es/iode’s Post

📃Scientific paper: Thyroid hormone rewires cortical circuits to coordinate body-wide metabolism and exploratory drive Abstract: Animals adapt to varying environmental conditions by modifying the function of their internal organs, including the brain. To be adaptive, alterations in behavior must be coordinated with the functional state of organs throughout the body. Here we find that thyroid hormone— a prominent regulator of metabolism in many peripheral organs— activates cell-type specific transcriptional programs in anterior regions of cortex of adult mice via direct activation of thyroid hormone receptors. These programs are enriched for axon-guidance genes in glutamatergic projection neurons, synaptic regulators across both astrocytes and neurons, and pro-myelination factors in oligodendrocytes, suggesting widespread remodeling of cortical circuits. Indeed, whole-cell electrophysiology recordings revealed that thyroid hormone induces local transcriptional programs that rewire cortical neural circuits via pre-synaptic mechanisms, resulting in increased excitatory drive with a concomitant sensitization of recruited inhibition. We find that thyroid hormone bidirectionally regulates innate exploratory behaviors and that the transcriptionally mediated circuit changes in anterior cortex causally promote exploratory decision-making. Thus, thyroid hormone acts directly on adult cerebral cortex to coordinate exploratory behaviors with whole-body metabolic state. Continued on ES/IODE ➡️ https://etcse.fr/kDp ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: Thyroid hormone rewires cortical circuits to coordinate body-wide metabolism and exploratory drive Abstract: Animals adapt to varying environmental conditions by modifying the function of their internal organs, including the brain. To be adaptive, alterations in behavior must be coordinated with the functional state of organs throughout the body. Here we find that thyroid hormone— a prominent regulator of metabolism in many peripheral organs— activates cell-type specific transcriptional programs in anterior regions of cortex of adult mice via direct activation of thyroid hormone receptors. These programs are enriched for axon-guidance genes in glutamatergic projection neurons, synaptic regulators across both astrocytes and neurons, and pro-myelination factors in oligodendrocytes, suggesting widespread remodeling of cortical circuits. Indeed, whole-cell electrophysiology recordings revealed that thyroid hormone induces local transcriptional programs that rewire cortical neural circuits via pre-synaptic mechanisms, resulting in increased excitatory drive with a concomitant sensitization of recruited inhibition. We find that thyroid hormone bidirectionally regulates innate exploratory behaviors and that the transcriptionally mediated circuit changes in anterior cortex causally promote exploratory decision-making. Thus, thyroid hormone acts directly on adult cerebral cortex to coordinate exploratory behaviors with whole-body metabolic state. Continued on ES/IODE ➡️ https://etcse.fr/kDp ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

I'm going back to school! After a deliberating for a few years I've decided on a Master's program in Genomic Medicine at St. Georges, University of London. Very excited to dive back into research, expect plenty more science-posting. If you are a scientist on here I encourage you to share articles you find interesting and engage in more open discussion! (do people connect on ScienceDirect/Google Scholar/Sage?) My initial research proposal was taking an Omics approach to characterize the metabolites and proteins present in the decline of neuromelanin containing neurons in Parkinson disease. Other topics I hope to explore literature on or research myself: 1. Neuroendocrine system (relationship to anxiety and depression) 2. Opsins and Cryptochromes (Non-visual photoreceptors) 3. CSF, the Choroid plexus, and Ephaptic communication 4. Glial cell signaling Send me your journal articles! I can't wait to read them :-)

📢 Review paper Sharing-Vol. 29 No. 1 💕 Title: Astrocytes in Spinal Cord Injury: Current Opportunities and Prospects for Directional Polarization 🤵 Authors: Aizilya Bilalova,†, Olga Tutova,†, Yana Mukhamedshina,*, Albert Rizvanov 🔔 Full Text: https://lnkd.in/gvw73gHD 🔑 Keywords: astrocytes; phenotypes; polarization; spinal cord injury 😎Welcome to your reading! #Bioscience #biomedicalscience #biochem #medicalscience #ScienceCommunication #Biochemistry #StemCell #Virology #CancerResearch #immunology #Genetics #MolecularBiology #Microbiology #medicine #health #CellularHealth #CellCancer

Preclinical models are essential research tools before novel therapeutic or diagnostic methods can be applied to humans. These range from in vitro cell monocultures to vastly more complex animal models, but clinical translation to humans often fails to deliver significant results. Three-dimensional (3D) organoid systems are being increasingly studied to establish physiologically relevant in vitro platforms in a trade-off between the complexity of the research question and the complexity of practical experimental setups. The sensitivity and precision of analytical tools are yet another limiting factors in what can be investigated, and mass spectrometry (MS) is one of the most powerful analytical techniques available to the scientific community. Its innovative use to spatially resolve biological samples has opened many research avenues in the field of MS imaging (MSI). Here, this work aims to explore the current scientific landscape in the application of MSI on organoids, with an emphasis on their combined potential to facilitate and improve preclinical studies. Zivko C, Hahm TH, Tressler C, Brown D, Glunde K, Mahairaki V. Mass Spectrometry Imaging of Organoids to Improve Preclinical Research. Adv Healthc Mater. 2024 Jan 21:e2302499. doi: 10.1002/adhm.202302499. Epub ahead of print. PMID: 38247228. #Gesundheit #Bildung #Fuehrung #Coaching #Mindset #Motivation #Gehirn #Neuroscience #Psychologie #Persoenlichkeitsentwicklung #Kindheit #KeyNoteSpeaker #Humangenetik #Biochemie #Neuroleadership #Ernaehrung #Transformation #Stress #Demografie #Gender #Age #interkulturelleKompetenz #Epigenetik #Veraenderung #EmotionaleIntelligenz #Change #Gesellschaft #Organisationsentwicklung #Philosophie #Beratung # Quantum

