘦𝘯𝘵𝘪𝘰𝘯 𝘢𝘯𝘥 𝘵𝘳𝘦𝘢𝘵𝘮𝘦𝘯𝘵 𝘰𝘧 𝘵𝘺𝘱𝘦 2 𝘥𝘪𝘢𝘣𝘦𝘵𝘦𝘴 𝘢𝘮𝘰𝘯𝘨 𝘎𝘳𝘦𝘦𝘯𝘭𝘢𝘯𝘥𝘪𝘤 𝘐𝘯𝘶𝘪𝘵 𝘤𝘢𝘳𝘳𝘪𝘦𝘳𝘴 𝘰𝘧 𝘵𝘩𝘦 𝘛𝘉𝘊1𝘋4 𝘮𝘶𝘵𝘢𝘵𝘪𝘰𝘯.” 𝐂𝐮𝐫𝐢𝐨𝐮𝐬 𝐚𝐛𝐨𝐮𝐭 𝐡𝐨𝐰 𝐭𝐡𝐢𝐬 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐛𝐫𝐢𝐝𝐠𝐞𝐬 𝐩𝐫𝐞𝐜𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐚𝐧𝐝 𝐭𝐫𝐚𝐧𝐬𝐥𝐚𝐭𝐢𝐨𝐧𝐚𝐥 𝐬𝐭𝐮𝐝𝐢𝐞𝐬 𝐭𝐨 𝐭𝐫𝐚𝐧𝐬𝐟𝐨𝐫𝐦 𝐥𝐢𝐯𝐞𝐬? 📖 Read the full article and explore how science is paving the way for personalised health solutions: https://lnkd.in/d6H5y-Eh Rasmus Kjøbsted works at Department of Nutrition, Exercise and Sports by The University of Copenhagen 📷 𝘗𝘩𝘰𝘵𝘰𝘴 𝘣𝘺:Cecilie With #DDEA #DiabetesResearch #PersonalisedMedicine #Exercise
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🌟 𝗚𝘂𝘁 𝗠𝗶𝗰𝗿𝗼𝗯𝗶𝗼𝗺𝗲 𝗮𝗻𝗱 𝗔𝗴𝗶𝗻𝗴: 𝗜𝗻𝘀𝗶𝗴𝗵𝘁𝘀 𝗳𝗿𝗼𝗺 𝗔𝘀𝗶𝗮𝗻 𝗢𝗰𝘁𝗼𝗴𝗲𝗻𝗮𝗿𝗶𝗮𝗻𝘀 🌟 New research highlights the unique shifts in the gut microbiome as people age, specifically within a group of community-living octogenarians in Singapore. This study used advanced metagenomic sequencing to map the microbial species and functions linked to healthy ageing. 🧬 𝗞𝗲𝘆 𝗙𝗶𝗻𝗱𝗶𝗻𝗴𝘀: • 𝗠𝗶𝗰𝗿𝗼𝗯𝗶𝗮𝗹 𝗗𝗶𝘃𝗲𝗿𝘀𝗶𝘁𝘆 𝗖𝗵𝗮𝗻𝗴𝗲𝘀: As individuals aged, certain beneficial bacteria became more prevalent, while others declined. For instance, bacteria like 𝘈𝘭𝘪𝘴𝘵𝘪𝘱𝘦𝘴 𝘴𝘩𝘢𝘩𝘪𝘪 and 𝘉𝘢𝘤𝘵𝘦𝘳𝘰𝘪𝘥𝘦𝘴 𝘹𝘺𝘭𝘢𝘯𝘪𝘴𝘰𝘭𝘷𝘦𝘯𝘴 showed enrichment with age. • 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗣𝗮𝘁𝗵𝘄𝗮𝘆𝘀: Aging microbiomes shifted toward amino acid-based pathways for energy production, stepping back from traditional butyrate-producing bacteria. This shift in metabolic potential may support ageing health by promoting inflammation reduction and other beneficial effects. • 𝗣𝗼𝘁𝗲𝗻𝘁𝗶𝗮𝗹 𝗕𝗶𝗼𝗺𝗮𝗿𝗸𝗲𝗿𝘀 𝗳𝗼𝗿 𝗔𝗴𝗶𝗻𝗴: The study also highlighted microbial markers linked to inflammation, cardiometabolic, and liver health, suggesting the microbiome could serve as a critical biomarker in ageing health. Read more to explore the exciting links between the microbiome and healthy longevity! 📖 https://lnkd.in/erSNbYgg #Microbiome #AgingResearch #HealthyAging #Metagenomics #GutHealth #HealthInnovation #Longevity
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What Role Can The Gut Microbiome Play In Our Aging? #Mysummary Understanding of gut health has evolved in recent years, pointing to the gut's integral role in the aging process and overall health. A recent study showed how the gut microbiome composition shifts with age and how these changes can influence overall health and longevity. Specifically, the study demonstrates that age-related changes in the gut microbiome can lead to increased inflammation and a decline in metabolic functions, which are hallmarks of aging. As we age, the immune cells that populate the GI tract start to dysfunction. They cease to repair damage and become locked into an inflammatory state that erodes the integrity of the GI tract. The modern diet also contributes to this process. It is believed that interventions aimed at modulating the gut microbiome could potentially mitigate some of these negative effects and promote healthier aging. #Mythoughts I have the privilege to serve as a member of the board of directors alongside Dr. Daniel Winer MD, a professor at The Buck Institute for Research on Aging. Dan is a leading figure in the world of gut microbiome research, studying the connection between immune cells in the gastrointestinal tract and the process of aging. His work has been pivotal to science's comprehension of type 2 diabetes, cognitive decline, and more. Together at Propion AKA How to Slow Time, Inc™ we don't claim that we will stop the aging process of Humans, but our goal is to change the way we age with a product that addresses immune cell dysfunction in the GI tract. If you want to be part of this venture, join our WeFunder campaign: https://lnkd.in/e5D-gvpD HAPPY to hear your THOUGHTS and stay POSITIVE! #Myinspiration “To be yourself in a world that is constantly trying to make you something else is the greatest accomplishment.” Ralph Waldo Emerson You can read more about the microbiome and aging here: https://lnkd.in/eYn5Z6mw. #microbiome #science #biology #health #pharma #diet #nutrition #probiotics #therapeutics #startup #biotech
