Ed Learno’s Post

Glad to share our latest article on the elimination of the paternal mitochondria:

Did you know the term "Moon blindness” was first used to describe equine recurrent uveitis (ERU) in the 1600s when people thought that the moon's phases correlated with repeated episodes of temporary blindness in their horses? Now we know that what actually causes ERU is complex and likely multi-factorial but points to a genetic predisposition to autoimmune issues that correlate to external triggers. Likely a combination of genetics, environmental factors, and the underlying cause of the original episode are involved. Click the link below to learn more about Moon blindness, what to look out for, and what can be done to help the affected equine. https://lnkd.in/gGy-E-rE #PlatinumPerformance #ItStartsWithin #EquineHealth

For the cross AaBbCCdd x AabbCcDd, what are the odds of getting offspring with the recessive... In genetics, probability is a measurement tool that helps us predict the chances of an offspring being inherited with a particular trait of interest. In diploid organisms, during the formation of gametes by the process of meiosis there is a 50% chance for each of the chromosomes to get passed on to the gamete. Problems: In dogs, black coat color (B) is dominant to yellow coat color (b), and straight fur (C) is dominant to curly fur (c). The coat color gene and the fur texture gene are on different chromosomes, so they assort independently, and are not sex linked. In a cross between two BbCc parents, predict the fraction of offspring with black coat color and straight fur. In a cross between two BbCc parents, predict the fraction of offspring with black coat color and straight fur. A) 9/16* B) 3/4 C) 15/16 D) 1/16 For the cross AaBbCCdd x AabbCcDd, what are the odds of getting offspring with the recessive phenotype for all four traits? A) 0* B) 1/16 C) 1/32 D) 1/64 #genetics #probability #statistics Youtube video: https://lnkd.in/dtPGVgea #nikolaysgeneticslessons

Genetic transformation of maize (Zea mays L.) using scutellar tissue of immature embryo mediated by Agrobacterium tumefaciens - https://smpl.is/9nugr

How to solve Ploidy problems in genetics A chromosome is a long DNA molecule with part or all of the genetic material of an organism. Most eukaryotic chromosomes include packaging proteins called histones which, aided by chaperone proteins, bind to and condense the DNA molecule to maintain its integrity. Youtube video: https://lnkd.in/d_-W7cMB #nikolaysgeneticslessons

Consequence of Gamma Radiation Induced Cytomixis during Microsporogenesis in Fennel Plant (Foeniculum vulgare Mill.) https://lnkd.in/egtwqRn9 #cytomixis #Foeniculumvulgare #gammaradiation #pollenfertility #syncytes #Foeniculum Abstract Fennel is considered as a very important spice crop with powerful therapeutic potential. An improvement in this valuable crop, selected physical mutagen (Gamma irradiation) on the seeds with five selective doses viz., 50, 100, 150, 200 and 250 Gy for break genetic consistency in narrow genetic base in Fennel crop, remunerative phenomenon of syncytes was seen in some cases, where complete chromatin was transmitted to the recipient PMC, that generates dimorphic pollen grain. Such pollen grain with varying genetic content plays a significant role in the emergence of intraspecific polyploidization of species. A curious biological process which is often observed in microsporogenesis of higher plants like, development of syncytes, cytomixis between plant cells and due to this the creation of big pollen has evolutionary relevance. The cytomictic behaviour of Foeniculum vulgare Mill. has been reported in this experiment. Keywords:  cytomixis Foeniculum vulgare gamma radiation pollen fertility syncytes Foeniculum

There are dwarfs in triticale, too ... ... and they suffer more from Fusarium head blight! A new study of 158 progeny of the cross Cando (short) x Tritikon (tall) clearly shows a higher susceptibility of the short subpopulation. This susceptibility QTL is associated with the same DNA marker than plant shortness on rye chromosome 5R and caused by the dominant dwarfing gene Ddw1. Paper coming soon in PLANT BREEDING... https://lnkd.in/eMDcfraX

How to find how many loci control a trait? (Quantitative Genetics) Most of the phenotypic characteristics that distinguish different individuals within a natural population are not of the all or none variety associated with laboratory-bred mouse mutations like albino, non-agouti, brown, quaking, Kinky tail, and hundreds of others. On the contrary, easily visible human traits such as skin color, wavy hair, and height, as well as hidden traits such as blood pressure, musical talent, longevity, and many others each vary over a continuous range of phenotypes. These are "quantitative traits," so-called because their expression in any single individual can only be described numerically based on the results of an appropriate form of measurement. Quantitative traits are also called continuous traits, and they stand in contrast to qualitative, or discontinuous, traits that are expressed in the form of distinct phenotypes chosen from a discrete set. Continuous variation in the expression of a trait can be due to both genetic and non-genetic factors. Non-genetic factors can be either environmental (in the broadest definition of the term) or a matter of chance. In mice, it is relatively straightforward to separate genetic from non-genetic contributions through the analysis and comparison of animals within and between inbred strains. Variation in expression among individual members of an inbred strain must be caused by non-genetic factors. Furthermore, if one is convinced that all individuals are maintained under identical environmental conditions, then existing variation is likely to be the result of chance alone. Youtube video: https://lnkd.in/dy42qdMF #nikolaysgeneticslessons

We are pleased to announce this special issue "Retinal Pigment Epithelial Cells in Age-Related Macular Degeneration" launched in Cells. If you are interested in this topic and would like to contribute to us, please feel free to contact us (katrina.wang@mdpi.com). We are looking forward to receiving your submission. 📃Guest Editor: Dr. Sujoy Bhattacharya 📃Deadline: 1 August 2024 📃Special Issue Information: This Special Issue will examine novel regulators stimulating an intrinsic regenerative response in the mature RPE, methods to isolate and maintain RPE cells isolated from rodents and human donor eyes, age-related changes in RPE mitochondrial function, metabolic pathways, and extracellular matrix reorganization, transcriptomic and proteomic analyses of iPSC-derived RPE, and novel animal models recapitulating hallmarks of aAMD pathobiology. 📃Keywords: atrophic age-related macular degeneration; iPSC-derived RPE; animal models 📃Read more about this Special Issue: https://lnkd.in/gb3DnxWs #mdpi #cells #Age Related Macular Degeneration #research

How Meiosis Shapes Life Cell division is the cornerstone of life, but when it comes to genetic diversity, meiosis takes the spotlight. Unlike mitosis, meiosis is a masterful process that reduces the chromosome number by half, paving the way for gametes to form and ensuring every new organism is genetically unique. Here’s why meiosis is a marvel: 1️⃣ Two Phases, One Goal: Meiosis consists of Meiosis I (homologous chromosomes separate) and Meiosis II (sister chromatids separate), resulting in four non-identical daughter cells. 2️⃣ Genetic Shuffling: Processes like crossing over and independent assortment during Prophase I are what make each individual one-of-a-kind, fueling evolution. 3️⃣ Biological Significance: From ensuring genetic diversity in populations to preventing chromosomal abnormalities, meiosis is vital for the survival and adaptability of species. Think about it: every unique feature you have—your eye color, hair texture, and even your resilience to certain diseases—is a testament to the elegance of meiosis. #Meiosis #CellDivision #GeneticDiversity #BiologyMatters #ScientificBreakthroughs