Medicine’s Post

Ophthopedia Update:Strategic combination of cultivated oral mucosal epithelial transplantation and postoperative limbal-rigid contact lens-wear for end-stage ocular surface disease: a retrospective cohort study: Purpose To provide the long-term outcome of patients with end-stage severe ocular surface disease (OSD) consecutively treated with cultivated oral mucosal epithelial transplantation (COMET) followed by limbal-rigid contact lens (CL)-wear therapy. Design Retrospective cohort. Methods In 23 eyes of 18 patients with severe OSD who underwent COMET surgery between 2002 and 2019 and who were followed with limbal-rigid CL-wear therapy for at least 1 year postoperative, patient demographics, best-corrected visual acuity (BCVA, logMAR), Ocular Surface Grading Scores (OSGS), surgical indication and adverse events were reviewed. Primary and secondary outcomes were BCVA and OSGS changes at baseline and final examination, respectively. Results This study involved 16 patients with Stevens-Johnson syndrome and 2 patients with mucous membrane pemphigoid (mean age: 59±15 years). The indications for COMET were as follows: corneal reconstruction for vision improvement (10 eyes (43.5%)), corneal reconstruction for persistent epithelial defect (4 eyes (17.4%)) and conjunctival (fornix) reconstruction for symblepharon release (9 eyes (39.1%)). The mean duration of CL-wear postsurgery was 6.4±3.9 years (range: 1.4 to 13.3 years). The mean BCVA at baseline and at final follow-up was logMAR 1.9±0.5 and 1.3±0.7, respectively (p #Ophthalmology #Ophthotwitter #BJO

Place of urolithiasis in the spectrum of urological pathologies, practices and use of endourological procedures in the management of calculi of the upper urinary tract: results of a survey of referral centres in Africa >>> Abstract : Our aim was to determine the current trend of endourology in the management of upper urinary tract calculi in Africa reference centres. We conducted an online multiple-choice questionnaire survey involving 46 centres from 27 countries using a structured well-designed Google Form (®) questionnaire. The questionnaires were distributed to the head of service through their emails. The questions collected demographic data about the centre, the epidemiology of urolithiasis, diagnostic means and management of upper urolithiasis, especially access to endourology procedures and their practices. Descriptive analyses were performed. The participation rate was 77.9%. Urinary lithiasis was one of the three main pathologies encountered in 42/46 centres. 33 centres had easy access to CT scanners and 34 had operating theatres equipped with endo-urological surgery equipment. Of these 34 centres, 30 perform endourology for the management of upper urinary tract stones. Rigid ureteroscopy is the main technique used by the centres. It is the only endourology technique used for stone management by 12 centres (40%). 7/30 (23.3%) have the option of performing rigid ureteroscopy, fexible ureteroscopy and percutaneous nephrolithotomy. The frequency of procedures varies widely, with 43.3% rarely performing endourological surgery. Seventeen centres have their operating theatre equipped with a fuoroscope and 6/42 centres have extracorporeal lithotripsy. Open surgery is still used in 29/42 centres (69.1%). Laparoscopy is available in 50% of centres, but none reported performing laparoscopic lithotomy. In Africa, urinary lithiasis plays an important role in the activities of referral centres. Modern management techniques are used to varying degrees (not all centres have them) and with very variable frequency. Open surgery is still widely performed as a management. Rigid ureteroscopy is the main endourological technique. It is essential to develop the practice of modern urology in Africa, mainly endourology.

