iLifeXtend’s Post

🔬Researchers have identified microbial biomarkers in lupus and IBD, unlocking new pathways for targeted therapies. 🧬✨ 📚Read more: https://bit.ly/4djbirK 🦠 These findings could revolutionize the treatment for autoimmune diseases, offering more personalized and effective treatment options. 💊🩺 🌟 Imagine a future where therapy is tailored to each patient's unique microbial signature, leading to improved outcomes! 📈 💡Stay ahead in your field by exploring the latest in biomarker research! Credit: Annals of Rheumatic Diseases #Lupus #IBD #Microbiome #TargetedTherapies #PrecisionMedicine #HealthcareInnovation #AutoimmuneDiseases #eMednews

📃Scientific paper: Postdiagnosis body fatness, recreational physical activity, dietary factors and breast cancer prognosis: Global Cancer Update Programme (CUP Global) summary of evidence grading Abstract: Based on the Global Cancer Update Programme, formally known as the World Cancer Research Fund/American Institute for Cancer Research Continuous Update Project, we performed systematic reviews and meta‐analyses to investigate the association of postdiagnosis body fatness, physical activity and dietary factors with breast cancer prognosis. We searched PubMed and Embase for randomised controlled trials and longitudinal observational studies from inception to 31 October 2021. We calculated summary relative risks (RRs) and 95% confidence intervals (CIs) using random‐effects meta‐analyses. An independent Expert Panel graded the quality of evidence according to predefined criteria. The evidence on postdiagnosis body fatness and higher all‐cause mortality (RR per 5 kg/m(2) in body mass index: 1.07, 95% CI: 1.05‐1.10), breast cancer‐specific mortality (RR: 1.10, 95% CI: 1.06‐1.14) and second primary breast cancer (RR: 1.14, 95% CI: 1.04‐1.26) was graded as strong (likelihood of causality: probable). The evidence for body fatness and breast cancer recurrence and other nonbreast cancer‐related mortality was graded as limited (likelihood of causality: limited‐suggestive). The evidence on recreational physical activity and lower risk of all‐cause (RR per 10 metabolic equivalent of task‐hour/week: 0.85, 95% CI: 0.78‐0.92) and breast cancer‐specific mortality (RR: 0.86, 95% CI: 0.77‐0.96) was judged as limited‐suggestive. Data on dietary factors was limited, and no conclusions coul... Continued on ES/IODE ➡️ https://etcse.fr/Nd5w ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

From their abstract Despite recent progress in our understanding of the association between the gut microbiome and inflammatory bowel disease (IBD), the role of microbiome biomarkers in IBD diagnosis remains underexplored. Here we developed a microbiome-based diagnostic test for IBD. By utilization of metagenomic data from 5,979 fecal samples with and without IBD from different geographies and ethnicities, we identified microbiota alterations in IBD and selected ten and nine bacterial species for construction of diagnostic models for ulcerative colitis and Crohn’s disease, respectively. These diagnostic models achieved areas under the curve >0.90 for distinguishing IBD from controls in the discovery cohort, and maintained satisfactory performance in transethnic validation cohorts from eight populations.

🔬 Breakthrough in Prostate Cancer Management: Diet as a Potential Game-Changer! 🥗 A groundbreaking UCLA study just revealed something remarkable: strategic dietary interventions could be a powerful tool in managing early-stage prostate cancer. By carefully modulating omega-6 and omega-3 intake, researchers observed a significant 15% reduction in cancer cell proliferation among patients on active surveillance. Key insights for healthcare professionals: • Nutritional strategies are emerging as a complementary approach to traditional cancer management • Personalized dietary interventions could potentially slow cancer progression • Non-invasive approaches are gaining critical research momentum This research underscores the growing intersection of precision nutrition and oncology. As healthcare continues to evolve towards more holistic, patient-centered models, understanding these dietary mechanisms becomes increasingly crucial. While more extensive studies are needed, this represents a pivotal moment in supportive cancer care strategies. Are we witnessing the early stages of a paradigm shift in how we approach cancer management? I'm keen to hear your thoughts. How might this research transform patient care protocols in the future? #PrecisionNutrition #CancerResearch #Healthcare #MedicalInnovation #Oncology #PersonalizedMedicine Would love to hear your perspectives in the comments! 👇

