Immunoendocrinology’s Post

I am extremely happy to announce that our new article "Immunostimulatory effects of isomalto/malto-polysaccharides via TLR2 and TLR4 in preventing doxycycline-induced cytokine loss" has been published in #CarbohydratePolymers (IF 10.7). This study reveals how isomalto/malto-polysaccharides (IMMPs)—prebiotic α-glucans commonly used as food ingredients—go beyond their dietary benefits to exert direct immunostimulatory effects by engaging TLR2 and TLR4. We found that: ✅ IMMPs activate TLR2 and TLR4, leading to a significant increase in NF-κB signaling. ✅ Enhanced cytokine production, including IL-8, TNFα, and IL1-RA, in immune cells. ✅ IMMPs help mitigate the immune-attenuating effects of doxycycline, an antibiotic that can paradoxically impair immune function. ✅ Molecular docking analysis supports IMMPs' direct interaction with TLRs, highlighting their therapeutic potential. This was a long collaborative effort, and I want to thank all the co-authors: Adil Ijaz, P. Buwalda, Sonia Kassai, Cynthia Klostermann Hans Leemhuis, Edwin Veldhuizen, Henk Schols Gabriel Lopez, and Paul de Vos for their dedication and contributions! Immunoendocrinology 🔗 Check out the full article here: https://lnkd.in/eeau8Ewz #Science #Immunology #FoodScience #Research #IMMPs #TLRs #ImmuneHealth #Prebiotics #Antibiotics #Collaboration

Unlocking the Omega-3 and Cancer Connection! 🧬🔬 In the seAFOod trial, researchers found APOE genes impact omega-3 levels in those undergoing colonoscopy after colorectal polyps removal, a key cancer prevention step. Key findings: 🔹 APOE2/2 = Lower omega-3 levels 🔹 APOE4/4 = Higher omega-3 levels After 6 months of 2g EPA daily, omega-3 levels balanced out, but APOE4 carriers had lower 18-HEPE levels. This groundbreaking study highlights the role of APOE genes in personalizing nutrition for cancer prevention. 🌊 #CancerPrevention #HealthScience #PersonalizedNutrition #Omega3 #Genetics For more info, check out our site https://lnkd.in/diBi-RN

💎💎💎Whatsapp!! 💎💎💎 Milk and Meat Proteins & Cancer-Blocking Scientists Uncover New Cancer-Blocking Benefits of Milk and Meat Proteins Researchers in Japan found that #food #antigens like milk #proteins #suppress #tumor #growth in the small intestines by activating #immune #cells. This suggests that antigen-free diets could pose risks, emphasizing the need for #medical #supervision when adopting such #diets. ➡ 💎 You can find more pieces of work by clicking here. https://lnkd.in/d6GTz22c #Milk #Meat #Proteins #Cancer_Blocking

Join Us for our Next APRIL Virtual Meeting! 🗓️💻⁣ ⁣ Topic: Immunonutrition and Cancer Who (Presented By): Jonathan Voss, Pharm. D., BCCCP, BCNSP When: Wednesday, April 3, 2024 @ 6:30 PM⁣ Where: Virtual on Zoom⁣ How (to Register): Visit https://lnkd.in/dCC85EAB Learning Objectives: - Define immunonutrition - List potential benefits for immunonutrition in cancer - Review current guidelines for nutrition support and immunonutrition for the oncology patient - Review the literature regarding immunonutrients for the oncology patient: Glutamine, ω-3 Fatty Acids, Immune-Enhancing Formulas, Combination: Arginine, nucleotides, ω-3 FA and Antioxidants - Discuss the literature regarding the Ketogenic Diet (KD) in patients with cancer | #DallasDietitians #Nutrition #DFWDietitian #DDA #NutritionEducation #TrendingDietitian #CancerNutrition #Oncology #OncologyNutrition

In this recently published randomized, controlled 120 stroke patients received either a #postbiotic supplement derived from Lactobacillus paracasei or a placebo for 7 days (n = 60 patients/treatment group). Significant reductions in biomarkers of #inflammation, #oxidativestress, and a reduced incidence of pneumonia were observed in the postbiotic-supplemented group. It would be interesting to see is supplementation of #animalfeed with the postbiotic would potentially lead to improves #animalhealth outcomes. #postbiotics #animalnutrition #animalhealth https://lnkd.in/g4cAGuN4

New (pre-print) publication alert from our lab: New Insights on Antibiotics, Blastocystis, and the Gut Microbiome in IBS Patients Excited to share our latest research on how antibiotics impact the gut microbiome and Blastocystis in IBS patients. Our study reveals significant changes in microbiome diversity and metabolite composition during and after a 14-day antibiotic course. 🔬 Key Findings: Microbiome Diversity: Antibiotics caused a temporary decline in diversity, but recovery was observed post-treatment. Blastocystis showed resilience, re-emerging after treatment. Metabolite Fluctuations: Notable changes in short-chain fatty acids (SCFAs) and amino acids highlight the profound impact of antibiotics on gut health. 💡 Implications: Cautious use of antibiotics is crucial for IBS management to maintain a balanced gut microbiome. These findings pave the way for more effective, targeted therapies. 🙏 Acknowledgments: Thanks to Jamie Newton, William Edwards, Gary Thompson and Eleni Gentekaki for putting together this amazing work! #Research #GutHealth #Microbiome #IBS #Antibiotics #Metabolomics #Blastocystis 🔗 Read More: https://lnkd.in/eJHnPxyS

