Ārepa’s Post

https://lnkd.in/drM22Bxu I am pleased to share our latest article.  #ptegytk #pharmaceuticalbiology #endometrium #macrophage #fractalkine #cytokines #receptivity #oxidativestress  International Journal of Molecular Sciences MDPI

Geraniol is one of my favorite terps - it's so sweet. I have 4 different types of roses in my garden right now and I'm a huge fan of rolling with petals. Also for all the nerds, yes, technically geraniol is also synthesized from geranyl pyrophosphate and sometimes from other terps, but I have always thought it was cool that cannabinoids are synthesized from the same starting materials as many terps. Way back when they were first being discovered they were very originally described as triterpenoids before gaining their own classification as cannabinoids! Geraniol also has its own therapeutic potential all by itself including antitumor, anti-inflammatory, antioxidant, antimicrobial, hepatoprotective, cardioprotective, neuroprotective, antidiabetic and even antidepressant effects. So when we stop and smell the roses, it’s for a purpose. Some strains high in geraniol are Amnesia Haze, Headband, and Harlequin. It seems to go hand in hand with linalool, another floral terp typically associated with lavender. My obsession with cannabigerol has been ~3.5 years in the making ever since I was first introduced to it! We have some cool preliminary community we collected with Tyler Dautrich and Kevin Provost of MoreBetter, Ltd. that's on a blog I'll link below for those interested. This is just the beginning of our study and another example of how we aim to change the way science is communicated. Instead of holding onto everything and only publishing what is "perfected," we will always be sharing as much of the process with as much transparency as we can. The community feedback we've gotten so far has already helped us make some changes moving forward that will improve what we are doing in the future! Everyone loves #cannabis research, but does everyone prioritize the #community? Follow The Network of Applied Pharmacognosy and join our email list for all the updates!

About new nutraceuticals in the market developed by Elysium Cell Bio ITA (Italian)

Interested in the application of in silico approaches to overcome challenges in drug metabolism? You can find the free recording of our recent webinar on this very subject on our website: https://lnkd.in/dkFDKmd3 Watch it to learn more about: 🔎 The role of drug metabolism and pharmacokinetics (#DMPK) in drug discovery 💊The impacts of drug metabolism 🌟 Addressing challenges in drug metabolism regarding: 1) Cytochromes P450 2) Beyond P450s – the impact of other Phase I and II drug metabolising enzymes 3) Beyond human metabolism – preclinical species #InSilico #DrugMetabolism #ADMET #PredictiveModelling #DrugDiscovery #Pharma

Check out our new review paper "Applications of cell free protein synthesis in protein design" from the Regan, Laohakunakorn and Wells Wood labs and published in Protein Science! 👨🔬 https://lnkd.in/eg32Uqfi Cell free protein synthesis (CFPS) is a rapid, convenient and versatile method to screen for activity and it can be used to screen tens to hundreds of potential protein designs. Additionally, CFPS can evaluate a wider range of activities compared to in vivo protein screening, and it is well-suited for identifying the reasons designs fail (for example problems with transcription, translation and solubility). Let us know what you think! 😊

We have set our products and services related Academic Conference Archive.   Title: Selection of the candidate compound at an early stage of new drug development: retrospective pharmacokinetic and metabolic evaluations of valsartan, an ARB, using common marmosets/新薬開発初期における開発候補品の選択:コモン・マーモセットを用いたアンジオテンシンII受容体阻害剤,バルサルタンの回顧的な薬物動態,代謝に関する評価   Date: November 8–10, 2022   Info: 第37回 日本薬物動態学会 パシフィコ横浜 in Kanagawa, Japan   CLEA product: Marmoset   Keywords: Common Marmoset, Pharmacokinetic, Metabolism, angiotensin receptor blocker : ARB, valsartan   Please click here to see the detail. https://lnkd.in/gvS8sWbR #CommonMarmoset #Pharmacokinetic #Metabolism #angiotensinreceptorblocker #ARB #valsartan

Which buffer should you choose for your next experiment requiring cell lysis? 🤔 Read on! Cell lysis is a critical step for many different types of molecular and cellular assays. These assays rely on solubilizing cellular material like proteins or DNA for analysis, and the quality of the assay performed is based on the efficiency of the extraction of these materials. With multiple lysis buffers to choose from, how do you know which is right for you? Here, we review two frequently used lysis buffers: RIPA (RadioImmunoPrecipitation Assay) and NETN. Did you know we also sell these buffers? More details at the link. https://ow.ly/rmT150Skiek #cellbiology #immunoprecipitation #buffers #celllysis

"Therapeutic and pharmacological applications of extracellular vesicles and lipoproteins" Researchers in the field of extracellular vesicles hate lipoproteins as they always contaminate their samples. But what if EVs and lypoproteins are inseparable pairs and their biological role cannot be revealed without analyzing them together? Does it affect their pharmacological applications as well? It was a pleasure to work together with Prof. Buzas, Krisztina Németh and their group on this review article in which we aim to resolve such questions.

We are thrilled to share our #biocatatlysis work published on JACS. This work describes a human ferritin-based #metalloenzyme catalyzing site-specific #histidinePTMs in proteins designed to set the stage for novel in vivo #EnzymeTherapies. Chemoenzymatic aza-Michael additions on single histidine residues were carried out on 11 different α,β-unsaturated chemicals and eight protein substrates ranging from 10 to 607 amino acids including the insulin peptide hormone. #expandinggeneticcodes #noncanonicalaminoacid #copperenzyme #novelenzyme #sitespecificity #AzaMichaelLigase #proteinPTMs

Welcome to Wednesday Words, where each Wednesday morning I will give you a definition of one word used in biotechnology or biopharma! Glutamine is a non-essential amino acid that plays crucial roles in protein synthesis, nitrogen metabolism, and cellular function. It is the most abundant amino acid in the human body and is involved in various physiological processes, including immune function, intestinal health, and neurotransmitter synthesis. Glutamine serves as a primary fuel source for rapidly dividing cells, such as immune cells and enterocytes, and is important for maintaining cellular integrity and function under stress conditions. Glutamine supplementation is used in clinical settings to support recovery, improve immune function, and enhance athletic performance. If you want to learn more, check out: https://lnkd.in/gQa8yV_N #wednesdaywords #biotechnology #biopharma