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🤔 Curious what clinical metabolomics is and why your doctor should be using it? ✳️ Metabolites are molecules in your body which are essential for cell and organism functioning. They show how good (or bad) your metabolic pathways are. These are not tested for by standard, conventional medical tests (such as probiotic bacteria and leaky gut markers). ✳️ By analyzing numerous metabolites simultaneously, clinical metabolomics tests {offer/s} insights into how genes, environment, and health interact. It's akin to viewing a city map instead of single buildings, providing a holistic perspective. ✳️ Understanding metabolites helps tailor personalized plans for healing and health optimization. Want to delve deeper into this fascinating field? Check the original post for more information: https://buff.ly/3y4f5ug 💫 Here in Vivacite, we help to find the root causes of health, not disease. To learn more about health optimization, contact us at 09564695988 or visit https://buff.ly/3lFj6eX. All consultations can be done in the safety of your home and office. #metabolomics #betterhealth #optimalhealth #healthybody #evidencebasednutrition #evidencebasedmedicine #prescriptionfree #Selfhealing #Disease #Prohumanbiology #Savethecheerleadersavetheworld #supplements #supplementsthatwork #medicalstudent #medicalschool #medstudent #medschool #medlife #clinicalmteabolomics #healthoptimizationmedicine
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Is NMN an Anti-Aging Agent? www.enochchan01.com 👥 https://lnkd.in/gvyifNHc Nicotinamide mononucleotide (NMN) has garnered significant attention for its potential anti-aging properties. But does the science truly support the hype? Let's delve into the current research and explore what we know so far. NMN is a precursor to NAD+, a coenzyme crucial for various cellular functions, including DNA repair, energy metabolism, and cell signaling. As we age, NAD+ levels decline, and this decrease is believed to contribute to age-related decline. Studies have shown that supplementing with NMN can boost NAD+ levels in some tissues, leading to potential benefits. Some preclinical research suggests that increasing NAD+ levels through NMN supplementation might improve mitochondrial function, protect against age-related diseases, and potentially extend lifespan in certain organisms. However, it's important to note that most of this research has been conducted on animals, and the effects on humans are still being investigated. trials are currently underway to determine the efficacy and safety of NMN supplementation in humans. While early results are promising, more research is needed to fully understand the long-term effects and potential benefits of NMN for anti-aging. It's crucial to approach the topic of anti-aging with a balanced perspective. While NMN shows promise, it's not a magic bullet. Maintaining a healthy lifestyle, including a balanced diet, regular exercise, and stress management, remains essential for healthy aging. Want to learn more about health and wellness? Visit my website for more information: www.enochchan01.com #NMN #AntiAging #NAD #Longevity #Health #Wellness #Science #Research #Biohacking #Supplements #HealthyAging #LifeExtension
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🤔 Curious what clinical metabolomics is and why your doctor should be using it? ✳️ Metabolites are molecules in your body which are essential for cell and organism functioning. They show how good (or bad) your metabolic pathways are. These are not tested for by standard, conventional medical tests (such as probiotic bacteria and leaky gut markers). ✳️ By analyzing numerous metabolites simultaneously, clinical metabolomics tests {offer/s} insights into how genes, environment, and health interact. It's akin to viewing a city map instead of single buildings, providing a holistic perspective. ✳️ Understanding metabolites helps tailor personalized plans for healing and health