https://lnkd.in/gCk8j6sW Article title: EGFR Inhibitors for Neoadjuvant and Adjuvant Therapy of NSCLC   Author(s): Fabio Villa*   Journal: Journal of Surgery and Surgical Research   Journal ISSN: 2455-2968 Abstract: 5-year survival rates of Non-Small Cell Lung Cancer (NSCLC) remain unsatisfactory after surgery with curative intent and disease recurrences, including distant metastases, are frequent. Only a minority of this heterogeneous disease is positive for EGFR mutations and suitable for Tyrosine Kinase-Inhibitor biological agents, which however present limits in terms of stable response to treatment, due to the acquired drug resistances. A few trials administrating EGFR inhibitors combined with surgery, in neoadjuvant or adjuvant settings, have been reported with lack of evidence. The third-generation EGFR inhibitors, with the amelioration of techniques of gene profiling and the knowledge of pathways could extent the spectrum of complementary-to-surgery treatments in NSCLC at high risk of relapse. #NonSmallCellLungCancer #EGFR #Adjuvant #Neoadjuvant #ThoracicSurgery #GeneralSurgery #Anesthesia #EndocrineSurgery #OncologicSurgery #TraumaSurgery #GastrointestinalSurgery #VascularSurgery #EndovascularSurgery #TransplantationSurgery #PediatricSurgery #Neurosurgery #CosmeticSurgery #MaxillofacialSurgery #OralSurgery #DentalSurgery #OphthalmicSurgery #UrologicSurgery #ColonSurgery #RectalSurgery #HandSurgery #FootAndAnkleSurgery #OrthopedicSurgery #LaserSurgery #Peertechz #PeertechzPublications #OpenAccess #ScientificJournals #PeerReviewedJournals #OpenAccessPublishers #ReconstructiveSurgery #PlasticSurgery #CardiacSurgery #GynecologicalSurgery #Microsurgery #ThoracicSurgery #ComputerAssistedSurgery #CAS #RoboticSurgery #InvasiveSurgery #NonInvasiveSurgery #SurgicalProcedures #SurgicalInstruments #HeadAndNeckSurgery #BreastSurgery #ColorectalSurgery #DermatologicSurgery #HepatobiliarySurgery #PancreaticSurgery #SurgicalOncology #BoneSurgery #BurnSurgery #CerebralSurgery #CardiovascularSurgery #ExperimentalSurgery #BariatricSurgery #EpilepsySurgery #AbdominalSurgery

https://lnkd.in/guU-Tcr4 Article title: Current medical and surgical management of lung cancer   Author(s): Shereen Ajab*; Jack A Kastelik; Mahmoud Loubani   Journal: Journal of Surgery and Surgical Research   Journal ISSN: 2455-2968 Abstract: Lung cancer is the most commonly diagnosed malignancy and a leading cause of cancer related deaths accounting for 1.8 million deaths worldwide in 2018 [1]. In recent years, the investigation and management of lung cancer has significantly changed with emerging evidence that rapid investigations may improve survival. For example, the randomised controlled trial, LungBOOST compared conventional diagnosis and staging to endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) following staging Computer Tomography (CT). #MinimallyInvasiveSurgery #Bronchoscopy #EndobronchialUltrasound #EndoscopicUltrasound #NonSmallCellLungCancer #Segmentectomy #Phototherapy #Radiotherapy #Chemotherapy #Immunotherapy #GeneralSurgery #Anesthesia #EndocrineSurgery #OncologicSurgery #TraumaSurgery #GastrointestinalSurgery #VascularSurgery #EndovascularSurgery #TransplantationSurgery #PediatricSurgery #Neurosurgery #CosmeticSurgery #MaxillofacialSurgery #OralSurgery #DentalSurgery #OphthalmicSurgery #UrologicSurgery #ColonSurgery #RectalSurgery #HandSurgery #FootAndAnkleSurgery #OrthopedicSurgery #LaserSurgery #Peertechz #PeertechzPublications #OpenAccess #ScientificJournals #PeerReviewedJournals #OpenAccessPublishers #ReconstructiveSurgery #PlasticSurgery #CardiacSurgery #GynecologicalSurgery #Microsurgery #ThoracicSurgery #ComputerAssistedSurgery #CAS #RoboticSurgery #InvasiveSurgery #NonInvasiveSurgery #SurgicalProcedures #SurgicalInstruments #HeadAndNeckSurgery #BreastSurgery #ColorectalSurgery #DermatologicSurgery #HepatobiliarySurgery #PancreaticSurgery #SurgicalOncology #BoneSurgery #BurnSurgery #CerebralSurgery #CardiovascularSurgery #ExperimentalSurgery #BariatricSurgery #EpilepsySurgery #AbdominalSurgery

