HAYA Therapeutics’ Post

Recent study published in Nature Communications on the structural basis of CCR6 modulation by allosteric antagonists. The research reveals detailed insights into how small molecule antagonists, like OXM1 and OXM2, interact with CCR6 to disrupt its activation, offering new perspectives on targeting this receptor for chronic inflammatory diseases. The findings highlight the versatility of GPCR antagonism, providing valuable knowledge that could advance drug discovery efforts focused on CCR6. Exciting developments in the field of structural biology and drug design! #StructuralBiology #DrugDiscovery #GPCR #InflammationResearch https://lnkd.in/g5Xaqj3R

Our #DigitalProteome™ platform was showcased on a poster at #HUPO2024 and is now available for download. 🌟 This qualitative and quantitative proteome library offers unparalleled insights into tissue biology, enabling the exploration of diverse proteoforms across various tissue types, such as protein isoforms and non-canonical translation products. 📊 Highlights include: ➡️ Extensive quantitative proteome map across 22 human tissues, 23 mouse tissues, and 24 rat tissues. ➡️ In-depth tissue-specific protein expression levels, with proof-of-concept examples on CDK proteins and E3 ligases. ➡️ Supports in silico pharmacological assessments, revealing potential drug targets and off-targets. 📥 Download the poster and see how DigitalProteome™ can accelerate your clinical & pre-clinical research: https://lnkd.in/djX8a6fF #Proteomics #BiomarkerDiscovery #DrugDevelopment

🔬 𝗡𝗲𝘄 𝗧𝟭 𝗮𝗻𝗱 𝗧𝟮 𝗗𝗶𝗮𝗯𝗲𝘁𝗲𝘀 𝗜𝗻𝗳𝗹𝗮𝗺𝗺𝗮𝘁𝗶𝗼𝗻 𝗔𝘀𝘀𝗮𝘆 🔬 𝗥𝗲𝘃𝗲𝗮𝗹 𝘆𝗼𝘂𝗿 𝗱𝗿𝘂𝗴’𝘀 𝗮𝗻𝘁𝗶-𝗶𝗻𝗳𝗹𝗮𝗺𝗺𝗮𝘁𝗼𝗿𝘆 𝗽𝗼𝘁𝗲𝗻𝘁𝗶𝗮𝗹 𝘄𝗶𝘁𝗵 𝗮 𝗵𝘂𝗺𝗮𝗻 𝗽𝗮𝘁𝗵𝗼𝗹𝗼𝗴𝗶𝗰𝗮𝗹𝗹𝘆 𝗿𝗲𝗹𝗲𝘃𝗮𝗻𝘁 𝗧𝘆𝗽𝗲 𝟭 𝗮𝗻𝗱 𝗧𝘆𝗽𝗲 𝟮 𝗱𝗶𝗮𝗯𝗲𝘁𝗲𝘀-𝗺𝗲𝗱𝗶𝗮𝘁𝗲𝗱 𝗶𝗻𝗳𝗹𝗮𝗺𝗺𝗮𝘁𝗶𝗼𝗻 𝗮𝘀𝘀𝗮𝘆! Using Endoc-BH5® cells, our latest innovative assay 𝗿𝗲𝗽𝗿𝗼𝗱𝘂𝗰𝗲𝘀 𝗶𝗻 𝘃𝗶𝘁𝗿𝗼 𝘁𝗵𝗲 𝗰𝗹𝗶𝗻𝗶𝗰𝗮𝗹𝗹𝘆 𝗼𝗯𝘀𝗲𝗿𝘃𝗲𝗱 𝗿𝗲𝘀𝗽𝗼𝗻𝘀𝗲 𝗼𝗳 𝗵𝘂𝗺𝗮𝗻 𝗽𝗮𝗻𝗰𝗿𝗲𝗮𝘁𝗶𝗰 𝗯𝗲𝘁𝗮 𝗰𝗲𝗹𝗹𝘀 𝘁𝗼 𝗰𝘆𝘁𝗼𝗸𝗶𝗻𝗲-𝗶𝗻𝗱𝘂𝗰𝗲𝗱 𝗶𝗻𝗳𝗹𝗮𝗺𝗺𝗮𝘁𝗶𝗼𝗻 𝗽𝗿𝗼𝗰𝗲𝘀𝘀 observed in Type 1 and Type 2 diabetes. 𝗟𝗲𝗮𝗿𝗻 𝗺𝗼𝗿𝗲 𝗮𝗯𝗼𝘂𝘁 𝘁𝗵𝗲 𝗮𝘀𝘀𝗮𝘆: https://lnkd.in/ebTxcKke 𝗖𝗼𝗻𝘁𝗮𝗰𝘁 𝘂𝘀: contact@humancelldesign.com #Assay #DiabetesResearch #Type1Diabetes #Type2Diabetes #EndoCBH5 #BetaCell #Pancreas # #CellModel #InVitro #Research #Diabetes #ResearchModel #Research #TranslationalResearch #Innovation #Biotechnology #DrugDevelopment #Technology #MedicalResearch #Biomedical #Bioengineering #Science #HumanCellDesign

Non-natural nucleic acids (#XNA) are garnering significant attention from both academia and the pharmaceutical industry. Their therapeutic promises are strong. But how can #computational #chemistry assist in investigating these fascinating molecules? High-Performance Computing is essential in advancing this process. Where do we stand? What are we doing? What are the major challenges in the field? To explore further, we have provided a snapshot of the current landscape. Our contribution has been published in Current Opinion in Structural Biology (#COSB). A small spoiler: we are just at the beginning of this promising and exciting journey.

