EKTAH’s Post

Groundbreaking research from the University of Virginia School of Medicine has identified critical biomarkers in blood samples that could revolutionize the early detection and prevention of Sudden Infant Death Syndrome (SIDS). The significance of this research lies in its potential to develop a simple blood test that could identify infants at heightened risk. Such a breakthrough could enable targeted interventions and proactive monitoring.

Next Monday (20 January), Claudia Schoenichen will defend the thesis ‘A jack of all trades: Platelets at the interface of endothelial inflammation and coagulation’ at 16.00h @ Maastricht University This PhD project was part of the Horizon 2020 ITN TICARDIO and results in a double doctorate between Maastricht University and the Johannes Gutenberg University Mainz of Mainz. ➡️ Platelets are essential for preventing bleeding, but in cardiovascular and inflammatory disorders, their dysregulation increases thrombotic risks. Beyond their clotting role, platelets function as immune cells, offering novel therapeutic targets. This research explores the interactions of activated platelets in thrombosis, immune function, and endothelial inflammation.  First, using an in vitro arterial thrombosis model, it was found that activated integrin αIIbβ3 suppressed neutrophil adhesion, while platelet CD40L influenced neutrophil movement. Chemokines from platelets triggered calcium signaling in neutrophils, blocked by prostacyclin. Activated neutrophils formed neutrophil extracellular traps (NETs) only under specific conditions. Second, the study examined store-operated calcium entry (SOCE) in platelets, regulated by ORAI1 channels and influenced by PKC isoforms. Genetic defects in SOCE components impaired calcium signalling. Finally, endothelial cells were studied to uncover their role in platelet regulation. Inflammatory stimuli disrupted endothelial antithrombotic mechanisms, altering platelet activation and coagulation pathways.    Supervisor: Prof. Johan Heemskerk Co-supervisors: Dr Marijke Kuijpers Dr Kerstin Jurk (Johannes Gutenberg University of Mainz) #carimmaastricht #maastrichtuniversity  #phdlife #phddefence 📺 https://lnkd.in/gyxQm23g

Our first scientific article of 2025 was published today! Today, MDPI published our article “#AdipoRon’s Impact on #Alzheimer’s Disease—A #Systematic #Review and #Meta-#Analysis” in the International Journal of Molecular Sciences MDPI. This represents a collaborative effort between researchers from #Brazil and #Hungary with different affiliations. Alzheimer’s disease leads to cognitive decline. Despite advancements in early detection, diagnosis, and treatment, Alzheimer’s disease presents substantial challenges due to its complex pathology. Consequently, there is a pressing need for novel therapeutic agents. AdipoRon, an adiponectin receptor agonist, has garnered interest for its potential neuroprotective effects, including reducing neuroinflammation, improving mitochondrial function, mitigating tau hyperphosphorylation, and improving cognition. I want to #thank everyone involved in writing, reviewing, editing, and publishing this paper. I especially want to thank Professor Sandra Barbalho from the Universidade de Marília and Professor Masaru Tanaka from the University of Szeged for their guidance and expertise. I also want to thank my coauthors, Jesselina Haber and Victória Dogani, for always embracing our projects. The link for our publication is below. https://lnkd.in/dSz_gi3y Thank you to everyone! Bye!

My work from a previous postdoc at UT Southwestern Medical Center, Dallas-TX, USA, is on BioRxiv. please see: https://lnkd.in/d7fBreeG As an external mucosal surface, the corneal epithelium is subject to a barrage of stressors that are known to trigger inflammation. IL-1β, a master regulator of inflammation, is secreted into the preocular tear film by ocular surface epithelial cells and infiltrating immune cells. While increased levels of IL-1β have been associated with corneal disease, the effects of IL-1β on mitochondrial function in corneal epithelial cells (CECs) is unknown. Short term exposure to IL-1β triggered an increase in IL-8 and ROS levels that corresponded to a reduction in mitochondrial membrane potential. Long term exposure also showed increased levels of IL-8 and IL-6 and further increased ROS. After long term exposure however, there was a paradoxical increase in mitochondrial membrane potential that was associated an increase in spare respiratory capacity and mitochondrial hyperfusion. Metabolomics confirmed an upregulation of the pentose phosphate pathway and the TCA cycle. Fumarate was also increased, suggesting an increase in flux through complex II. Changes in lipid metabolism included an upregulation in cardiolipin and de novotriacylglyceride biosynthesis, along with increasing numbers of lipid droplets. In conclusion, prolonged exposure to IL-1β induces metabolic rewiring in CECs that results in an increase in spare respiratory capacity. These findings suggest that the corneal epithelium is able to adapt to certain levels of chronic inflammation and may have important implications in our understanding of immune tone and cellular stress responses in ocular surface epithelia.

