Giulia Frumento, Ph.D.’s Post

Hence screening for Lp(a), at least once, is supremely important. 💥 Novel therapeutics are “akan datang” (“coming soon” in the local vernacular). But in the meantime, there’re strategies we employ to reduce overall cardiovascular risks in individuals with elevated Lp(a). For some of them, I also offer PCSK9 inhibitors. Go speak to your friendly neighborhood cardiologist if you’re keen for a check! We don’t bite. 😉 #preventivecardio #lp(a) #PCSK9i

Non-Invasive Early Warning System of Systemic Hypoperfusion: Circulatory Shock and Sepsis - Part I: The Problem   by Michael R. Pinsky, MD and Jacques Creteur, MD   The Problem:  Circulatory shock is defined as an inadequate oxygen (O2) delivery to tissue to sustain metabolic demand. If arterial oxygen content is adequate, then tissue ischemia develops only at the very extremes of low blood flow. Well before that time, normal physiologic adaptive mechanisms controlled by the autonomic nervous system and mediated primarily through increased sympathetic tone tend to sustain an adequate central arterial blood pressure despite falling total blood flow. Once this regulatory process is exhausted, however, systemic hypotension develops. Thus, systemic hypotension, defined as a mean arterial pressure <65 mmHg or a systolic arterial pressure <90 mmHg, occurs late in shock when tissue hypoperfusion is already compromising metabolic function. If circulatory shock associated with systemic hypotension persists, then generalized tissue ischemia manifests as end-organ failure, lactic acidosis and autonomic failure. If the bedside clinician waits for systemic hypotension to recognize circulatory insufficiency before treating their patient for circulatory shock, then he will have waited too long. #shock #hypoperfusion #sepsis #circulation

🔍 New Insight 🔍 Could insulin resistance (IR) be a hidden contributor to varicose vein disease❓ This review explores the shared mechanisms—mitochondrial dysfunction, inflammation, endothelial dysfunction, and tissue hypertrophy—linking IR to varicose veins. With IR prevalence on the rise, uncovering its role could reshape our understanding of vascular health. 📌Don’t miss this critical read—download now! ⬇️ https://lnkd.in/gEXEWuVZ #VascularHealth #InsulinResistance #VaricoseVeins #EndothelialDysfunction #CardiometabolicResearch Dr. Ashish Dhadas Dr Pierre Sarradon Vinay Madan, MD, DABVLM Dr Ashok Reddy Somu John A. Babalola, MD,MSc,MPH,FACS Dr. Pradyumna Reddy NavYash Gupta Dr Lijo Eliyas Ahmed Gaweesh

Acute appendicitis on CT. https://lnkd.in/g4fi9jE8 Typically presents with an enlarged appendix (>6 mm diameter), wall thickening, and peri-appendiceal fat stranding due to inflammation. Additional findings may include an appendicolith, fluid collection, or abscess formation in complicated cases.

This opinion article provides up-to-date guideline recommendations for patients presenting with acute ischemic stroke in the setting of HFrEF. #Heartfailure #Stroke https://lnkd.in/exf7Ap8j

Purple Urine Bag Syndrome. https://lnkd.in/gMm8PTUD Purple urine bag syndrome (PUBS) is a rare but important phenomenon that can occur in patients with long-term indwelling urinary catheters. It is characterized by the development of a purple discoloration in the urine bag, caused by the production of indigo and indirubin pigments by certain bacteria in UTI.

PNH : why venous thrombosis is much more common than arterial thrombosis in PNH patients? The hemolysis in PNH releases free hemoglobin and other factors that promote a hypercoagulable state: to form blood clots. These effects more significantly impact the venous system rather than arterial system. ✅Because of 2 key 🔑 reasons : ✅A. The chronic complement activation and inflammation in PNH predominantly affect the endothelium of veins. This endothelial damage promotes venous clot formation rather than arterial thrombosis. ✅B. Venous blood flow is slower compared to arterial flow. Slower blood flow in veins provides more opportunity for clot formation. Would discuss the other key 🔑 aspects in InstaLecture in coming days. #pathology360 #DrKishoreBanerjee

💡 The main cause of coronary artery disease (CAD) is the buildup of plaque in the walls of the coronary arteries, which supply blood to the heart. This plaque is made up of cholesterol, fatty substances, cellular waste products, calcium, and fibrin. Over time, this buildup narrows the arteries, reducing blood flow to the heart, and can lead to chest pain (angina), heart attacks, or other complications. ☄️ #CardiologyAssociates #Morristown #HeartHealth #HealthyHeart #ComprehensiveCardiovascularCare #Cardiologists #CardiovascularHealth #CoronaryArteryDisease #CAD

Fibroblast cells play a key role in resolving joint inflammation, new study finds https://lnkd.in/deZXsdMP

Scleroderma skin findings in pts w/ skin of colour (SOC) - Raynauds was common but SOC pts had fewer hallmark Sxs: telangiectasias, calcinosis, digital swelling (complicating Dx). SOC had more severe pulmonary Dz & increased mortality, Atypical skin findings https://buff.ly/4g3rhg4