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📃Scientific paper: Aneurysm Treatment with Woven EndoBridge-17: Angiographic and Clinical Results at 12 Months from a Retrospective, 2-Center Series Abstract: BACKGROUND AND PURPOSE: This retrospective, 2-center study investigated the feasibility, safety, and efficacy at 12-month follow-up of the treatment of ruptured, unruptured, and recurrent intracranial aneurysms using the latest generation of the Woven EndoBridge (WEB) device, the WEB-17 system. MATERIALS AND METHODS: Aneurysms treated with WEB-17 were extracted from the databases of 2 neurovascular centers. Patients, aneurysm characteristics, complications, and clinical and anatomic results were analyzed. RESULTS: From February 2017 to May 2021, two hundred twelve patients with 233 aneurysms (181/233, 77.7%, unruptured-recurrent, and 52/233, 22.3%, ruptured) were included. High treatment feasibility (95.3%) was reported and was similar in ruptured aneurysms (94.2%) and unruptured-recurrent aneurysms (95.6%) (P = .71) and in typical (95.4%) and atypical (94.7%) locations (P = .70), but it was lower in aneurysms with an angle between the parent artery and main aneurysm axis of ≥45° (90.2%) compared with those with an angle of <45° (97.1%) (P = .03). Global mortality and morbidity were 1.9% and 3.8% at 1 month, respectively, and 4.4% and 1.9% at 12 months, respectively. One-month morbidity (P = .02) and mortality (P = .003) were higher in the ruptured group (10.0% and 8.0%, respectively) compared with unruptured-recurrent group (1.9% and 0.0%, respectively). Overall adequate occlusion (complete occlusion and neck remnant) was 86.3%. The percentage of adequate occlusion... Continued on ES/IODE ➡️ https://etcse.fr/ZMOGt ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: Aneurysm Treatment with Woven EndoBridge-17: Angiographic and Clinical Results at 12 Months from a Retrospective, 2-Center Series Abstract: BACKGROUND AND PURPOSE: This retrospective, 2-center study investigated the feasibility, safety, and efficacy at 12-month follow-up of the treatment of ruptured, unruptured, and recurrent intracranial aneurysms using the latest generation of the Woven EndoBridge (WEB) device, the WEB-17 system. MATERIALS AND METHODS: Aneurysms treated with WEB-17 were extracted from the databases of 2 neurovascular centers. Patients, aneurysm characteristics, complications, and clinical and anatomic results were analyzed. RESULTS: From February 2017 to May 2021, two hundred twelve patients with 233 aneurysms (181/233, 77.7%, unruptured-recurrent, and 52/233, 22.3%, ruptured) were included. High treatment feasibility (95.3%) was reported and was similar in ruptured aneurysms (94.2%) and unruptured-recurrent aneurysms (95.6%) (P = .71) and in typical (95.4%) and atypical (94.7%) locations (P = .70), but it was lower in aneurysms with an angle between the parent artery and main aneurysm axis of ≥45° (90.2%) compared with those with an angle of <45° (97.1%) (P = .03). Global mortality and morbidity were 1.9% and 3.8% at 1 month, respectively, and 4.4% and 1.9% at 12 months, respectively. One-month morbidity (P = .02) and mortality (P = .003) were higher in the ruptured group (10.0% and 8.0%, respectively) compared with unruptured-recurrent group (1.9% and 0.0%, respectively). Overall adequate occlusion (complete occlusion and neck remnant) was 86.3%. The percentage of adequate occlusion... Continued on ES/IODE ➡️ https://etcse.fr/ZMOGt ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

