INOVOTION’s Post

🎉 Exciting News: Our New Website is Live! 🚀 We’re thrilled to unveil the refreshed Tufts Comparative Medicine Services website—your complete hub for preclinical research support! Whether you're part of an academic institution, a biotech startup, or a global pharmaceutical company, our new site is designed with your needs in mind. Here’s what’s new: ✨ Streamlined navigation to quickly find the services you need ✨ Comprehensive details on advanced imaging, surgical services, rodent breeding, and more ✨ Resources to help you accelerate your research from concept to breakthrough Our advance facilities and expert team are here to support innovation at every stage. Whether you're pioneering new therapies, developing medical devices, or conducting foundational research, we’ve got you covered. 📲 Explore our new site today: CMS.Tufts.edu Check it out and see how we can help advance your research goals. Have feedback or questions? Drop us a line—we’d love to hear from you! #PreclinicalResearch #TuftsCMS #BiomedicalInnovation #ResearchSupport #ResearchInnovation #TuftsCMS #NewWebsiteLaunch #AnimalCare #BiomedicalResearch #Tufts

Join us on Wednesday, December 18, 2024, at 1 pm ET/7 pm CET for our next 3Rs Training Webinar, featuring Dr. Catharine E. Krebs, a member of the Coalition to Illuminate and Address Animal Methods Bias (COLAAB) and medical research program manager at the Physicians Committee for Responsible Medicine. Dr. Krebs will discuss animal methods bias, a tendency in scientific research to favor animal-based methods over non-animal alternatives, even when the latter may be more relevant, accurate, or ethical. This bias influences the design, conduct, and evaluation of research, leading to the continued use of animal models despite the availability of innovative, human-relevant methods. It often stems from traditional practices, regulatory frameworks, or misconceptions about the reliability of non-animal approaches. Tackling this bias is essential to promoting more ethical and effective research, especially in toxicology and biomedical fields. Don’t miss this important conversation on improving research practices! Register here: https://lnkd.in/dVCQmpB8 Center for Alternatives to Animal Testing (CAAT) Physicians Committee for Responsible Medicine #3Rs #webinar #training #animalmethodsbias

INOVOTION will be at the European Partnership for Alternative Approaches to Animal Testing (EPAA) Annual Conference 2024, November 13, 2024, in Brussels! This crucial event organised by the European Commission focuses on accelerating the adoption of New Approach Methodologies (NAMs) within current EU regulatory frameworks. Key themes include: - Regulatory acceptance of NAMs - Challenges in implementing NAMs across different sectors - Strategies for enhancing NAM uptake in safety assessments - Harmonizing NAM approaches across EU member states Our CEO, Jean Viallet, will be attending to engage in discussions on these vital topics. INOVOTION's 3Rs-compliant CAM model aligns perfectly with the conference's goals, offering an innovative approach to reduce animal testing while maintaining robust preclinical results. Jean Viallet looks forward to exploring how our technology can contribute to the broader adoption of NAMs in various research fields, including oncology, and how it fits within existing and evolving EU regulations. Connect with Jean Viallet at the conference to discover how INOVOTION's methods can support your research while adhering to ethical standards and regulatory requirements. Learn more about our 3Rs-compliant services: https://lnkd.in/gWQJncb Join us in advancing ethical and efficient preclinical testing at EPAA 2024! #preclinical  #drugdiscovery  #NAMs 

Our new preclinical technology screening service leverages our history of excellence in #solubility enhancement to screen different enabling technologies, improving exposure in preclinical animal models. From our facility in Nottingham, UK, three different platforms can be evaluated in less than 8 weeks. Learn more: https://lnkd.in/euUTWnvc

𝗡𝗛𝗣𝗶𝗴 𝗘𝗨 𝗣𝗿𝗼𝗷𝗲𝗰𝘁 𝗟𝗮𝘂𝗻𝗰𝗵𝗲𝘀 𝘁𝗼 𝗧𝗿𝗮𝗻𝘀𝗳𝗼𝗿𝗺 𝗡𝗼𝗻-𝗖𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 ETISENSE today announced the launch of NHPig project, an EU-funded (Innovative Health Initiative) research project aimed at transforming non-clinical safety assessment by use of mini- and micropig models. The goal is to expand and share biological knowledge on mini- and micropig models and improve the translational understanding between pig models and non-human primates (NHPs) and humans with the possibility to use these pig models as viable alternatives to NHPs in the nonclinical safety testing. For more details, please refer to the NHPig Consortium’s press release: https://lnkd.in/dmhbYGHz

ETISENSE is very honoured to be part of this new European Innovative Health Initiative (IHI) which aims to expand and share biological knowledge on mini- and micropig models and improve the translational understanding between pig models and non-human primates (NHPs) and humans with the possibility to use these pig models as viable alternatives to NHPs in the nonclinical safety testing. 👏 This is a fantastic recognition of the capabilities of our solutions to play a critical role in monitoring regulatory compliant #digital biomarkers in mini and micropigs.

