What are the methods for detecting pyrogens? Several pyrogen detection methods include the RPT (Rabbit Pyrogen Test), MAT (Monocyte Activation Test), and LAL (Limulus Amoebocyte Lysate) assay. The LAL assay has gained widespread acceptance by regulatory bodies such as the FDA and international pharmacopoeias. Among LAL methods, the gel clot method is the most commonly used. This test relies on a coagulation reaction between the endotoxin and the lysate to determine its presence or absence. Read more in our blog: https://loom.ly/D63sI8s #gelclot #gelclotmethod #pyrogentesting #endotoxintesting #LALassay
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Can the Drug Get There? Check out this week’s KASIC pearl to learn the best Antimicrobials in Infected Pancreatic Necrosis ➡ https://lnkd.in/gUKNZaxG #AntimicrobialResistance #antimicrobialstewardship #pharmacy #MedEd #NPs #PAs #infectiousdiseases #antibiotics #antibioticresistance #antibioticstewardship
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✅ Knowledge check 📌 💊💉VANCOMYCIN is a glycopeptide commonly used to treat MRSA. Indications: Vancomycin is a popular glycopeptide that is active against gram-positive bacteria. Vancomycin is commonly used to treat serious or severe Infections when other antibiotics are Ineffective or contraindicated, including those caused by MRSA. 📌 MOA: inhibit bacterial cell wall synthesis 📌Route: IV but PO for C-Diff 📌Side effects: Nephrotoxicity, ototoxicity 📌Poses a significant risk to kidney function #pharmacology #revision #multiplechoice #testprep #notes #pharmacy #pharmacylectures #students #pharmacists #hospitalpharmacists #connect
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Teriparatide Injection First Generic Approval: Quality-Related Review Considerations. Learning Objectives: • Learn quality related recommendations for Teriparatide Injection generic approval • Review examples of common deficiencies to highlight aspects where attention should be focused to facilitate ANDA approval #Teriparatideinjectiongenericapplications #Immunogenicity #Immunogenicityriskmitigation #ANDAapproval #Deficiencies #Q1 #Q2 #Q3 #FDA #FDA505(j) #peptide #syntheticpeptide #Comparabilitystudy #peptideproducts
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Ever wondered how food, gastric pH, or even the rate of gastric emptying can affect drug absorption in the gut? This insightful ASCPT webinar breaks down the complexities, highlighting when a pilot food effect study is essential and how new FDA guidelines are shaping studies involving acid-reducing agents. Plus, dive into the effects of GLP-1 receptor agonists, widely used in weight loss and diabetes treatment, on drug pharmacokinetics. Watch now to gain a deeper understanding of these critical factors in drug absorption: https://lnkd.in/eW8Rysdb #DrugAbsorption #ClinicalResearch #GLP1Agonists #Pharmacokinetics #DrugDevelopment #Bioavailability
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Cholesterol-lowering #statins already improve the lives of millions of people worldwide – and they could soon be helping fight gum disease, too.💡 > Researchers at the Medical University of South Carolina have built upon previous studies suggesting that people who take statins tend to show fewer signs of gum infection, or periodontitis. > They discovered that the common statin drug simvastatin suppressed the inflammatory response generated by macrophages – a type of white blood cell key to the body’s immune system. > If further studies using statins on animals with gum disease prove successful, the treatment could potentially become a safe new way to combat periodontitis in humans. 🔬 LGC Standards supports statins research and analysis with 100+ TRC #ResearchChemicals and 60+ high quality #pharmaceutical #ReferenceMaterials from Mikromol: https://okt.to/OysE2B #ScienceForASaferWorld
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Did you know deutetrabenazine (Austedo) used for tardive dyskinesia and Huntington disease-associated chorea has PGx guided dosing? From the drug label: "In patients who are poor CYP2D6 metabolizers, the total daily dosage of AUSTEDO should not exceed 36 mg (maximum single dose of 18 mg)." The same max dose recommendations hold true if your patient is taking deutetrabenazine with strong CYP2D6 inhibitors such as paroxetine, fluoxetine, and bupropion. #pharmacogenomics #pharmacist
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Cholesterol-lowering #statins already improve the lives of millions of people worldwide – and they could soon be helping fight gum disease, too.💡 > Researchers at the Medical University of South Carolina have built upon previous studies suggesting that people who take statins tend to show fewer signs of gum infection, or periodontitis. > They discovered that the common statin drug simvastatin suppressed the inflammatory response generated by macrophages – a type of white blood cell key to the body’s immune system. > If further studies using statins on animals with gum disease prove successful, the treatment could potentially become a safe new way to combat periodontitis in humans. 🔬 LGC Standards supports statins research and analysis with 100+ TRC #ResearchChemicals and 60+ high quality #pharmaceutical #ReferenceMaterials from Mikromol: https://okt.to/47Wgyu #ScienceForASaferWorld
Study suggests statins could help fight gum disease
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💡 Researchers at the Medical University of South Carolina have built upon previous studies suggesting that people who take #statins tend to show fewer signs of gum infection, or periodontitis. > They have found that the common cholesterol-lowering drug, simvastatin, suppresses the inflammatory response generated by macrophages- a type of white blood cell key to the body’s immune system. > If further studies using statins on animals with gum disease prove successful, it could lead to a safe new way to fight periodontitis in humans. 🔬 In support of statins research and analysis, LGC Standards offers 100+ TRC #ResearchChemicals and 60+ high-quality #pharmaceutical #ReferenceMaterials from Mikromol. You can find them at https://okt.to/2W43Jz #ScienceForASaferWorld
Study suggests statins could help fight gum disease
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Cholesterol-lowering #statins already improve the lives of millions of people worldwide – and they could soon be helping fight gum disease, too.💡 > Researchers at the Medical University of South Carolina have built upon previous studies suggesting that people who take statins tend to show fewer signs of gum infection, or periodontitis. > They discovered that the common statin drug simvastatin suppressed the inflammatory response generated by macrophages – a type of white blood cell key to the body’s immune system. > If further studies using statins on animals with gum disease prove successful, the treatment could potentially become a safe new way to combat periodontitis in humans. 🔬 LGC Standards supports statins research and analysis with 100+ TRC #ResearchChemicals and 60+ high quality #pharmaceutical #ReferenceMaterials from Mikromol: https://okt.to/dHFORG #ScienceForASaferWorld
Study suggests statins could help fight gum disease
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Cholesterol-lowering #statins already improve the lives of millions of people worldwide – and they could soon be helping fight gum disease, too.💡 > Researchers at the Medical University of South Carolina have built upon previous studies suggesting that people who take statins tend to show fewer signs of gum infection, or periodontitis. > They discovered that the common statin drug simvastatin suppressed the inflammatory response generated by macrophages – a type of white blood cell key to the body’s immune system. > If further studies using statins on animals with gum disease prove successful, the treatment could potentially become a safe new way to combat periodontitis in humans. 🔬 LGC Standards supports statins research and analysis with 100+ TRC #ResearchChemicals and 60+ high quality #pharmaceutical #ReferenceMaterials from Mikromol: https://okt.to/wei9CR #ScienceForASaferWorld
Study suggests statins could help fight gum disease
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