Opportunity to add your name in the research paper as co-author Title:1 Insulin Treatment and Metabolic Control in Diabetes: Exploring Influential Factors in Hospitalized Patients" Title:2 Exploring the Connection Between Chronic Stress and Cardiovascular Diseases: Insights from the Mediterranean Diet Title 3 The Role of Coronary Bypass Surgery in Reducing Mortality and Enhancing Quality of Life among Heart Disease Patients Title:4 UNVEILING RISKS: IDENTIFYING WARNING SIGNS FOLLOWING BARIATRIC SURGERY. Title:5 OPTIMIZING HOSPITALIZED PATIENT CARE: THE SIGNIFICANCE OF DENTAL CARE IN ICU SETTINGS Title:6 ENHANCING PATIENT CARE: PHARMACOTHERAPEUTIC MONITORING IN COMMUNITY PHARMACIES. Title:7 EXAMINING CD133, C-MYC, AND AXL EXPRESSION IN COLON ADENOCARCINOMAS: PROGNOSTIC VALUE AND CLINICAL ASSOCIATIONS Title:8 EVALUATION OF BIOCHEMICAL METHODS FOR BACTERIAL IDENTIFICATION: INSIGHTS FROM MICROPLATE ASSAYS Title:9 EXPLORING THE IMPACT OF DIALYSIS ON NEUROLOGICAL CONDITIONS: INSIGHTS FROM BIOCHEMICAL DATA IN CHRONIC KIDNEY DISEASE Title:10 ENHANCING PATIENT SAFETY THROUGH MEDICATION RECONCILIATION AND DISCHARGE ADVICE: A PROSPECTIVE STUDY IN A SMALL HOSPITAL SETTING Paid Slots Available Dm for more details by clicking the link https://wa.link/rla2h8

📃Scientific paper: Replacement of long-segment ureteral defect with tapered demucosalized ileum: medium-term outcomes of 4 patients Abstract: Purpose Repair of long-segment ureteral defect (LSUD) is challenging. Currently available procedures carry some potential complications. We modified the ileal graft by tapering the wall and stripping the mucosa to combat associated pitfalls and first reported the medium-term outcomes of 4 patients. Material and methods From September 2019 to October 2020, tapered demucosalized ileum (TDI) was used for LSUD reconstruction in 4 patients on the right (2 males and 2 females). Two patients were with panureteral avulsion and 2 with high-risk urothelial carcinoma in the distal ureter. TDI was made by tapering 1/2–2/3 of the antimesenteric ileal wall and stripping the mucosa with a blunt/blunt operating scissor. Follow-up modalities included serum creatinine, electrolytes, ultrasonography, CT urogram, renal scintigraphy, and ureteroscopy. Results Mean operation time was 443 min (range 360–550) and blood loss was negligible. The mean follow-up period was 29 months (range 23–36). Vesicoureteral reflux and related pyelonephritis occurred in 1 patient, necessitating a repair operation (Clavien-Dindo grade IIIb). No strictures, obstructions, metabolic disorders, or electrolyte imbalances were observed in the remaining patients. In carcinoma patients, ureteroscopy in month 18 post-operation revealed ileal mucosal regrowth in the form of dwarf isolated islands. All renal units maintained adequate drainage and function during the follow-up. Conclusions Ileal wall tapering and ... Continued on ES/IODE ➡️ https://etcse.fr/DmZC ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

❤️🧲 The study evaluates mitral valve orifice area as a predictor of outcomes following biventricular repair in patients with hypoplastic left ventricles (HLV). Conducted at Boston Children’s Hospital, this single-center retrospective analysisinvolved 122 patients with HLV who underwent biventricular repair between 2005 and 2022. The focus was on preoperative cardiovascular magnetic resonance (CMR) measurements of the mitral valve (MV) orifice area during diastole. Key findings include: 1.The study identified a low MV orifice area and pre-existing MV pathology as significant risk factors for adverse outcomes post-biventricular repair. Primary composite outcomes were analyzed, including death, transplant, biventricular takedown, heart failure admission, left atrial decompression, or unexpected reoperation. 2.The median follow-up was 0.7 years, with a primary outcome freedom rate of 53% for atrioventricular canal (AVC) patients and 69% for non-AVC at two years. 3.Secondary outcomes focused on ≥ moderatemitral stenosis or regurgitation, showing a freedom rate of 49% for AVC and 79% for non-AVC at two years. 4.Independent predictors of adverse primary outcomes included MV orifice area z-score < -2, transitional AVC for AVC patients, and abnormal MV anatomy and conal-septal ventricular septal defect for non-AVC patients.This study highlights the critical role of MV orifice area in predicting outcomes in HLV patients undergoing biventricular repair, suggesting that detailed preoperative CMR evaluation of the MV is essential for optimal surgical planning and risk assessment. Dr. Kolandaivelu explains below. Full text available here 👉 https://lnkd.in/gms8HM7C