optimization. Want to delve deeper into this fascinating field? Check the original post for more information: https://buff.ly/3y4f5ug 💫 Here in Vivacite, we help to find the root causes of health, not disease. To learn more about health optimization, contact us at 09564695988 or visit https://buff.ly/3lFj6eX. All consultations can be done in the safety of your home and office. #metabolomics #betterhealth #optimalhealth #healthybody #evidencebasednutrition #evidencebasedmedicine #prescriptionfree #Selfhealing #Disease #Prohumanbiology #Savethecheerleadersavetheworld #supplements #supplementsthatwork #medicalstudent #medicalschool #medstudent #medschool #medlife #clinicalmteabolomics #healthoptimizationmedicine
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At Apeiron Center, we are committed to staying at the forefront of health innovations. A recent study published in NPJ Parkinson's Disease has uncovered critical metabolic disruptions in Parkinson’s disease (PD), revealing new potential treatment pathways. The research shows that patients with PD have significantly lower levels of purine metabolites, such as uric acid, in both serum and cerebrospinal fluid (CSF), challenging prior assumptions about purine metabolism. This study suggests that treatments aimed at simply elevating serum uric acid levels may have limited efficacy. Instead, targeting the purine recycling system, particularly enhancing ATP production, holds more promise. The researchers also plan to explore exercise and nutritional interventions as potential strategies to improve energy metabolism and ATP recycling. These findings bring us one step closer to understanding the complex metabolic changes involved in PD. By focusing on energy metabolism and the purine recycling system, scientists may develop new treatments that not only slow the disease’s progression but also improve the quality of life for patients. #ParkinsonsResearch #MetabolicHealth #EnergyMetabolism #PurineRecycling #HolisticWellness #HealthOptimization #ApeironCenter #ATPProduction #NeurodegenerativeDiseases #Longevity
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🔍 When we talk about metabolic health, we often think about what we eat, how we exercise, or our genes. But there's a factor that is little known by the general population and which is crucial for understanding how our body works: the cell membrane. This incredible structure isn’t just a barrier that protects our cells; it is the world’s best sensor which controls the messages from the inside of the cell to the outside and viceversa. This means that the cell membrane acts as a “sentinel,” regulating what enters and leaves each cell, ensuring that our cells receive the right nutrients and guaranteeing a precise communication intra and extracellular for our organs and tissues to function correctly in time. However, when something goes wrong with this structure, the consequences can be enormous. Imagine the cell membrane as the door of a production factory: if that door doesn’t open or close properly, the ingredients (nutrients) can’t get in, and waste products can’t exit as they should. Communication from the inside or outside the factory is disrupted and messages are erroneous and, over time, this leads to metabolic chaos, which can manifests as disease. At Universal Omics, we deepen into cell membrane study, among other concepts, to understand how its dysfunction can affect our health. Through our in silico analyses, we can more accurately predict how nutraceuticals interact with cells, optimizing their ability to prevent or even reverse metabolic disorders. 🔬 Why is this important? Because by approaching the cell membrane and studying how signals or messages are transmitted, we can identify problems before they manifest as diseases. This approach allows us to develop personalized and effective nutraceuticals, to fix the wrongly given messages and, as a result, re-equilibrate and optimize metabolism. 💡 Health starts at the cellular level, and the membrane is the first line of defense and communication. At Universal Omics, we are leading this new era of prevention and treatment of non-communicable diseases, using the cell membrane as our main ally in the fight for better health. #HealthyMetabolism #NonCommunicableDiseases #Nutraceuticals #Biotechnology #HealthInnovation #PrecisionNutrition #CellHealth #PrecisionMedicine #UniversalOmics #ScienceAndHealth #DiseasePrevention #CellMembrane