New research uncovers surprising insights into the gut microbiome! 🦠💡 Recent findings indicate that fluctuations in gut microbial load, rather than specific bacteria, may be the primary factor driving many gastrointestinal diseases. This breakthrough challenges traditional beliefs about the origins of conditions like inflammatory bowel disease (IBD) and colorectal cancer. Explore the full article to discover how these insights could reshape our understanding of gut health and disease: https://lnkd.in/eP8qSAwT

Specific #microbiota may predispose to #myeloproliferative neoplasms [#MPNs] (#polycythemia_vera, #essential_thrombocythemia, #chronic_myeloid_leukemia, etc.). [Human] [Cohort study] Notes: - Lower relative abundance of #Phascolarctobacterium in patients with MPN. - Phascolarctobacterium may protect from inflammation; thus, lower Phascolarctobacterium in MPN patients corroborates a chronic inflammatory state in this disease. - Microbiomes of MPN patients were enriched for genes involved in d-#Glucuronate metabolism. - Changes in abundances of β-d-glucuronidases are associated with colon cancer and other inflammatory diseases  - Increased Phascolarctobacterium is associated with benefits that include protection from #Clostridium_difficile infection and lower levels of #C_reactive_protein (#CRP). - Decreased abundance of #Phascolarctobacterium is observed in autoimmune diseases such as #Primary sclerosing cholangitis and ulcerative #Colitis - Phascolarctobacterium may be associated with decreases in the short-chain fatty acid #Propionate in the gut, which, in turn, can influence inflammation. - Increased plasma concentrations of tumor necrosis factor alpha (#TNF_α) and interferon gamma-inducible 10-kDa protein (IP10) in MPN patients. - TNF-α plays a critical role in MPN pathogenesis by creating an environment that is conducive to the growth of the neoplastic clone. - #Veillonella stimulates TNF-α production of peripheral blood mononuclear cells in a dose-dependent fashion. - A species of #Parabacteroides to be enriched in patients with colorectal carcinoma. - #Parabacteroides abundance was negatively correlated with intake of fruits and vegetables.

I’m excited to share that our review article in Nature Reviews Cancer is now online! Here, we explore how metabolic disorders like obesity, fatty liver disease, and type 2 diabetes not only alter the immune system—leading to chronic inflammation—but also increase the risk of developing various cancers, particularly in the gastrointestinal tract. The review dissects the roles of macrophages and T cells in these conditions, and how their altered functions can regulate oncogenesis. Additionally, I discuss therapeutic approaches, such as diets, metformin, statins, and GLP1-R agonists, which not only treat metabolic disorders but also show potential in modulating cancer and immune responses. Understanding the mechanisms linking metabolic disorders and cancer could open up new avenues for tackling these interconnected epidemics. A huge thank you to leila akkari for her invaluable supervision and input, and to Daan Kloosterman for creating such fantastic figures! I deeply appreciate your contributions and all the insightful discussions we had throughout the process of crafting this manuscript! Enjoy the read! #Macrophage #Tcell #Cancer #Obesity #MASH #Diabetes #Metabolism #TumorMicroenvironment

Olive oil consumption is associated with lower cancer, cardiovascular and all-cause mortality among Italian adults: prospective results from the Moli-sani Study and analysis of potential biological mechanisms https://lnkd.in/eDzD6z3u

Olive oil consumption is associated with lower cancer, cardiovascular and all-cause mortality among Italian adults: prospective results from the Moli-sani Study and analysis of potential biological mechanisms https://lnkd.in/eDzD6z3u

Obesity is now linked to 32 types of cancer and might be fuelling 40% of cases, shock study warns https://lnkd.in/gtbPvm5H The stark roll it plays in the deadly disease is even greater than feared, according to research involving 4.1million adults. World’s largest review finds Ultra-processed food linked to 32 harmful effects to health with direct associations of higher risks of #cancer, #heartdisease and #earlydeath https://lnkd.in/g_fCZAZB It’s been estimated that we lose at least 13 years by eating a typical U.S. diet. https://lnkd.in/g5FJx2Kh Ultra-processed food isn't just bad for your health—it messes with your mind https://lnkd.in/gTvU_Xwj