Happy Valentine's Day! 💘 We are proud to endorse NYU Langone Health's Event, "4th Annual Cardiometabolic Risk in Inflammatory Conditions: Emerging Insights and Treatment of Inflammation in Cardiovascular Disease" on April 26, 2024! This special one-day course will cover state-of-the-art topics regarding management of patients at higher risk of cardiovascular and cardiometabolic disease due to underlying systemic inflammation. This course is specially designed to provide an informative and practical guide for the clinical management across a wide spectrum of cardiovascular conditions in patients with systemic inflammation, those at risk for accelerated atherosclerosis and recurrent pericarditis, and autoimmune conditions including rheumatoid arthritis, systemic lupus erythematosus, and scleroderma.  This course is offered both in-person and online! This special program is organized by NYU Langone's Center for the Prevention of Cardiovascular Disease in collaboration with the Brigham and Women's Hospital.    To register, please visit: https://lnkd.in/g49wfpMa Co-endorsers for this event are: American College of Cardiology, New York State Chapter, CONNECTICUT CHAPTER OF THE AMERICAN COLLEGE OF CARDIOLOGY, and MASSACHUSETTS CHAPTER AMERICAN COLLEGE OF CARDIOLOGY. Photo Credit: NYU CVD Prevention X Account #Dermatology #Dermatologist #DermPath #Scleroderma #CardiovascularHealth #CardiovascularDisease #AutoimmuneDisease #Autoimmune #Inflammation #Lupus #LupusAwareness #SystemicLupus #Rheumatology #RheumatoidArthritis #RheumatoidArthritisAwareness #NYU #NYULangone #Cardiometabolic

Sharing the first of many promising studies about the value of Calprotectin in early diagnosis of PJI (Prosthetic Joint Infection)!

Lumbar degenerative disease is frequent and has a tremendous impact on patients’ disability and quality-of-life. Open and minimally invasive procedures have been used to achieve adequate decompression and fusion. Endoscopic lumbar interbody fusion (Endo-LIF) is emerging as an alternative, trying to reduce morbidity, while achieving comparable to superior clinical outcomes. The aim of this work is to perform a systematic review and meta-analysis to investigate how Endo-LIF compares to open or minimally invasive procedures. Electronic databases (MEDLINE, Scopus, Web of Science, Cochrane) were systematically reviewed using the query: ‘(percutaneous OR endoscop*) AND (open OR minimal* invasive) AND lumbar AND fusion’. PRISMA guidelines were followed. Twenty-seven articles were included (25 cohort study, 1 quasi-experimental study, and 1 randomized control trial; for meta-analytical results, only observational studies were considered). Endo-LIF conditioned longer operative time, with significantly lower blood loss, bedtime, and hospital length of stay. Early post-operative back pain favored endoscopic techniques. Endo-LIF and non-Endo-LIF minimally invasive surgery displayed comparable results for most back and leg pain or disability outcomes, despite Endo-LIF having been associated with higher disability at late follow-up (versus Open-LIF). [...] Endo-LIF is an effective and safe alternative to conventional lumbar interbody fusion procedures. Evidence shortcomings may be addressed, and future randomized control trials may be performed to compare techniques and to validate results. Read more on 📄 Is endoscopic technique an effective and safe alternative for lumbar interbody fusion? A systematic review and meta-analysis https://bit.ly/3YMZdHZ ✒️ Miguel Relvas-Silva, Bernardo Sousa Pinto, António Sousa, Miguel Loureiro, André Rodrigues Pinho, and Pedro Pereira #lumbar #spine #opensurgery #minimallyinvasivesurgery #endoscopicsurgery #lumbarinterbodyfusion #lumbardegenerativedisease #OpenReviews #orthopedics #orthopaedics #surgery #openaccess