On April 16, #BGI-Research announced the publication of two joint studies conducted by the Chinese Academy of Sciences Center for Excellence in Molecular Cell Science (CEMCS) in collaboration with the Jilin University, Istituto Tumori 'Giovanni Paolo II' Bari - IRCCS, University of Copenhagen (Københavns Universitet), Chulalongkorn University, University of Cambridge, Hannover Medical School, and other Chinese and international institutions. Together, both studies form a comprehensive liver reference atlas that addresses various aspects of #liver #injury and #regeneration. These findings have the potential to uncover underlying mechanisms and targets for promoting the regeneration of region-specific liver injuries. Moreover, they establish a new research framework for studying the intricate mechanisms of injury and regeneration in other tissues that exhibit heterogeneous distribution patterns. Both studies employed BGI's proprietary high-resolution and large field-of-view spatial multi-omics technology (Stereo-seq) in combination with single-cell transcriptome sequencing technology, resulting in ground-breaking discoveries that were published online today and will be in print on the May issue of Nature Genetics. Read more: https://bit.ly/3vKGd0D

Destination Albuquerque: Previewing the 1st International Conference on Steroid Hormones and Receptors "Endocrine News talks to conference chairs Eric R. Prossnitz, PhD, and Carol A. Lange, PhD, about what attendees can expect, topics to be covered, and why the sessions should appeal to both endocrine scientists and clinicians. Building on 25 years of highly successful conferences, SHR is an international biomedical conference that aims to explore state-of-the-art advances in steroid hormone and receptor functions, both rapid and genomic, in various aspects of biology and medicine in terms of normal physiology and pathophysiology.” Read more in Endocrine News: https://bit.ly/3YQt7e9 #SHR2024 #steroidreceptors #steroidhormones #hormeonscience

Submissions are now OPEN!! This Research Topic aims to explore the multifaceted roles of cytoskeletal networks in the spatiotemporal regulation of metabolism and disease progression. We welcome contributions that delve into the interactions between the actomyosin cytoskeleton, signaling networks, membrane dynamics, and their collective impact on metabolic processes, bioenergetics, and disease progression. Specific themes of interest include but are not limited to the molecular mechanisms underlying cytoskeletal regulation of metabolism, the influence of cytoskeletal dynamics on cellular energy production, and the contribution of cytoskeletal alterations to disease pathology. https://lnkd.in/eEFKawwS

SBRG is pleased to announce an acceptance of an abstract on predictive bio-analytics for the Conference on Innovation in Biomarkers (Scientific Secretariat Journées de l’innovation en biologie) November 7-8, 2024 in Paris, France. SBRG conducted research with our development and business partner, Numa Health International (France) using data obtained from a prior study with the department of cardiology at Lithuania State Medical University. Using SBRG’s proprietary biomarker drift-cluster analysis approach and NUMA’s machine learning expertise, we developed a model predicting two year risk of major adverse cardiac events (MACE) after a first myocardial infarction. What was significant about the study was the use of factors non-specific for cardiovascular dysfunction. This would be a disruption in the medical model because it re-contextualizes the diseased organ within the global context of the whole person and the systemic adaptation response.    This is highly significant not only for MACE prediction, but also demonstrates the strength and value of the complex systems approach of Endobiogeny. We look forward to this accomplishment encouraging more studies in global systems methodologies and their practical application in medicine. The potential to expand medicine with the global living systems theory and endobiogeny are palpable.  Contact our Chief Scientific Officer, Kamyar Hedayat, MD for more information and to explore research opportunities. Read the full abstract translated into English by following the link below. https://lnkd.in/gMGRyWRy

We are excited to spotlight work from Stanford Cardiovascular Institute (CVI) researchers using human-induced pluripotent stem cells (iPSCs) to delve into the cardiovascular effects of nicotine. This innovative study sheds light on how human induced pluripotent stem cell-derived endothelial cells (iPSC-ECs) can be a tool for understanding the effect of nicotine on cardiovascular health. This study used cells from a diverse group of donors to show that while the effects from nicotine were consistent across individuals, ancestry-specific responses suggested a nuanced interplay between genetics and toxin susceptibility.Learn more about how cutting-edge science is helping us better understand the impact of substances on heart health and paving the way for targeted therapeutic strategies. https://lnkd.in/g3UbqtjB

Exciting News for Our Institute!  I am proud to announce that Prof. Dr. Igor G. Bondarenko, Senior Researcher at the Medical Institute for Nutrition Science and Technology, has co-authored a groundbreaking article that has been published in the prestigious Journal of Orthomolecular Medicine. 🏆 The article, titled “Targeting the Mitochondrial Stem Cell Connection in Cancer Treatment: A Hybrid Orthomolecular Protocol,” is a collaborative effort with international experts and marks a significant milestone in our ongoing research at the institute. This publication not only highlights the innovative work being done in orthomolecular medicine but also strengthens our position in the global scientific community. 🌍 We are incredibly proud of Prof. Dr. Bondarenko and his contribution to this important field of study. This success reflects our commitment to advancing medical research and pushing the boundaries of what’s possible. You can read more about this achievement and access the full article here: https://lnkd.in/gP5PRDgn #research #orthomolecularmedicine #cancerresearch #publication #teamwork #innovation #medicalscience #proudmoment