Grenoble Institut Neurosciences’ Post

Emmanuel Barbier (Grenoble Institut Neurosciences) spoke at the Bruker Scientific Workshop at ISMRM in Singapore. Watch his talk entitled "MR in Several Epilepsy Models" here: https://lnkd.in/eJb2-RuH Dr. Barbier and his team have been focusing their work on epilepsy, using two different models. In the first model, a mesial temporal lobe epilepsy (MTLE) mouse model, they evaluated the benefits of multiparametric quantitative #MRI, including both structural and perfusion data, and the benefits of GABA-edited spectroscopy, using first a single voxel, MEGA-PRESS, approach and then using spectroscopic imaging tools developed in-house. These two approaches, which could be combined, could help delimit the epileptogenic area and thus improve the outcome of brain surgery in epileptic patients. The second model is a rat epilepsy-absence model, in which they evaluated the benefit of conducting fMRI in awake animals, using a more silent, zero-echo time approach. Thereby, they could compare the brain response to visual stimuli during ictal and inter-ictal states. Altogether, preclinical MR appears as a powerful tool for characterizing the epileptogenic zone and for understanding how an epileptic seizure perturbs brain functions. #ISMRM2024 #Imaging #PreclinicalImaging #Neurosciences