📃Scientific paper: Intrathyroid Injection of Steroid in Benign Thyroid Swellings Abstract: INTRODUCTION: Benign thyroid swelling disorders are common conditions, frequently encountered in clinical practice. Though medical management has been useful in treating the hormonal variations, it has not been very significant in reducing the size of the swelling. OBJECTIVE: To study the efficacy of intra thyroid injection of triamcinolone in benign thyroid swelling disorders. MATERIALS AND METHODS: A total of 20 patients were selected for this study. All the patients with thyroid swellings, were evaluated with history and clinical examination followed by routine blood investigations, thyroid function tests (T3,T4,TSH), Fine Needle Aspiration Cytology (FNAC) and Ultrasonography (USG) of the neck. The treatment adopted in this study was intrathyroid injection of triamcinolone acetonide. RESULTS: In this study there were 20 patients, all were females in the age group of 17- 55 years. Four patients did not come for regular follow up, and hence were excluded. Sixteen patients were followed up regularly. Thirteen (81.25 %) patients showed excellent results with no visible swelling, confirmed sonologically. Two patients (12.5%) showed fair results with residual swellings, and one patient did not show any reduction in size of the swelling. CONCLUSION: Intrathyroid injection of triamcinolone acetonide is a safe, minimally invasive technique in reducing the size of benign thyroid swellings with minimal or no side effects. Continued on ES/IODE ➡️ https://etcse.fr/1HTy ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

❤️🧲 The study evaluates mitral valve orifice area as a predictor of outcomes following biventricularrepair in patients with hypoplastic left ventricles (HLV). Conducted at Boston Children’sHospital, this single-center retrospective analysisinvolved 122 patients with HLV whounderwent biventricular repair between 2005 and 2022. The focus was on preoperativecardiovascular magnetic resonance (CMR) measurements of the mitral valve (MV) orifice areaduring diastole.Key findings include: 1.The study identified a low MV orifice area and pre-existing MV pathology as significant risk factors for adverse outcomes post-biventricular repair. 2. Primary composite outcomes were analyzed, including death, transplant, biventriculartakedown, heart failure admission, left atrial decompression, or unexpected reoperation. 3. The median follow-up was 0.7 years, with a primary outcome freedom rate of 53% foratrioventricular canal (AVC) patients and 69% for non-AVC at two years. 4. Secondary outcomes focused on ≥ moderatemitral stenosis or regurgitation, showing afreedom rate of 49% for AVC and 79% for non-AVC at two years. 5. Independent predictors of adverse primary outcomes included MV orifice area z-score <-2, transitional AVC for AVC patients, and abnormal MV anatomyand conal-septalventricular septal defect for non-AVC patients.This study highlights the critical role of MV orifice area in predicting outcomes in HLV patientsundergoing biventricular repair, suggesting that detailed preoperative CMR evaluation of theMVis essential for optimal surgical planning and risk assessment. Dr. Liddle explains below. Full text available here 👉 https://lnkd.in/g8ZDPA6K

Did you know? At MAC, we specialise in a range of clinical procedures including biopsies, arthrocentesis, and lumbar punctures. For example, a skin punch biopsy allows us to remove a small sample of skin tissue under local anesthesia. It’s a quick, low-impact procedure that helps us identify biomarkers and monitor microscopic skin changes. Similarly, we perform muscle biopsies using either an open surgical method or a percutaneous technique, where a needle extracts a small muscle sample. These biopsies are invaluable for identifying specific biomarkers and assessing neuromuscular conditions. In the case of liver conditions such as NASH or cirrhosis, we rely on ultrasound-guided liver biopsies. By using ultrasound to guide a needle for tissue extraction, we can precisely monitor liver health and treatment efficacy with minimal risk to patients. For joint issues, we perform arthrocentesis, where synovial fluid is collected from the knee or other joints. This procedure helps identify biomarkers and assess conditions like gout or arthritis while providing key insights into investigational treatments. Lastly, our lumbar puncture (spinal tap) allows us to collect cerebrospinal fluid, aiding in the study of neurological biomarkers. This procedure helps us understand disease progression and treatment outcomes with a high degree of accuracy. These procedures play a pivotal role in advancing research while prioritising patient well-being and comfort. Contact us to find out how we can support your study: https://lnkd.in/dFPZVcHj #ClinicalResearch #Biomarkers #InnovativeHealthcare #ClinicalTrials #CRO

