HE - RATION’s Post

🚨✍️In the latest publication 📰 by Fischer et al. from the German Federal Institute for Risk Assessment (BfR), the Department of Pesticides Safety highlighted that the (Q)SAR works well for predicting bacterial mutagenicity of pesticides and their metabolites, but predictions for clastogenicity in vitro can be improved further. 👉 The publication emphasizes the critical role of the genotoxicity assessment in ensuring the safety of pesticides and biocides, highlighting the traditional in vitro tests and the emerging reliability of (Q)SAR models. 👉 The study evaluates the performance of various commercial and freely available expert and statistical (Q)SAR models for bacterial mutagenicity (Derek Nexus and ISS) and chromosome damage (IRFMN/VERMEER and CORAL) using curated test sets from regulatory submissions for biocides and plant protection products. 👉 It was noted that the use of a combination of different in silico models improved the prediction accuracy for bacterial mutagenicity and chromosome damage. 👉 Derek + KNN showed the best performance for mutagenicity, while Derek combined with IRFMN/VERMEER and Coral enhanced sensitivity for chromosome damage. 👉The study finally concludes that in silico models, especially when used in combinations, are promising for genotoxicity assessment, potentially replacing or supplementing traditional tests. Continuous improvement and regulatory integration of these models could streamline the genotoxicity assessment process for pesticides and biocides. https://lnkd.in/g9RfCHtE #insilico #QSAR #mutagenicity #clastogenicity #pesticides #chromosomaldamage #NAMs

🌟 New Publication! 🌟 I'm very pleased to announce my study on the impact of the organophosphorus pesticide Dimethoate on the Mediterranean green crab, Carcinus aestuarii. 🦀 This research has been published in #PesticideBiochemistryandPhysiology with Elsevier 🔍Why It Matters ? Fatty acids play a crucial role in cellular health and function, and their composition in animal tissues can serve as a valuable indicator of the toxic effects of environmental contaminants. In our study, we examined how this pesticide influences the lipid profile of crab muscles, thereby providing insights into its potential toxicity. 📊 Key Findings: Impact on Fatty Acids: Significant changes in lipid profiles are linked to pesticide exposure. Toxicity Indicator: Fatty acid composition as a sensitive marker for environmental toxicity. 🔬 Our research also covers changes in redox status and histopathological damage; still, the variations in fatty acids are particularly striking as early markers of toxicity. 📝 The full text is available upon request. Please get in touch if you are interested 🔗https://lnkd.in/dJC2984d #Research #Toxicology #EnvironmentalScience #FattyAcids #Pesticides #MarineHealth

And following on from this, the Institute of Professional Representatives before the European Patent Office (epi, the body for European patent attorneys) have issued a position paper on the proposal to ban patents for plants obtained by NGTs. I think it can be summarised in the words of Olivia Rodrigo as "bad idea right?" https://lnkd.in/esXZg_w7 #patents #agritech #genomeediting #oliviarodrigo

New Fees Introduced by the National Biosafety Authority Starting October 1, 2024, the National Biosafety Authority will implement new fees for services related to GMOs, including applications, inspections, labelling, and genetic editing consultations. Key charges include: — Annual GMO permit: Sh1,000 — GMO-Free Certificates: Sh5,500 per shipment — Disagreement Letters: Sh5,500 per shipment — Review of confidential application info: Sh20,000 For Institutional Biosafety Committees: — Registration fee: Sh20,000 — Annual renewal: Sh10,000 — Biosafety training: Sh100,000 #Biosafety #GMO #Kenya #Regulation #Biotechnology

🖨️ New publication on CUMULATIVE RISK ASSESSMENT OF PESTICIDES. This report provides a comprehensive hazard characterization of pesticide substances affecting thyroid function, contributing to cumulative risk assessment update for effects on the thyroid.