ApoE3 enhances uptake and delivery of #LNPs due to binding of LDLR (low-density lipoprotein receptor) on target cells. Additionally, ApoE3 improves intracellular #delivery of LNPs by assisting in endosomal escape.

We are thrilled to share our latest review titled "Nucleic Acids in Modern Molecular Therapies: A Realm of Opportunities for Strategic Drug Design," co-authored by Vito Genna, Director of Nucleic Acids, Javier Iglesias Fernández, Director of R&D, and Nostrum Co-Founder Prof. Modesto Orozco. This comprehensive essay delves into innovative approaches to drug discovery, highlighting the revolutionary potential of nucleic acids in modern molecular treatments. A must-read for anyone passionate about the latest advancements in therapeutic science! ⬇️ A piece of the review ⬇️ "RNA vaccines have made evident to society what was already known by the scientific community: nucleic acids will be the “drugs of the future.” By modifying the genome, interfering in transcription or translation, and by introducing new catalysts into the cell or by mimicking antibody effects, nucleic acids can generate therapeutic activities that are not accessible by any other therapeutic agents. There are, however, challenges that need to be solved in the next few years to make nucleic acids usable in a wide range of therapeutic scenarios. This review illustrates how simulation methods can help achieve this goal." #NucleicAcids #MolecularTherapies #DrugDesign

We are thrilled to introduce “Liquid-liquid phase separation in cells” – a Dewpoint-sponsored 𝘕𝘢𝘵𝘶𝘳𝘦 𝘊𝘰𝘭𝘭𝘦𝘤𝘵𝘪𝘰𝘯, which compiles prominent papers in the field of biomolecular #condensate science. The collection of articles, independently selected by the editorial staff at Nature Portfolio, includes reviews and original research articles that discuss: 🔬 The role of biomolecular condensates as hubs for splicing regulation and protein aggregation 🗺 Mapping the composition of endogenous biomolecular condensates  ⚙ Molecular mechanisms by which cancer-driving proteins restructure chromatin to promote uncontrolled cell proliferation For a limited time, the publications included in the editorial collection are freely accessible to all. https://lnkd.in/gv6crsZD  

Fresh off the press, first paper from PhD student, Jono Caukwell in JCIS. In this study we investigated behaviour of lipid nanoparticles after exposure to representative bacterial strains found in the gastrointestinal tract and skin. SAXS and PLM revealed that monoolein cubic and inverse hexagonal phases transformed into inverse hexagonal and inverse micellar cubic phases upon exposure to live Staphylococcus aureus. Enzymatic hydrolysis and cell membrane lipid transfer contribute to this effect, which significantly reduces drug release rates. These findings highlight how the human microbiome can impact lipidic nanomaterials’ structure and drug release properties, with strain-specific variations across patients and body regions. Thanks to co-authors: Livia Salvati Manni Karl Hassan Andrew Clulow Brett Neilan Salvatore Assenza https://lnkd.in/dsqKTekA

🔬 Transform Your Research with Tailored Drug Libraries! Are you investigating intracellular pathways, targeting specific protein classes, or exploring mechanisms like autophagy, DNA repair, or apoptosis? Targeted chemical compound libraries are versatile tools that can serve two key purposes: 1️⃣ A Functional Research Tool: Comparable to siRNAs or CRISPR-Cas, these libraries enable precise interrogation of intracellular pathways and molecular mechanisms. 2️⃣ Therapeutic Discovery Opportunities: These libraries provide a foundation for identifying compounds with the potential to become future therapies. HTB is expanding its collections to better serve the scientific community, and we want to hear from you! 🧪 💡 Which of these would advance your research? •Antiviral compounds •GPCRs •DNA Repair •Kinase Inhibitors •Autophagy and Apoptosis •Lipid Metabolism Or is there another library you need? Your feedback helps us tailor our collections to support both functional research and therapeutic innovation. 👉 Vote now and share your input: https://lnkd.in/dCziApdr #FunctionalScreening, #TargetedDrugLibraries, #PathwaySpecificInhibitors

🧬 mRNA Splicing: The Molecular Magic Behind Life's Instructions! ✂️ mRNA splicing is like editing a rough draft of a book, removing the unnecessary parts (introns), and stitching together the essential ones (exons) to create a final masterpiece. 📖 Why do you think understanding mRNA splicing is so crucial in biotechnology and medicine? Share your thoughts below! 👇