🔬 Academic Seminar Highlight: Excited to have attended an insightful seminar on "Cardiac Structure and Functional Plasticity: Unveiling New Molecules and Mechanisms" at Shanghai Jiao Tong University's School of Biomedical Engineering. 🗣 Speaker: Dr. Fujian Lu, Researcher 📅 Date & Time: March 14th, 14:00-15:40 📍 Location: Engineering Building 100, Xuhui Campus, Shanghai Jiao Tong University 📝 Abstract: Dr. Lu's presentation delved into the intricate dynamics of excitation-contraction coupling (ECC) in the heart, focusing on the pivotal role of dyads and their protein constituents. Understanding the formation, regulation, and implications of dyad structures is crucial for unraveling novel theories in ECC and calcium signaling, as well as for developing innovative treatments for cardiac diseases. 👨🏫 About the Speaker: Dr. Fujian Lu is a dual-appointed young researcher at Fudan University's Institute of Biomedical Sciences and Zhongshan Hospital. His research interests span spatial-temporal calcium signaling regulation systems, targeted drug development for calcium channelopathies, and gene therapy for cardiac diseases. 📚 Research Highlights: Dr. Lu's research group has made significant contributions to calcium probe development, multi-dimensional calcium imaging, cancer metastasis regulation, ECC regulation, and gene therapy for cardiac diseases, with publications in esteemed journals including Circulation, Nature Communications, and Circulation Research. Kudos to Dr. Lu and his team for their groundbreaking research in advancing our understanding of cardiac physiology and pathology. Looking forward to more enlightening discussions in the future! #biomaterials #regenerativemedicine #genetherapy #biomedicalengineering #biotechnology #MedicalRobotics #AcademicSeminar #HealthTech #shanghai #Innovation #china #c9league

📃Scientific paper: Morphological MRI investigations of the hypothalamus in 232 individuals with Parkinson's disease Abstract: International audience; Background: The pathophysiology of the hypothalamic involvement in Parkinson's disease (PD) is not well understood. The objective of this study was the quantification of hypothalamic volumes in vivo in PD.Methods: High-resolution T1 -weighted magnetic resonance imaging (MRI) data from 232 individuals with PD and 130 healthy non-PD individuals were used for quantification of the hypothalamic volumes.Results: The hypothalamus in PD was not atrophied, as indicated by volumetric analyses in the prospectively collected subcohort (30 PD, V = 921 ± 78 mm3 vs 30 non-PD, V = 917 ± 67 mm3 ; P = 0.850) and validated in a large cohort (202 PD, V = 925 ± 88 mm3 vs 100 non-PD, V = 932 ± 114 mm3 ; P = 0.602). Conclusions: Hypothalamic involvement in PD as shown by a large body of histopathological evidence does not appear to be detectable by MRI-based volumetric quantification. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. Continued on ES/IODE ➡️ https://etcse.fr/uEN ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

🔬 New Insights into the Protein Involved in Sensing Cold ❄ Together with Italian scientists, we identified the structure of the TRPM8 protein, which is involved in detecting cold. Cryo-electron microscopy and artificial intelligence were used in this process. The research could lead to new medical therapies for neuropathic pain and irritable bowel syndrome in the future. Find out more about this exciting discovery 👉 https://lnkd.in/dx3RB5i5 #science #biology #TRPM8 #IIMCB

Adding further insights into the effectiveness of tPBM both in a neuroprotective and neurogenerative aspects.

📃Scientific paper: A qualitative analysis of an Aβ-monomer model with inflammation processes for Alzheimer's disease Abstract: We introduce and study a new model for the progression of Alzheimer's disease incorporating the interactions of Aβ-monomers, oligomers, microglial cells and interleukins with neurons through different mechanisms such as protein polymerization, inflammation processes and neural stress reactions. In order to understand the complete interactions between these elements, we study a spatially-homogeneous simplified model that allows to determine the effect of key parameters such as degradation rates in the asymptotic behavior of the system and the stability of equilibriums. We observe that inflammation appears to be a crucial factor in the initiation and progression of Alzheimer's disease through a phenomenon of hysteresis, which means that there exists a critical threshold of initial concentration of interleukins that determines if the disease persists or not in the long term. These results give perspectives on possible anti-inflammatory treatments that could be applied to mitigate the progression of Alzheimer's disease. We also present numerical simulations that allow to observe the effect of initial inflammation and concentration of monomers in our model. Continued on ES/IODE ➡️ https://etcse.fr/4eCIj ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you. #alzheimer #science #health