#Perino- h #Flex: The Next Generation #Transperineal #Prostate #Biopsy #Guide 😎 💪 👍 We are excited to introduce Perino-Flex, a revolutionary advancement in transperineal prostate biopsy procedures. Perino-Flex offers unparalleled versatility, precision, and ease of use, making it the ideal solution for transperineal prostate biopsy applications. Key Features: #Adjustable #Height: Perino-Flex features adjustable height settings, allowing precise needle positioning during transperineal biopsy. This ensures optimal access and accuracy, enhancing the overall effectiveness of prostate biopsy. #Angle #Adjustment Function: Perino-Flex's revolutionary angle adjustment function enables the physician to direct the biopsy needle to the prostate's anterior and posterior sections without angulating the rectum's ultrasound transducer. This capability allows for targeted sampling in critical areas, improving diagnostic accuracy. This feature ensures optimal needle trajectory, minimizes patient discomfort, and enhances the overall patient biopsy experience. #Anterior #Sector #Biopsy: Thanks to the height and angle adjustment functions, Perino-Flex enables the easy sampling of the anterior sector of the prostate, addressing a critical aspect of prostate cancer diagnosis and treatment. This capability enhances the thoroughness and accuracy of biopsy procedures. #Posterior #Peripheral #Zone #Biopsy: Perino-Flex facilitates posterior peripheral zone biopsies, providing comprehensive coverage and enabling thorough examination of the prostate gland. #Enhanced #Precision: Perino-Flex offers precise control and maneuverability, resulting in more accurate biopsy sampling. #Improved #Patient #Comfort: With Perino-Flex, the movements of the rectal ultrasound transducer are minimized. This enhances patient comfort during transperineal prostate biopsy under local anesthesia. Perino-Flex represents a significant advancement in transperineal prostate biopsy, offering versatility, precision, and ease of use. With its innovative features and capabilities, Perino-Flex empowers physicians to perform biopsies confidently, accurately, and efficiently, ultimately improving patient outcomes. For more information about Perino-Flex or to schedule a demonstration, please get in touch with us at info@geotekmedicalusa.com hashtag #usa #transperineal #fdacleared #biopsy #guide #urology #prostatecancer #care #lovedones #prostatecancerawareness #prostatehealth #menhealth #cancerresearch #cancercare #biopsy #americanurology #medicaldevicemanufacturing #fdacleared #quality #value #product #geotekmedicalusa

https://lnkd.in/erXhAW4D Key points 1-Thyroid nodules are a common occurrence, with a prevalence of ~25% in the general population that varies widely according to age, sex, and risk factors. 2-The US Preventive Services Task Force recommends against screening for thyroid cancer in the general, asymptomatic adult population, as such screening would result in harms that outweigh potential benefits. 3-If a thyroid nodule is suspected, the first step is to perform dedicated ultrasonography; ultrasonography risk stratification systems can classify and estimate the likelihood of malignancy of a nodule. 4-If the need for further assessment is confirmed, a fine-needle aspiration biopsy is often performed; cytology results are usually classified according to a standard cytology reporting system. 5-At the end of the initial diagnosis and risk stratification procedure, over 90% of nodules are found to be benign and asymptomatic; the patients are euthyroid and require no specific treatment. 6-Preservation of thyroid function is of paramount importance; several non-surgical and minimally invasive techniques are available but, if surgery is needed, the minimal possible extent should be chosen.

Learn More: https://bit.ly/3OQzU1C | The bar has been set. Mobi-C® is the only artificial cervical disc with 10 years of published clinical data for one- and two-levels. In this most recent paper written by Dr. Nunley, Dr. Hisey, Dr. Smith, Dr. Stone, and Dr. Harrop, the team found that CDA was superior to ACDF for treating symptomatic cervical DDD, and that CDA was statistically superior to ACDF for clinical success, subsequent surgery, and neurological success. Background: Over the past 20 years, multiple randomized controlled trials have shown cervical disc arthroplasty (CDA) to be safe and effective for treating 1- and 2-level degenerative disc disease (DDD). The purpose of this postmarket study is to compare 10-year outcomes between CDA and anterior cervical discectomy and fusion (ACDF) from a randomized study at 3 centers. Results: A total of 155 patients were enrolled (105 CDA; 50 ACDF). Follow-up was obtained from 78.1% of patients eligible after 7 years. At 10 years, CDA demonstrated superiority to ACDF. Composite success was 62.4% in CDA and 22.2% in ACDF (P < 0.0001). The cumulative risk of subsequent surgery at 10 years was 7.2% vs 25.5% (P = .001), and the risk of adjacent-level surgery was 3.1% vs 20.5% (P = .0005) in CDA vs ACDF, respectively. The progression to radiographically significant adjacent-segment pathology at 10 years was lower in CDA vs ACDF (12.9% vs 39.3%; P = 0.006). At 10 years, patient-reported outcomes and change from baseline were generally better in CDA patients. A higher percentage of CDA patients reported they were “very satisfied” at 10 years (98.7% vs 88.9%; P = 0.05). #spinesurgery #spinesurgeon #neurosurgeon #neurosurgery #MobiC #cervicaldiscreplacement Mobi-C is indicated for use in in skeletally mature patients for reconstruction of the disc at one or two levels from C3-C7. Common post-operative risks from surgery with the Mobi-C include pain in the neck, arm, back, shoulder, or head, and dysphagia. Full risks and contraindications can be found at cervicaldisc. com