The appraisal of #vitaminD status and bioavailability remains a challenge.
TL;DR: Less untargeted screening but MORE targeted screening in at-risk populations 🌞 (see Table 1 in our paper)
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👉Screening for deficiencies or disturbances in vitamin D metabolism should not be performed universally, but in targeted populations.
👉Although not limitative, we propose periodical (e.g., yearly) screening in:
🎯 individuals with osteoporosis or at risk for fragility fractures,
🎯in those on substitution to monitor compliance and adapt dosing, and
🎯in populations at increased risk of vitamin D deficiency such as people with limited sun exposure, patients with intestinal malabsorption, or those using medications affecting vitamin D metabolism.
👉In general, an assessment of vitamin D status by serum 25(OH)D levels can be performed using available immunoassays, keeping their limitations in mind.
👉However, for a more detailed appraisal of vitamin D status, LC-MS/MS is needed, which will also allow for a more profound analysis, e.g., including the VMR.
Comprehensive Ophthalmologist & Glaucoma Specialist at Nova Scotia Health Authority
2moCongrats Andrew well deserved