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🔬🍏 Breaking Down #metabolichealth through Gut #Microbiome and #metabolomic Research 🧬💡 👨🔬👩🔬 Recent ground-breaking study by Dr. Paula Aranaz at the University of Navarra, Spain reveals key insights on how gut bacteria 🦠 differ between genders, influencing #BMI, waist size, and fat mass. This could reshape #ObesityPrevention strategies to be more gender-specific! 🧐 Key Takeaways: Sex-Specific Bacteria: Men and women show different bacterial strains predictive of obesity metrics. Microbial Impact: Gut flora plays a crucial role in nutrient metabolism, potentially affecting our overall metabolic health. Personalized Interventions: Future obesity interventions might need customization based on individual microbial profiles. 🌍 Presented at #ECO2024 in Venice, Italy, this research pushes the envelope on how we understand and manage obesity and metabolic diseases through tailored interventions. 🥦🚴♀️ Action Point: This study reveals the importance of integrating metagenomics and metabolomics in the study of metabolic diseases. Metabolomic and microbiome tests can be used in clinical practice to identify enterotypes to improve and personalise metabolic health. 🔗Link to abstract in comments below👇 #HealthTech #NutritionScience #MetabolicHealth #InnovativeResearch #PersonalisedMedicine
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Dr. Vanessa Craig, Ph.D. in Biomedical Science and founder of Formettā, is a distinguished researcher and entrepreneur in health and longevity. She has made groundbreaking contributions in understanding the interplay between nutrition, genetics, and aging. Dr. Vanessa Craig’s key findings include: - Inflammation and Aging (Inflammageing): She has highlighted the distinction between acute and chronic inflammation, emphasizing that chronic inflammation accelerates aging and age-related diseases. - Impact of Nutrition on Health and Longevity: Her research supports the importance of a well-balanced, anti-inflammatory diet in promoting healthy aging and mitigating chronic inflammation. - Collagen and Aging: Dr. Craig's studies show that collagen is vital for maintaining youthful skin, strong bones, and joint health. She advocates for collagen supplementation to counteract collagen degradation due to chronic inflammation. Learn more about her insights and innovations here: https://lnkd.in/dAbb_eBs #Health #Longevity #Nutrition #Inflammation #Collagen #Formettà #Wellness
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Natural compounds in gut microbiome show promise for inflammation treatment Researchers at the University of Toronto have discovered naturally occurring compounds in the gut microbiome that can potentially treat inflammation. These compounds interact with the constitutive androstane receptor (CAR), which plays a key role in processing foreign substances and managing inflammation in the liver. The study identified two specific compounds, diindolylmethane (DIM) and diindolylethane (DIE), which regulate CAR without the side effects associated with synthetic compounds, such as liver enlargement. These findings suggest a promising new approach to treating conditions like diabetes, fatty liver disease, and ulcerative colitis using components already present in the human gut. This research not only provides insights into new treatments but also underlines the significant role of gut-produced compounds in health management. Link to Study: https://lnkd.in/dzTpgbsX #microbiome #functionalnutrition #inflammation #guthealth #guthealthmatters #metabolichealth
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