More natural alternatives that activate #GLP1 The soluble protein hydrolysate ProGo, derived from upcycled Atlantic salmon, may activate the GLP-1 receptor, presenting a natural option in #weightmanagement via NutraIngredients https://lnkd.in/eR9Hs7jk The study "Initial Exploration of the In Vitro Activation of GLP-1 and GIP Receptors and Pancreatic Islet Cell Protection by Salmon-Derived Bioactive Peptides" https://lnkd.in/eCa8_fpt investigates how a soluble protein hydrolysate (SPH) from Atlantic salmon may support #weightloss and #metabolichealth by stimulating specific receptors and protecting pancreatic cells. In lab tests, SPH showed a dose-dependent increase in the activity of two key receptors, GLP-1 and GIP, by 2.4 and 2.6 times at higher concentrations compared to a control. SPH also promoted pancreatic cell growth by up to 57%, potentially protecting these cells from #inflammation related damage. Notably, the smallest #peptide fraction of SPH showed GLP-1 activity similar to #semaglutide a popular weight management medication, suggesting SPH’s potential for regulating metabolic processes. These findings indicate that SPH may boost metabolic signaling and protect pancreatic cells, making it a promising #dietary option to help manage age-related metabolic challenges, including #weightgain and #metabolic shifts during #menopause #nutrigenomics #biotech #nutrition #femtech

In our latest study, we present an updated model for #SLC30A10 deficiency. We found that the #manganese (#Mn) export protein SLC30A10 regulates dietary Mn #absorption, working closely with #iron #transporters. https://lnkd.in/gyCit6DN #Genetics This work shifts our current understanding of SLC30A10 disease. We discovered that not only impaired excretion but also increased dietary Mn absorption contributes to the SLC30A10 disease. Details on impaired excretion at @jclinicalinvest https://lnkd.in/g3wuDQ6K Using multiple mouse models, we show that intestinal SLC30A10 functions as a crucial regulator of systemic Mn levels. Disruption of this protein leads to increased dietary Mn absorption, highlighting its pivotal role. The role of iron transporters #DMT1 (#SLC11A2) and #ferroportin (#Fpn, #SLC40A1) in Mn uptake have been debated. Our findings suggest that these proteins can transport Mn in addition to Fe, but only under specific conditions. The correction of #hepcidin level in Slc30a10 mice lowers systemic Mn. Suggesting potential for therapeutic intervention for SLC30A10 patients. This research also sheds light on why oral iron supplementation is effective for patients with SLC30A10 mutations. We propose that iron competes with Mn for absorption via DMT1 or ferroportin in these patients, thereby reducing dietary Mn uptake. Additionally, Our findings explain why phlebotomy increases blood Mn levels in SLC30A10 patients: blood loss triggers Fe deficiency....to meet the demand body increases iron absorption, which inadvertently raises Mn absorption. Our prior work @JCI_insight reported unexplained reductions in systemic Mn levels with hepatic Hif2α deletion. The current study provides experimental evidence to explain this phenomenon. For more details, check out the discussion in the pre-print! https://lnkd.in/er9_wUGr 🎯 Take home message:- SLC30A10 deficiency results in impaired gastrointestinal Mn excretion + aberrant dietary Mn absorption leading to #HMDPC (Hypermanganesemia, Dystonia, Polycythemia, Cirrhosis) Thanks to all the authors!

Short-chain fatty acids: linking diet, the microbiome and immunity 🔹 SCFAs in Focus: Butyrate, propionate, and acetate are crucial microbial metabolites influenced by diet and antibiotic use. 🔹 Diverse Impact: These SCFAs play a pivotal role in maintaining gut integrity and modulating both mucosal and systemic immunity through mechanisms like G protein-coupled receptor signaling and histone deacetylase inhibition. 🔹 Butyrate's Role: Specifically, butyrate is notable for its anti-inflammatory effects, impacting various cell types including intestinal epithelial cells and various immune cells. 🔹 Beyond the Gut: SCFAs also exert significant effects on immunity in other organs such as the liver, lungs, and brain, influencing a wide spectrum of conditions from autoimmune diseases to cancer therapy responses. 🔹 Future Directions: Understanding the microbial ecology and metabolic interactions opens new avenues for SCFA-focused interventions, including the potential for engineering beneficial butyrogenic bacteria. link: https://lnkd.in/gYsMi5tR #ShortChainFattyAcids #SCFAs #GutHealth #Microbiota #Butyrate #Propionate #Acetate #ImmuneSystem #AntiInflammatory #GutBrainAxis #NutritionScience #MicrobialMetabolites #HealthInnovation #DietAndHealth #GutMicrobiome

For decades, we were taught that oxidative stress is bad, and antioxidants are good. While that is true in many cases, there are important exceptions . This new publication demonstrates that a pro-oxidant diet can have a beneficial effect in animal models of two very different diseases, a common cancer and a rare muscular disease. Perhaps a future shared molecular etiology basket trial? (https://lnkd.in/eHhc-U9v) #sharedmolecularetiology #SaME https://lnkd.in/eUfXpdYV