USDA Final Genetically Modified Organism (GMO) Label Rule Speaker - Dr. John Ryan Duration - 60 Minutes in Purchase https://lnkd.in/gUX2isec In order to provide consumers with trust in labeling, transparency, education, and other factors, If your product contains greater than 5% of ingredients that were bioengineered, product labeling must contain the appropriate mandatory labeling. This webinar will provide you and your staff with disclosure methods, implementation deadlines, labels, printed text, scanning information, web address, and text messaging designed to be sent directly to consumer mobile devices that disclose product GMO information. Food manufacturers are required to “prominently’ display clear label information regarding the presence of bioengineered ingredients. The new rules are designed to provide consumers with clear information and consistently labeled products. Understanding how the GMO Label Rules apply to your products is critical in order to avoid recalls. #GMOlabelrule #GMO #USDA #finalgenetically #drjohnryan #Foodwebinar #Beverageswebinar #conferencepanel #healthcarewebinars #foodmanufacturer

USDA Final Genetically Modified Organism (GMO) Label Rule Speaker - Dr. John Ryan Duration - 60 Minutes in Purchase https://lnkd.in/gUX2isec In order to provide consumers with trust in labeling, transparency, education, and other factors, If your product contains greater than 5% of ingredients that were bioengineered, product labeling must contain the appropriate mandatory labeling. This webinar will provide you and your staff with disclosure methods, implementation deadlines, labels, printed text, scanning information, web address, and text messaging designed to be sent directly to consumer mobile devices that disclose product GMO information. Food manufacturers are required to “prominently’ display clear label information regarding the presence of bioengineered ingredients. The new rules are designed to provide consumers with clear information and consistently labeled products. Understanding how the GMO Label Rules apply to your products is critical in order to avoid recalls. #GMOlabelrule #GMO #USDA #finalgenetically #drjohnryan #Foodwebinar #Beverageswebinar #conferencepanel #healthcarewebinars #foodmanufacturer

#SETACSeville is underway! The sessions this year look excellent, and we’re excited to be able to contribute to some of them with several talks, poster spotlight and posters, which we would love to see you at: 📅Monday 6th May  📊Poster no. 242 A Workshop Discussion on Options for Mitigation of Drain Flow and Groundwater Contamination by Pesticides – Charles Hazlerigg  📊Poster no. 252 Acre Tool for Automated Surface Water Modelling – Alice Tagliati  📍Both in Session 3.15 Measuring and Modelling the Environmental Fate and Exposure of Pesticides 📅Tuesday 7th May  🗣15:00 How to Effectively Assess the Endocrine Disruption Potential of Metals Under the EU CLP Regulation – Chloe Eastabrook 🗣15:30 Population Relevance of Endocrine-Mediated Effects of Pesticide and Biocide Substances – A Way Forward – Alice Tagliati  📍Auditorium 3, in Session 1.13 The Endocrine Disrupting Properties of Challenging Substances: How to Solve Testing and Interpretation Issues? 📊🗣Poster spotlight no. 003 Is Disrupted Reproductive Behaviour Population-Relevant? – Charles Hazlerigg  📍Session 1.04 Behavioural Toxicology: Methodologies and Research Needs 📊Poster no. 423 Bat Activity in Arable Farmland: Assessing Potential Risks from Plant Protection Products – Charles Hazlerigg  📍Session 4.11 Protecting Innovation in Plant Protection: Low-risk Pesticides, Precision Applications, and Considerations on Risk Assessment We hope to see you in Seville at one of our sessions or head to our stand (220) to say hello. #RegulatoryEcotox #pesticides #ED #populationmodelling #metals

The EU parliament has greenlit the EU Commission’s proposal concerning new regulations for plants derived from ‘New Genomic Techniques’ (NGTs), albeit with a notable amendment to prohibit patent protection for these plants. Under the approved proposal, NGT plants will be divided into two categories, each with its own set of regulations. Category 1 NGT plants (NGT-1) will be treated similarly to “conventional plants” and subject to less stringent regulations whereas Category 2 NGT plants (NGT-2) will need to adhere to existing GMO legislation. The article from Georgia Rundle explores the factors behind the proposal, outlines its specifics and the reactions it has elicited. Click here to read more: https://lnkd.in/ehj7eX34 #EURegulations #GMO #PlantInnovation #Patent 

Hold on to your hats! Last week, the European Parliament made a groundbreaking decision by voting in favour of a proposal to ban the patenting of new genomic techniques (NGT) for plants, plant material, parts thereof, genetic information, and the process features they contain. This proposal can potentially change the fate of plant-based innovations utilizing gene editing and other established genomic techniques, including CRISPR/Cas. To get all the juicy details, check out the article by my colleague Georgia Rundle from Marks & Clerk!! #euregulation #patents #plantscience #gmo #marksandclerk