Hemant Shah’s Post

Molecule of the year -3 (2024) One hundred years ago, Julius Bredt's observation that certain molecules couldn't form double bonds between adjacent carbon centers, known as "anti-Bredt" olefins, but now has been challenged by McDermott et al., who report a strategy to prepare these olefins as fleeting intermediates for cycloaddition reactions. Rule-bending strained alkene A solution to the anti-Bredt olefin synthesis problem Bridged organic molecules with a double bond at the bridgehead position (shown here as two lines in red) have been regarded for 100 years as too strained to make, but that hasn't stopped chemists from trying. This year, they finally succeeded (Science 2024, DOI: 10.1126/science.adq3519). The structures are too unstable to isolate, but the researchers used them as intermediates in cycloaddition reactions to create complex 3D structures. For more information: https://lnkd.in/dSxyqVtC

Breaking a Century-Old Rule: Chemists Achieve the 'Impossible' with Anti-Bredt Olefins (ABOs)! 🌟 As a chemist, I'm always fascinated by the mechanisms behind molecules, diving into the details, and following the references (thanks to Dr. Radhakrishnan KV, Dr. Anilkumar Gopinathan and Dr.Preethanuj Preethalayam for introducing me such fascinating bridged structures). So, when I saw this latest breakthrough (https://lnkd.in/gJAxDp7y), I was blown away! Publishing research like this is no easy feat, yet these scientists have done the "impossible." For the first time, a team has managed to create anti-Bredt olefins (ABOs)—a type of molecule scientists thought too unstable to exist. ; With these notoriously tricky molecules, researchers now have a brand-new path to crafting complex compounds. This could even help in creating drugs that were previously out of reach! Craig Williams from the University of Queensland calls it a “landmark contribution,” and I completely agree. This achievement, published in Science, is a huge win for innovation and curiosity-driven science. Hats off to the team for pushing the boundaries and making history in the lab! 🎉 Excited to see where this takes us next. Reference : https://lnkd.in/gJAxDp7y #Chemistry #ScienceNews #Innovation #DrugDiscovery #ScientificBreakthrough #NeverStopExploring

🚀 Revolutionizing Organic Chemistry: New Copper Catalyst Streamlines Furan Synthesis! 🧪 A groundbreaking advancement has emerged with the development of a copper-catalyzed annulation reaction that simplifies the synthesis of multisubstituted furans—without the need for ligands or oxidants! ✨ Key Highlights: - Broad Functional Group Compatibility: Utilizes readily available starting materials for diverse furan structures. - Practical Applications: Effective in gram-scale preparations and late-stage modifications of natural products. - Cost-Efficiency: Reduces reaction complexity and enhances large-scale production capabilities. This innovative method not only opens new avenues for advanced materials and bioactive compounds but also promises to accelerate the development of new therapeutic agents. 🌱🔬 Chemists are now equipped with a powerful tool that could lead to groundbreaking discoveries in both academic research and industrial applications. 🔗 Dive deeper into this exciting development by clicking on the link! #Catalysis #FuranSynthesis #Innovation #OrganicChemistry #Publications #ResearchBreakthroughs #MarketAccess #MarketAccessToday

Alhamdulillah. Happy to share my paper "Exploring antimalarial potential: Conjugating organometallic moieties with organic fragments for enhanced efficacy" has been published in the Bioorganic Chemistry journal. In this review paper, we explored the developments in the design of organometallic antimalarial complexes for the past decade (2010-present). We hope that this review paper may be beneficial for those who are actively working in this field. Feel free to check it out here: https://lnkd.in/gnvkXKeR You can read it for free until 22 July 2024. #antimalarial #PhD #chemistry #organometallic

Straightforward Path to Cyanoformamides Author: ChemistryViews courtesy: Chemistry Views Cyanoformamides (RHN–C(=O)–CN) are useful intermediates in organic synthesis, e.g., for the preparation of heterocycles. However, their synthesis can require toxic CN-containing species and other hazardous reactants. Vittorio Pace, University of Vienna, Austria, and University of Turin, Italy, and colleagues have developed a method for the straightforward preparation of cyanoformamides that is based on cyanide release from a suitable precursor in the presence of electrophilic isocyanates. The team used PhMe2SiCN as a cyanide “reservoir”, which releases CN– at a fast rate upon the formation and collapse of a complex with the Lewis base potassium tert-amylate (KOtAm). The researchers reacted a variety of widely available isocyanates with different aromatic or aliphatic substituents with PhMe2SiCN in the presence of catalytic amounts of KOtAm in tetrahydronfuran (THF). The desired cyanoformamides were obtained within 1 min in high to excellent yields. Chemoselective Synthesis of Cyanoformamides from Isocyanates and a Highly Reactive Nitrile Anion Reservoir, Margherita Miele, Laura Castoldi, Alexander Prado-Roller, Luisa Pisano, Vittorio Pace, Eur. J. Org. Chem. 2024. https://lnkd.in/dhuMm7kF

