DTU Biotech Lifelong Learning’s Post

🔬 Excited to Share Our Latest Publication! 🔬 As a BioEngineer, it was incredible to dive deep into enzyme engineering, optimizing our split trehalase enzyme for a more efficient biosensor platform. This paper is the latest in our lab’s ongoing work to harness trehalase activity, which generates glucose, as a biosensing tool for clinical applications. Special thanks to my former technician, YONGPENG FU, whose talent and dedication made this project a success! Our study focused on addressing two key challenges: optimizing the pH for trehalase function in blood and enhancing activity through hybrid enzyme engineering. By combining fragments from distantly related organisms (Cellvibrio spp. and E. coli), we created hybrids with improved stability and activity in near-physiological conditions—enabling practical, point-of-care applications. Check out the full paper for insights into how we’re pushing the boundaries of enzyme engineering for diagnostics! https://lnkd.in/gXH3VzpR BioEngineering #Diagnostics #EnzymeEngineering #Biosensors #Innovation

🔬 Scientific Monthly Seminar (SMS) with Dr. Patricia Lassaux We were delighted to host Dr. Patricia Lassaux from the Molecular Biomimetic and Protein Engineering Laboratory (MBPEL) at the GIGA - Université de Liège. Her insightful presentation, titled "Unveiling Nature's Secrets: Harnessing Molecular Biomimetics in the ADEKIT-II Project" provided valuable insights into the innovative applications of biomimicry. Dr. Lassaux's visit offered a wonderful opportunity to delve deeper into our shared research project (ADEKIT II) funded by the Greenwin competitivity pole, and explore the potential of biomimicry, particularly in the realm of portable diagnostics. The exchange of ideas was enriching, fostering a deeper understanding of the possibilities in molecular biomimetics. Thanks to our expertise, we can provide technical solutions in engineering and biomanufacturing to unlock the potential of specific peptides and bring new candidates into our partners' pipelines. 🌟 The discussions during Dr. Lassaux's visit have inspired us to continue our collaboration and exploration of new avenues in research. How do you envision contributing to our ongoing efforts in biomimetics and protein engineering? #CERGroupe #Biomimetics #Research #Collaboration #ADEKITII #ScienceCommunity #Protein #Recombinant #PhageDisplay

Register and Participate in the ASSB Knowledge Sharing Webinar Series 2.0 👇👇 It's going to be super interesting as the discussion will delve into the basics and fundamentals of synthetic biology.

제 연구의 처음과 마지막을 네이처 시리즈로 마무리 할 수 있어 크나큰 영광입니다 (lnkd.in/gtTKxF9C) 기초과학연구원과 하버드 MGH의 연구진, 그리고 네이처 에디팅 팀에 깊은 감사를 표합니다. I am honored to have my research journey begin and culminate with the Nature series. I recently published my first-author paper in Nature Reviews Bioengineering, focusing on the lab-to-market strategy for molecular diagnostic platforms. You can find the most recent version here: rdcu.be/dNbj7 This review paper provides practical insights for experts on developing molecular diagnostics platforms using nanomaterials, from the initial development stages to commercialization. It comprehensively covers the physical and chemical properties of target-specific materials, FDA approvals, medical and environmental regulations, and ISO certification, offering real-world solutions for commercial viability. This may very well be my final scientific paper. I extend my heartfelt gratitude to the Institute for Basic Science and Harvard MGH professors for their support, and to the Nature publishing team for their tireless efforts and countless revisions to ensure a successful publication.

