FUJIFILM Wako Pyrostar’s Post

Can the Drug Get There? Check out this week’s KASIC pearl to learn the best Antimicrobials in Infected Pancreatic Necrosis ➡ https://lnkd.in/gUKNZaxG #AntimicrobialResistance #antimicrobialstewardship #pharmacy #MedEd #NPs #PAs #infectiousdiseases #antibiotics #antibioticresistance #antibioticstewardship

Did you know deutetrabenazine (Austedo) used for tardive dyskinesia and Huntington disease-associated chorea has PGx guided dosing? From the drug label: "In patients who are poor CYP2D6 metabolizers, the total daily dosage of AUSTEDO should not exceed 36 mg (maximum single dose of 18 mg)." The same max dose recommendations hold true if your patient is taking deutetrabenazine with strong CYP2D6 inhibitors such as paroxetine, fluoxetine, and bupropion. #pharmacogenomics #pharmacist

✅ Knowledge check 📌 💊💉VANCOMYCIN is a glycopeptide commonly used to treat MRSA. Indications: Vancomycin is a popular glycopeptide that is active against gram-positive bacteria. Vancomycin is commonly used to treat serious or severe Infections when other antibiotics are Ineffective or contraindicated, including those caused by MRSA. 📌 MOA: inhibit bacterial cell wall synthesis 📌Route: IV but PO for C-Diff 📌Side effects: Nephrotoxicity, ototoxicity 📌Poses a significant risk to kidney function #pharmacology #revision #multiplechoice #testprep #notes #pharmacy #pharmacylectures #students #pharmacists #hospitalpharmacists #connect

Teriparatide Injection First Generic Approval: Quality-Related Review Considerations. Learning Objectives: • Learn quality related recommendations for Teriparatide Injection generic approval • Review examples of common deficiencies to highlight aspects where attention should be focused to facilitate ANDA approval #Teriparatideinjectiongenericapplications #Immunogenicity #Immunogenicityriskmitigation #ANDAapproval #Deficiencies #Q1 #Q2 #Q3 #FDA #FDA505(j) #peptide #syntheticpeptide #Comparabilitystudy #peptideproducts

Ever wondered how food, gastric pH, or even the rate of gastric emptying can affect drug absorption in the gut? This insightful ASCPT webinar breaks down the complexities, highlighting when a pilot food effect study is essential and how new FDA guidelines are shaping studies involving acid-reducing agents. Plus, dive into the effects of GLP-1 receptor agonists, widely used in weight loss and diabetes treatment, on drug pharmacokinetics. Watch now to gain a deeper understanding of these critical factors in drug absorption: https://lnkd.in/eW8Rysdb #DrugAbsorption #ClinicalResearch #GLP1Agonists #Pharmacokinetics #DrugDevelopment #Bioavailability

Cholesterol-lowering #statins already improve the lives of millions of people worldwide – and they could soon be helping fight gum disease, too.💡 > Researchers at the Medical University of South Carolina have built upon previous studies suggesting that people who take statins tend to show fewer signs of gum infection, or periodontitis. > They discovered that the common statin drug simvastatin suppressed the inflammatory response generated by macrophages – a type of white blood cell key to the body’s immune system. > If further studies using statins on animals with gum disease prove successful, the treatment could potentially become a safe new way to combat periodontitis in humans. 🔬 LGC Standards supports statins research and analysis with 100+ TRC #ResearchChemicals and 60+ high quality #pharmaceutical #ReferenceMaterials from Mikromol: https://okt.to/47Wgyu #ScienceForASaferWorld

Cholesterol-lowering #statins already improve the lives of millions of people worldwide – and they could soon be helping fight gum disease, too.💡 > Researchers at the Medical University of South Carolina have built upon previous studies suggesting that people who take statins tend to show fewer signs of gum infection, or periodontitis. > They discovered that the common statin drug simvastatin suppressed the inflammatory response generated by macrophages – a type of white blood cell key to the body’s immune system. > If further studies using statins on animals with gum disease prove successful, the treatment could potentially become a safe new way to combat periodontitis in humans. 🔬 LGC Standards supports statins research and analysis with 100+ TRC #ResearchChemicals and 60+ high quality #pharmaceutical #ReferenceMaterials from Mikromol: https://okt.to/wei9CR #ScienceForASaferWorld

Daily Critical Care Pearls #153: Antimicrobial Adjustments in CRRT 💉The most common of CRRT is continuous veno-venous hemodiafiltration (CVVHDF) in which both diffusion and convection are used. This results in greater drug removal than either method by itself. 💉Rates of 3 or more liters per hour, especially if the antibiotic has low protein binding, low molecular size, and low Vd will require further adjustment or alternative antibiotics 💉Antimicrobials that get dose increases: Fluconazole, Meropenem, Piperacillin/Tazobactam 💉Antimicrobials that get dose reductions: Acyclovir, Amikacin, Amphotericin B deoxycholate, Ganciclovir, Gentamicin, Tobramycin, Trimethoprim-sulfamethoxazole, Vancomycin, Voriconazole. #criticalcare #pharmacy #medicine #clinicalpharmacy #pearls

𝐏𝐓𝐂 𝐓𝐡𝐞𝐫𝐚𝐩𝐞𝐮𝐭𝐢𝐜𝐬 𝐀𝐧𝐧𝐨𝐮𝐧𝐜𝐞𝐬 𝐅𝐃𝐀 𝐓𝐚𝐫𝐠𝐞𝐭 𝐃𝐚𝐭𝐞 𝐟𝐨𝐫 𝐒𝐞𝐩𝐢𝐚𝐩𝐭𝐞𝐫𝐢𝐧 𝐍𝐃𝐀 𝐚𝐧𝐝 𝐏𝐡𝐚𝐬𝐞 𝟑 𝐑𝐞𝐬𝐮𝐥𝐭𝐬 𝐢𝐧 𝐓𝐡𝐞 𝐋𝐚𝐧𝐜𝐞𝐭 PTC Therapeutics (NASDAQ: PTCT) PTC Therapeutics, Inc. announced the FDA has set a regulatory action date of July 29, 2025, for the review of its New Drug Application (NDA) for sepiapterin, aimed at treating phenylketonuria (PKU) across all age groups and disease subtypes. The NDA submission includes data from the Phase 3 APHENITY trial, recently published in The Lancet. The study showed that 60% of patients achieved protein intake above age-adjusted recommendations while maintaining phenylalanine (Phe) levels < 360 μmol/L, demonstrating the potential for improved dietary flexibility. Sepiapterin works through a dual mechanism: it converts to tetrahydrobiopterin (BH4) to enhance enzyme function and acts as a pharmacological chaperone to correct PAH enzyme misfolding. #Biopharma #RareDisease #PKUAwareness #MetabolicDisorders #GeneTherapy #ClinicalResearch #FDAApproval #PTCTherapeutics #TheLancet

Daily Critical Care Pearls #157: ECMO Pharmacotherapy - Part 2 (Antibiotics) 📌 Beta-lactams: Dose based on physiochemical properties (Consider 2g Ceftriaxone instead of 1, Meropenem / Piperacillin-Tazobactam unaffected, Ampicillin is removed - choose another agent) 📌 Vancomycin: ECMO does not significantly influence vancomycin ➡️ Dose as per usual in critical illness 📌  Aminoglycosides: Expect large increase in Vd ➡️ Use higher end of normal loading dose if considering a range and use therapeutic drug monitoring. #criticalcare #pharmacy #medicine #clinicalpharmacy #pearls