🐷 ETISENSE is very honored to be part of this new European Innovative Health Initiative (Innovative Health Initiative (IHI)) which aims to expand and share biological knowledge on mini- and micropig  models and improve the translational understanding between pig models and non-human primates (NHPs) and humans with the possibility to use these pig models as viable alternatives to NHPs in the nonclinical safety testing. 👏 This is a fantastic recognition of the capabilities of our solutions to play a critical role in monitoring regulatory compliant #digitalbiomarkers in mini and micropigs. 📊 We are thrilled to start the building and the validation of an intelligent animal housing system (iPig) for continuous, automated monitoring of minipigs in their home pens allowing for a more holistic approach in pre-clinical studies. 🫀 iPig will combine digital biomarkers including ETISENSE’s Jacketed telemetry solutions for cardiorespiratory functional assessment and computer visions tools from our WP partner M3-BIORES allowing to capture key indicators of mini-pig behaviour and welfare. 📢 Follow the NHPig project for breakthroughs in ethical and efficient preclinical research! Tomas Norton, Szczepan B.,Charles Eynard

Researchers, if you're working with in vitro systems, here’s another reminder to share your insights! Humane Society International India, in partnership with IndiaBioscience and CPHMS | Centre for Predictive Human Model Systems is conducting a survey to better understand your experience submitting in vitro data for journal and grant applications. The survey includes questions, such as if reviewers of manuscripts or grants asked you to validate in vitro findings with animal data. Share your views in our survey! 🔬🧪🐁 Link: https://lnkd.in/gxx7bkxx #ResearchandToxicology #AnimalWelfare #Research #InVitro #Data #Technology

We had a look at animal-to-human translation of therapeutic interventions, and I would like to highlight two interesting results: -> The overall proportion of therapies progressing from animal studies was 50% to human studies, 40% to RCTs, and 5% to regulatory approval. But also: -> Notably, our meta-analysis showed an 86% concordance between positive results in animal and clinical studies. This seems to confirm what other studies found: Yes, only a small fraction of therapies shown to be successful in animals reach the market, but "contrary to widespread assertions, the rate of successful animal-to-human translation may be higher than previously reported." As people involved in drug development know very well, the translation success is not only a function of the concordance between animal models and human patients, but is dependent on additional factors. Nevertheless: the low rate of final approval indicates potential deficiencies in the design of both animal studies and early clinical trials. To ameliorate the efficacy of translating therapies from bench to bedside, we advocate for enhanced study design robustness and the reinforcement of generalizability. https://lnkd.in/eRrXyH3k ✍️ Authors: Benjamin Victor Ineichen Eva Furrer, Servan L. Grüninger, Wolfgang Zürrer, Malcolm Macleod #AnimalResearch #Translation #ClinicalTrials CC University of Zurich Swiss 3RCC SAVIR President Center for Reproducible Science Stiftung für das Tier im Recht (TIR) - Wir geben Tieren Recht! Interpharma Zürcher Tierschutz Schweizer Tierschutz STS German Reproducibility Network European Animal Research Association (EARA) Reatch

🐷 Very happy and proud to be a member of this NHPig project! Specifically, our research group M3-BIORES, in partnership with VeriSIM Life, will lead a work package focused on minipig-specific technologies to enable automated data collection and processing. 🧪 The end goal? An intelligent animal housing system for continuous, automated monitoring of minipigs in their home pens. 📊 Our work will focus on the 'Refine' aspect of the 3Rs (Reduce, Refine, Replace) principles, by enhancing the quality and quantity of data gathered during pre-clinical studies. Specifically, we will target the development of digital biomarkers on two different aspects of mini-pig health: Neurobehavioral Biomarkers: Using computer vision tools, we will capture subtle changes in movement that signal key indicators of mini-pig behaviour and welfare. Physiological Biomarkers: We will capture key physiological information in collaboration with our WP partner ETISENSE. We use their unique jacket telemetry technology to monitor cardiorespiratory function and overall activity. 🎯 Our impact: --> Minimize animal stress due to handling --> Maximize the collection of high-quality data from experiments --> Improve the timeliness and quality of interventions when needed Through this project, we aim to establish these technologies as essential to a more ethical, efficient, and data-driven approach to preclinical studies. 🤝 If you work in biosensors, AI, or digital animal health, let's connect and explore potential synergies! Szczepan B., Timothé Flenet