International Society of Microbiota’s Post

Our RNAi technology is designed to extend into new territories, targeting genes once deemed untreatable. From #cardiometabolic breakthroughs to strides in #pulmonary, liver, neuromuscular, and more – we're reshaping the landscape of possibilities. Learn about how we're combatting diseases with unmet needs: https://brnw.ch/21wI1im

Vidhya Vijayakumar will represent Draper at the MPS World Summit. Her poster presentation will cover the work Draper scientists and engineers have been doing on the skin microbiota, the interface between the human body and the environment. Current evaluation relies on post hoc studies. Draper is developing an in vitro model of the human skin microbiome comprising a 6-strain consortium colonizing primary human keratinocyte tissue in Air-Liquid Interface for up to seven days. This model could test and evaluate the influence of microbiome on skin diseases to better understand treatment options. Learn more: https://lnkd.in/en7ferPx #microbiome #keratinocyte #skinmicrobiota #skindiseases

Gerogenes and Gerosupressive genes! Great review about #gerogenes and aging research! The analogy drawn to cancer-relevant processes is insightful. The proposal that gerogenesis (aging) is driven by gerogenes, genes that promote aging, and the failure of gerosuppressive genes and processes, which should inhibit aging, sheds light on the complexities of the aging process. It's interesting to note that these genes and processes do not act independently within cells but impact the overall system properties of the organism, contributing to the decline in general health. #research #aging #health Kudos to all authors! Guido KROEMER Andrea B. Maier Carlos López-Otín

Let's explore the concept of a synthetic immune system. As we age, our immune system weakens, leaving us more vulnerable to infections and inflammation. This decline, known as immunosenescence, is a key factor in aging-related diseases and frailty. Microbiome imbalances, or dysbiosis, further accelerate aging by triggering chronic inflammation and disrupting cellular processes. Many researchers are now focusing on ways to restore immune function by mimicking natural antimicrobial peptides, such as LL-37, which decline with age. For example, scientists at Maxwell Biosciences are developing synthetic versions of these peptides that target a wide range of pathogens without harming beneficial microbes—essentially creating a synthetic immune system. Could this approach be the key to addressing aging at its core? Explore more about this frontier in today's full article, posted in the comments. #Geroscience #Microbiome #SyntheticBiology #AgingResearch #Biotech #Healthspan #Immunotherapy #Longevity

𝗘𝗮𝗴𝗲𝗿 𝘁𝗼 𝗠𝗼𝗻𝗶𝘁𝗼𝗿 𝗔𝘂𝘁𝗼𝗽𝗵𝗮𝗴𝘆?  Autophagy, the regulated degradation of cytoplasmic components like proteins and organelles, is crucial in the study of aging and neurodegenerative diseases. In this context, there is a growing ↗ need to determine if the increase in autophagosomes is due to autophagy induction or autolysosome inhibition. To effortlessly monitor the autophagy process and pathway, Tebubio presents the new Autophagic Flux Assay Kit by Dojindo Europe GmbH! ➡ Learn more about how this innovative tool can advance your autophagy studies and its implications in aging and neurodegenerative diseases: https://lnkd.in/empJNjKQ #Autophagy #Research #Aging #NeurodegenerativeDiseases #LifeSciences [WeAreTebubio]

BME Seminar Series presents: Exploring new frontiers in disease research 🧬 The human extracellular matrix (ECM)— a vital structure supporting our tissues— plays a key role in maintaining health. When ECM regulation is disrupted, it’s linked to various diseases, including inflammatory bowel disease (IBD). Exciting new findings from Ana Maria Porras's lab reveal how the gut microbiome might directly influence ECM remodeling in the gut and even impact distant organs! She is pioneering in vitro methods to study this connection, hinting at a paradigm shift in our understanding of ECM and its impact on disease progression. #ASUEngineering #BiomedicalResearch #Microbiome #BMESeminarSeries #Innovation

At Your Diary Targeting Extracellular Vesicles 2024 "Mitochondria and Microbiota: Crucial Impact"!   The First Conference on Targeting Extracellular Vesicles is set for October 17-18, 2024, at Corinthia Palace in Malta.   Organized by the World Mitochondria Society and the International Society of Microbiota, this event promises to be a pivotal gathering.   🔍 Explore diverse facets of Extracellular Vesicles (EVs) with a focus on mitochondria and microbiota:   Session 1: Introduction to EVs: Current Landscape & Future Prospects Session 2: EVs & Mitochondria: Insights into Biogenesis, Function, and Dynamics Session 3: Microbiota & EVs: Unveiling Roles, Disease Biomarkers, and Therapeutic Strategies Session 4: Exosomes 2024: Advances in Clinical Applications, Engineering, and Therapeutic Interventions   📨 Learn more in our February Press Release: https://lnkd.in/dEXckG8s   🌐 Visit Conference Website : https://lnkd.in/dMm8jZjd   #TargetingExtracellularVesicles #TargetingEVs #extracellularvesicles #evs #exosomes #exosome #microbiome #microbiota #redox #iron #homeostasis #skin #mitochondria #ISM #WMS

📢 New Publication Alert!  📚 Our Special Issue on "Ferroptosis: Mechanisms and Human Disease" kicks off with a study on increased vulnerability to ferroptosis in FUS-ALS. Insights into mitochondrial disturbances and susceptibility in ALS-causing FUS mutations. Exciting implications for therapeutic targets.  👉 https://lnkd.in/eArhet8s.. #Ferroptosis #ALS #Research #CellDeath 🔬🧬

Incredible results have been achieved using CAR-T therapy against autoimmune diseases, leading to remarkable remissions in patients with conditions like stiff person syndrome and myasthenia gravis. These innovative treatments involve genetically modifying T-lymphocytes to target and eliminate diseased cells responsible for autoimmune attacks. The success of CAR-T therapy in these cases offers promising insights into potential future treatments for a variety of autoimmune conditions, potentially revolutionizing the approach to managing such diseases. #CAR-Ttherapy #AutoimmuneDiseases #InnovativeTreatment #Remission #MedicalBreakthroughs Read more here: https://lnkd.in/ee7P6fkK BioMedHack.com is your leading source for the latest news, breakthroughs, and insights in medicine, biohacking, and alternative medicine. Our mission is to help you live healthier and longer by bringing you cutting-edge information and expert advice. Follow us on Facebook, Instagram, and X.

How Can Polyphenols Promote Longevity by Targeting Senescent Cells? Recent research led by Andrea Alimonti, from Università degli Studi di Padova and ETH Zürich, highlights the potential of Salvia haenkei extract, Haenkenium (HK), in promoting both lifespan and healthspan. This study reveals that HK, rich in polyphenols, can significantly reduce age-related inflammation, fibrosis, and cellular senescence markers, while improving muscle strength and fur thickness in naturally aged mice. The findings suggest that polyphenols in Haenkenium, especially luteolin, may act as senolytic agents, disrupting key aging pathways and offering new hope for extending healthspan and combating age-related diseases. 🔗 Read more: https://lnkd.in/dxMKYcfi. Don’t miss the opportunity to learn more about the impact of polyphenols on longevity and senolytic activity at #PolyphenolsApplications2024 this September! #PolyphenolsWorldCongress #PolyphenolsApplications #polyphenols #senolytics #longevity #healthspan #innovation #phytotherapy #bioactives