Assalamualaikum and greetings for a wonderful day. With high spirits from the start of the new semester in UiTM, I concluded my first task in the Biocatalyst class taught by Dr. Amizon Azizan. Thank you for allowing me to learn more in-depth about this topic. This poster will help you to gain a better understanding of the difference between biocatalysts and chemical catalysts. References: 1. Biocatalysis by Elizabeth L. Bell and William Finnigan (Nature, Jun 2021) 2. Biocatalysis: Enzymatic Synthesis for Industrial Applications by Shuke Wu and Jeffrey C Moore (ResearchGate, Jun 2020) 3. Speeding up reactions: biological vs chemical catalyst by S.E. Gould (SCIAM, January 2014) #biocatalyst #biocatalysis #bioprocess #chemicalengineering #decarbonization #industry #engineering #reactor #bioreactor #sustainability

Introducing 77-0350: an innovative Iridium photocatalyst used in organic transformations. This compound not only enables the decarboxylative cross-coupling of oxalates through metallaphotoredox catalysis (as demonstrated in groundbreaking research: https://lnkd.in/gSmCrRXn), but is also a photocatalyst for synthesizing a range of alkynes with impressive yields by the direct reaction of readily available carboxylic acids with ethynylbenziodoxolone (EBX) reagents (https://lnkd.in/gRYZ6wkH). Explore the potential of 77-0350 in advancing your organic chemistry endeavors! https://bit.ly/3vkEZZp"

Violaceoids A-F and eutyscoparols A-G are a group of bioactive compounds recently isolated from fungi that are believed to have promising antimalarial and antibacterial properties. Since their discovery, there have been efforts to synthesize them in the laboratory in sufficient quantities for further study. In a study featured on the cover of Volume 13, Issue 7 of the Asian Journal of Organic Chemistry, scientists from Tokyo University of Science (TUS) have successfully synthesized these compounds from dinitriles on a subgram scale. The proposed approach takes about nine steps and increases the yield to about 30%. The method is an improvement over previous methods and can lead to the development of new drugs. Read the official press release on the university website here: https://ow.ly/r7x150STO48 #ResearchNews #TokyoUniversityOfScience # Violaceoid #Eutyscoparol #NaturallyOcurringCompounds #BioactiveCompounds #Antimalarial #Antibacterial #Drugdevelopment #DrugDiscovery

"Catalyst-Free, Three-Component Synthesis of Amidinomaleimides" 📚 Summary 👨🏫 A recent study from The Journal of Organic Chemistry, from American Chemical Society - Division of Organic Chemistry presents a new catalyst-free three-component reaction for synthesizing amidinomaleimides. Thanks to the authors from the Gregory Weiss team from UC Irvine. Mechanism Insights 🔬 The reaction proceeds through a 1,3-dipolar cycloaddition, starting with the formation of an enamine from the secondary amine and aldehyde. This enamine then reacts with the electrophilic azidomaleimide, forming a triazoline intermediate, which subsequently undergoes ring-opening to yield the amidinomaleimide product. Why It’s Interesting 💡 - Efficiency : The reaction is high-yielding, modular, and works under mild conditions, hence perfect for scalable synthesis. - Versatility : It offers broad substrate scope, making it ideal for creating complex molecules in medicinal chemistry and natural product synthesis. #Chemistry #OrganicChemistry #DrugDevelopment #Amidinomaleimides #MedicinalChemistry

I'm thrilled to announce the publication of my latest research paper, "Fluoroalcohols for chemical modification of biomolecules" in Tetrahedron Chem! 🧪✨ In this review, we explore the emerging role of fluoroalcohols, like trifluoroethanol (TFE) and hexafluoroisopropanol (HFIP), in bioconjugation. These solvents are making waves in chemical modification processes for biomolecules, including polypeptides, nucleic acids, and saccharides. Their unique properties, such as proton shuttling, reversible adduct formation, and compatibility with electrochemistry and photochemistry, are driving innovation in the field. Key highlights include: 🔹 Enhanced chemical modifications facilitated by fluoroalcohols 🔹 Combination of fluoroalcohols with other solvents for improved reaction outcomes I'm incredibly proud of this work and excited about the potential applications in various chemistry fields. Read the full paper here: [https://lnkd.in/eGWqG_SU] #Bioconjugation #Fluoroalcohols #chempack #ncstate