𝟯️⃣ [ 𝗧𝗛𝗘 𝗩𝗛𝗛 𝗧𝗢𝗢𝗟𝗕𝗢𝗫 ] 𝗨𝗻𝗹𝗼𝗰𝗸𝗶𝗻𝗴 𝗻𝗲𝘄 𝗶𝗻𝘀𝗶𝗴𝗵𝘁𝘀 𝗶𝗻 𝗧𝗮𝘂 𝗳𝗼𝗹𝗱𝗶𝗻𝗴 𝗮𝗻𝗱 𝘀𝘁𝗿𝘂𝗰𝘁𝘂𝗿𝗮𝗹 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀 𝘄𝗶𝘁𝗵 𝗼𝘂𝗿 𝗡𝗮𝗻𝗼𝗯𝗼𝗱𝗶𝗲𝘀®🔬    Our 𝗩𝗛𝗛 𝗧𝗼𝗼𝗹𝗯𝗼𝘅 continues to push boundaries in the field of Tau research! This spring, our synthetic nanobodies were highlighted in the Journal of Biological Chemistry (April 2024). The study from Isabelle Landrieu’s lab and collaborators explores how these nanobodies provide crucial insights into Tau folding, structural dynamics, and activity relationships. ➡️ 𝗪𝗵𝗮𝘁’𝘀 𝗡𝗲𝘅𝘁? We’re excited to share that more VHHs are in development! Clément DANIS and Elian Dupre, with the support of our PhD network European Network TauImmune, are working on new anti-Tau nanobodies that will further expand the capabilities of our toolbox.  𝗘𝘅𝗽𝗹𝗼𝗿𝗲 𝗼𝘂𝗿 𝗶𝗻𝗻𝗼𝘃𝗮𝘁𝗶𝗼𝗻𝘀 𝗮𝗻𝗱 𝘀𝗲𝗲 𝗵𝗼𝘄 𝗼𝘂𝗿 𝗰𝘂𝘁𝘁𝗶𝗻𝗴-𝗲𝗱𝗴𝗲 𝗻𝗮𝗻𝗼𝗯𝗼𝗱𝗶𝗲𝘀 𝗰𝗮𝗻 𝗯𝗼𝗼𝘀𝘁 𝘆𝗼𝘂𝗿 𝗽𝗿𝗼𝗷𝗲𝗰𝘁 ! 🔗 https://lnkd.in/eKYNXnDv #Innovation #Biotechnology #Nanobodies #Tau #ScientificResearch #HybrigenicsServices #SyntheticNanobodies #TauResearch 

Excited to share our latest research in ACS Applied Bio Materials. Check out our paper

"Excited to share our team's vlog on the fundamentals of real-time PCR! Learn about this powerful technique used in research and diagnostics. #realtimePCR #molecularbiology #sciencecommunication" LPU School of Bio Engineering and Biosciences, Lovely professional University.

Did you notice that the title of our event has changed to BIOENERGY AND BIOBASED PRODUCTS? This year #DOC2024 is extending its thematic scope to include #research on #biomass-based products, reflecting current #political and #economic developments and following the comments and recommendations of our Scientific Advisory Board from the survey we conducted at the end of February 2024... We hope, you like it or leave a comment below 😉 www.doc-bioenergy.de #doc_BIOENERGY #PhD #Doctoral #YoungScientists

🧬 𝗥𝗲𝗽𝗼𝗿𝘁𝗶𝗻𝗴 𝗳𝗿𝗼𝗺 𝘁𝗵𝗲 𝗦𝘆𝗻𝘁𝗵𝗲𝘁𝗶𝗰 𝗮𝗻𝗱 𝗘𝗻𝗴𝗶𝗻𝗲𝗲𝗿𝗶𝗻𝗴 𝗕𝗶𝗼𝗹𝗼𝗴𝘆 𝗕𝗿𝗶𝘁𝗶𝘀𝗵-𝗦𝘄𝗶𝘀𝘀 𝗦𝘂𝗺𝗺𝗶𝘁 𝗶𝗻 𝗕𝗿𝗶𝘀𝘁𝗼𝗹 Our CSO, Dr. Frank Plöger, was participating as a panelist at the prestigious Synthetic and Engineering Biology British-Swiss Summit in Bristol. This summit is a collaborative initiative, bringing together academic and industry leaders from the UK and Switzerland to explore cutting-edge developments in synthetic and engineering biology. During the session on Bioprocessing and Scale-Up, Frank and fellow experts delved into critical topics, including: 🔹 How rapid advancements in synthetic and engineering biology are expanding the possibilities of bioprocess technologies in the healthcare space. 🔹 Current challenges in bioprocessing concerning new modalities and the complexities of reproducibility and standards/metrology. 🔹 Scale-up challenges from an investment perspective. 🔹 Educating and collaborating with relevant communities, including academics, to address knowledge and skills gaps in bioprocessing and scale-up. We are thrilled to contribute to these important discussions and look forward to continuing our efforts in bridging the gap between research and development in the life sciences. Special thanks to Anike Te from Lucideon for the invitation 👏 Tim Heinemann Oliver Dovey Helen Stubbs Pugin #SyntheticBiology #EngineeringBiology #Bioprocessing #HealthcareInnovation #Biotechnology #LifeSciences #Innovation #Investment

Check out this seminar on our work within engineered cell-cell communication for uses in cancer immunotherapy (CAR T cells) and fungal interactions in relation to agriculture, by Emil Damgaard Jensen! ✨ Giovanni Schiesaro  DTU Biosustain  Novo Nordisk Foundation DTU - Technical University of Denmark