🧠 Mastering Intracerebral Hemorrhage (ICH) Management 🧠 Check out this comprehensive slide summarizing critical targets for managing intracerebral hemorrhage (ICH). Kudos to Victor J. Del Brutto, MD, MSc for creating such an insightful visual that breaks down the layered approach needed in ICH care! 📊👏 🔍 Treatment Targets Breakdown: ⭐ Primary Goal: Limit Hematoma Expansion The first and foremost goal in ICH management is to curb hematoma expansion, as early stabilization can significantly impact outcomes. Strategies here emphasize rapid blood pressure (BP) control and hemostatic therapy. 💉 Key Interventions: 1️⃣ Blood Pressure Reduction: • Post-hoc analyses from studies like INTERACT-2 and ATACH-II highlight that early BP control within 2 hours can reduce hematoma growth and improve survival outcomes. 📉 2️⃣ Hemostatic Therapy: • Includes options like rFVIIa and Tranexamic Acid, which showed potential benefits when administered early (under 2.5 hours) as seen in trials like FAST, TICH-2, and ongoing research such as the FASTEST trial. 🩺 3️⃣ Anticoagulation Reversal: • For patients on anticoagulants, rapid reversal is critical. Notable therapies include PCCs for Vitamin K antagonists, Idarucizumab for Direct Thrombin inhibitors, and upcoming options like Andexanet alfa for FXa inhibitors. Studies underscore the importance of achieving INR <1.3 for minimizing hematoma expansion. 🩸 4️⃣ ICP Management & Hematoma Evacuation: • ICP control and selective surgical evacuation are crucial for reducing mass effect and preventing further damage. Procedures like open craniotomy (STICH trials) and minimally invasive surgery (MISTIE-III, ENRICH) show promise for carefully chosen patients. 🧑⚕️ 🌐 Future Directions: • As newer studies emerge, standardized protocols for BP control, hemostatic intervention, and anticoagulation reversal will continue to evolve, with the potential to set new standards in ICH management. 🎖️ This slide by Victor J. Del Brutto, MD, MSc serves as a valuable reminder of the nuanced approach needed to tackle ICH effectively. It’s a testament to the importance of quick, targeted interventions in improving outcomes for these patients. #CriticalCare #StrokeManagement #ICH #MedicalEducation #Neurocriticalcare #SNCC

ICYMI: Cornea Update: Combined Use of Therapeutic Hyper-CL Soft Contact Lens and Insulin Eye Drops for the Treatment of Recalcitrant Neurotrophic Keratopathy: Purpose: The aim of this study was to report the successful clinical outcome of recalcitrant neurotrophic keratopathy (NK) treated with insulin eye drops associated with therapeutic Hyper-CL soft contact lens (CL) (EyeYon Medical, Ness Ziona, Israel). Methods: This study is a case report. Results: A 40-year-old man was referred to our clinic for the management of severe recalcitrant NK developed after surgical and adjuvant radiotherapy treatment of adenoid cystic carcinoma of the nasal cavity with basicranial involvement. The patient presented with severe conjunctival hyperemia, a large (7 × 4 mm) central epithelial defect, corneal opacity and thinning, and deep corneal neovascularization. Unpreserved tear substitutes, vitamin A ointment, punctal plug, bandage CL, and autologous serum had been used for the previous 3 months without success. Patient was prescribed insulin eye drops (1 unit per mL), and therapeutic Hyper-CL soft CL was applied to increase the contact time between insulin eye drops and the corneal surface. Follow-up visits were performed at day 10 (T1) and day 20 (T2). A marked reduction in the epithelial defect size was noted at T1 and complete healing was reached at T2. Simultaneously, conjunctival hyperemia and corneal opacity markedly reduced over time with treatment. Conclusions: The combination of insulin eye drops and therapeutic Hyper-CL soft CL was effective in determining healing of recalcitrant NK not responsive to standard treatments and bandage CL. It is unclear whether the positive outcomes were determined by insulin eye drops, Hyper-CL, or the combination of both, and future randomized clinical trials are warranted to determine the contribution of each treatment. http://dlvr.it/T6CPwr #Cornea #MostPopularArticles #Ophthalmology