Jean-Christophe Sergere’s Post

💡 The article was published in Journal of Translational Medicine, called Relationship between vaginal and oral microbiome in patients of human papillomavirus (HPV) infection and cervical cancer. 🌈 The aim of this study was to assess the microbial variations and biomarkers in the vaginal and oral environments of patients with human papillomavirus (HPV) and cervical cancer (CC) and to develop novel prediction models. 🔍 Microbiota analysis was conducted using full-length 16S rDNA gene sequencing with the PacBio platform. HPV infection and CC impact both the vaginal and oral microenvironments, affecting systemic metabolism and the synergy between bacteria. This suggests that the use of oral flora markers is a potential screening tool for the diagnosis of CC. 🔬 BMKGENE provided sequencing and analysis services of full-length 16S rDNA gene for this study. #FullLength16S #Microbiome #HumanPapillomavirus #CervicalCancer #BMKGENE

📃Scientific paper: Unraveling the microRNAs, key players in folliculogenesis and ovarian diseases Abstract: Background Folliculogenesis is an intricate process that involves the development and maturation of ovarian follicles in females. During folliculogenesis, multiple factors including hormones, growth factors, and signaling pathways regulate the growth and maturation of follicles. In recent years, microRNA, short non-coding RNA molecules, has gained attention due to its roles in the physiology and pathophysiology of various diseases in humans. It is known to have an important part in ovarian health and illness and its functions extend to several cellular processes. Main body In this overview, we look at the importance of microRNAs in ovarian illnesses and how they function during follicle growth in the ovaries. Short RNA molecules (22 nucleotides) called microRNAs may influence several mRNA targets in different biological processes. The expression patterns of these small non-coding RNAs undergo dynamic changes during the several phases of follicular development; they play a function in post-transcriptional gene regulation. Follicle development, follicular atresia (regression of the follicles), and ovulation are all intricately regulated by the dynamic expression of distinct miRNAs throughout the various phases of folliculogenesis. The role of microRNAs (miRNAs), which are known to regulate gene expression, has recently come to light as crucial in the development and advancement of a number of ovarian diseases. Abnormalities of the human ovary, such as ovarian cancer,... Continued on ES/IODE ➡️ https://etcse.fr/uLQlJ ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

💡 The article was published in Journal of Translational Medicine, called Relationship between vaginal and oral microbiome in patients of human papillomavirus (HPV) infection and cervical cancer. 🌈 The aim of this study was to assess the microbial variations and biomarkers in the vaginal and oral environments of patients with human papillomavirus (HPV) and cervical cancer (CC) and to develop novel prediction models. 🔍 Microbiota analysis was conducted using full-length 16S rDNA gene sequencing with the PacBio platform. HPV infection and CC impact both the vaginal and oral microenvironments, affecting systemic metabolism and the synergy between bacteria. This suggests that the use of oral flora markers is a potential screening tool for the diagnosis of CC. 🔬 BMKGENE provided sequencing and analysis services of full-length 16S rDNA gene for this study. #FullLength16S #Microbiome #HumanPapillomavirus #CervicalCancer #BMKGENE

Sad news from a gene therapy trial aimed at treating young boys suffering from the rare and fatal genetic disease cerebral adrenoleukodystrophy (ALD). Although most of the boys showed no major disabilities an average of six years after receiving lentivirus-modified (Skysona) blood stem cells, the functional copy of the ABCD1 gene delivered during treatment was found integrated into or near cancer-related genes, as well as other genes that together may have driven uncontrolled blood cell growth. So far, 10% of the boys in the Skysona trials have developed leukemia. While lentiviral vectors have generally been considered safer than other genome-integrating retrovirus vectors, there had been some signs of concern prior to these new findings, now published in The New England Journal of Medicine (NEJM). A similar lentiviral vector has been used in other gene therapies without causing cancer, and the reasons for this discrepancy are currently under investigation. #Lentivirus #Gene_Therapy #Adverse_Effect #Cancer #Leukemia #Skysona https://lnkd.in/dFS5W7nW

Scientists have mapped all potential outcomes of alterations to the tumor-suppressing gene VHL. This marks the initial step in an extensive research effort to decipher the effects of tens of thousands of genetic variations in cancer-related genes. #Genetics #Cancer #health Buckley, M., Terwagne, C., Ganner, A. et al. Saturation genome editing maps the functional spectrum of pathogenic VHL alleles. Nat Genet (2024). https://lnkd.in/erW6yC-d

Looking for an advanced human in vitro liver model for your research? Check out our poster on "A comprehensive and scalable human liver-on-chip model for fibrosis drug discovery and gene delivery applications." MIMETAS's advanced 3D liver model mimics steatosis and fibrosis using multiple cell types (hepatocytes, endothelial, stellate, and immune cells), offering a powerful tool for studying liver health and disease. Compatible with automation and high-throughput screening, it’s paving the way for breakthroughs in therapies for liver diseases and cancer. 🔗 Download the poster now to learn more: https://lnkd.in/eanzwqam #LiverOnChip #FibrosisResearch #GeneDelivery #DrugDiscovery

🌟 The article, titled "Relationship between vaginal and oral microbiome in patients of human papillomavirus (HPV) infection and cervical cancer", was published in Journal of Translational Medicine. The aim of this study was to assess the microbial variations and biomarkers in the vaginal and oral environments of patients with human papillomavirus (HPV) and cervical cancer (CC) and to develop novel prediction models. 🔍 Microbiota analysis was conducted using full-length 16S rDNA gene sequencing with the PacBio platform. HPV infection and CC impact both the vaginal and oral microenvironments, affecting systemic metabolism and the synergy between bacteria. This suggests that the use of oral flora markers is a potential screening tool for the diagnosis of CC. 🔬 #BMKGENE provided sequencing and analysis services of full-length 16S rDNA gene for this study. #FullLength16S #Microbiome #HumanPapillomavirus #CervicalCancer

Lack in better understanding of the various factors (read: environmental) that can contribute to and even take away from either the Expression (and Under/ Over-expression) OR Suppression (and Under/ Over-suppression) of the inherited genetic palette has been a major stumbing block in the comprehension of dysplasia in tissues leading to what is known as Cancer IMHO https://lnkd.in/gpaXwYm6

Last time, after posting the article on apoptosis, a question came up: How does the mechanism of apoptosis help us understand cancer development and potential therapeutic targets? This question was posed by Dr. Reza Rahavi, from the Department of Experimental Medicine at the University of British Columbia. I thought it would be interesting to share my response. "The link between cancer cells and the apoptosis process is intriguing. Indeed, apoptosis is a crucial mechanism that eliminates damaged or abnormal cells, including those that may become cancerous. However, cancer cells often manage to evade the cell cycle checkpoints, promoting their uncontrolled proliferation and tumor growth. For potential therapeutic targets, we can: Focus on understanding the mechanisms of apoptosis by concentrating research on mutations in apoptosis-regulating genes, the imbalance between pro-apoptotic and anti-apoptotic proteins, and the signaling pathways that regulate apoptosis. Investigate the mechanisms by which cancer cells adapt to treatments that induce apoptosis, such as radiotherapy. It is likely that cancer cells have developed strategies to mimic the function of regulatory genes, like the p53 gene, which is usually altered or deactivated in these cells. Gene therapy appears to be an interesting approach to induce apoptosis in cancer cells. I am currently discussing these approaches with my gene therapy professor at the University of Orléans." #Biology #Apoptosis #CellDeath #CancerResearch #MedicalBreakthroughs