John P.’s Post

What Is The Difference Between An Inline Homogenizer & A Shear Pump? An inline homogenizer and a shear pump are both used for blending and mixing, but they have different mechanisms and applications: Inline Homogenizer Function: Inline homogenizers are designed to reduce particle size and ensure a uniform distribution of components. They work by forcing the mixture through a narrow gap or nozzle at high pressure, which creates intense shear forces and turbulence. Applications: Commonly used in the food, pharmaceutical, and cosmetic industries for creating emulsions, suspensions, and other mixtures requiring a high degree of uniformity. They excel at breaking down particles to a very small size, improving texture and stability. Mechanism: Typically involves a high-pressure pump that forces the mixture through a small gap or a rotor-stator system to achieve homogenization. The intense mechanical action reduces the size of particles and ensures that they are evenly dispersed throughout the mixture. Shear Pump Function: Shear pumps are used to impart high shear forces to the mixture, which helps in mixing, dispersing, and emulsifying components. They are particularly effective for applications that require intense mixing and blending. Applications: Used in a wide range of industries, including food processing, chemicals, and pharmaceuticals, where intense mixing is needed to achieve desired consistency and quality. Mechanism: Shear pumps use a combination of centrifugal and shear forces to mix and blend materials. The mixture is pumped through a rotor and stator assembly, where it is subjected to high shear forces. This helps in breaking down particles, emulsifying liquids, and achieving a homogeneous mixture. Key Differences Particle Size Reduction: Inline homogenizers are specifically designed for reducing particle size and creating very fine emulsions or suspensions, while shear pumps focus more on achieving a high degree of mixing and dispersion. Pressure and Shear Forces: Homogenizers often operate at higher pressures to achieve fine homogenization, whereas shear pumps use shear forces to achieve thorough mixing and blending. Applications: Homogenizers are more specialized for applications requiring fine particle size reduction and uniformity, whereas shear pumps are versatile and suitable for various mixing applications where intense shear is beneficial. In summary, while both equipment types are used for mixing, inline homogenizers are specialized for achieving fine emulsions and reducing particle sizes, whereas shear pumps are designed for intense mixing and blending across a range of applications. #permix #shearpumps #homogenizers #blending #mixing #processengineering #pumps

What Is The Difference Between An Inline Homogenizer & A Shear Pump? An inline homogenizer and a shear pump are both used for blending and mixing, but they have different mechanisms and applications: Inline Homogenizer Function: Inline homogenizers are designed to reduce particle size and ensure a uniform distribution of components. They work by forcing the mixture through a narrow gap or nozzle at high pressure, which creates intense shear forces and turbulence. Applications: Commonly used in the food, pharmaceutical, and cosmetic industries for creating emulsions, suspensions, and other mixtures requiring a high degree of uniformity. They excel at breaking down particles to a very small size, improving texture and stability. Mechanism: Typically involves a high-pressure pump that forces the mixture through a small gap or a rotor-stator system to achieve homogenization. The intense mechanical action reduces the size of particles and ensures that they are evenly dispersed throughout the mixture. Shear Pump Function: Shear pumps are used to impart high shear forces to the mixture, which helps in mixing, dispersing, and emulsifying components. They are particularly effective for applications that require intense mixing and blending. Applications: Used in a wide range of industries, including food processing, chemicals, and pharmaceuticals, where intense mixing is needed to achieve desired consistency and quality. Mechanism: Shear pumps use a combination of centrifugal and shear forces to mix and blend materials. The mixture is pumped through a rotor and stator assembly, where it is subjected to high shear forces. This helps in breaking down particles, emulsifying liquids, and achieving a homogeneous mixture. Key Differences Particle Size Reduction: Inline homogenizers are specifically designed for reducing particle size and creating very fine emulsions or suspensions, while shear pumps focus more on achieving a high degree of mixing and dispersion. Pressure and Shear Forces: Homogenizers often operate at higher pressures to achieve fine homogenization, whereas shear pumps use shear forces to achieve thorough mixing and blending. Applications: Homogenizers are more specialized for applications requiring fine particle size reduction and uniformity, whereas shear pumps are versatile and suitable for various mixing applications where intense shear is beneficial. In summary, while both equipment types are used for mixing, inline homogenizers are specialized for achieving fine emulsions and reducing particle sizes, whereas shear pumps are designed for intense mixing and blending across a range of applications. #permix #shearpumps #homogenizers #blending #mixing #processengineering #pumps

What Is The Difference Between An Inline Homogenizer & A Shear Pump? An inline homogenizer and a shear pump are both used for blending and mixing, but they have different mechanisms and applications: Inline Homogenizer Function: Inline homogenizers are designed to reduce particle size and ensure a uniform distribution of components. They work by forcing the mixture through a narrow gap or nozzle at high pressure, which creates intense shear forces and turbulence. Applications: Commonly used in the food, pharmaceutical, and cosmetic industries for creating emulsions, suspensions, and other mixtures requiring a high degree of uniformity. They excel at breaking down particles to a very small size, improving texture and stability. Mechanism: Typically involves a high-pressure pump that forces the mixture through a small gap or a rotor-stator system to achieve homogenization. The intense mechanical action reduces the size of particles and ensures that they are evenly dispersed throughout the mixture. Shear Pump Function: Shear pumps are used to impart high shear forces to the mixture, which helps in mixing, dispersing, and emulsifying components. They are particularly effective for applications that require intense mixing and blending. Applications: Used in a wide range of industries, including food processing, chemicals, and pharmaceuticals, where intense mixing is needed to achieve desired consistency and quality. Mechanism: Shear pumps use a combination of centrifugal and shear forces to mix and blend materials. The mixture is pumped through a rotor and stator assembly, where it is subjected to high shear forces. This helps in breaking down particles, emulsifying liquids, and achieving a homogeneous mixture. Key Differences Particle Size Reduction: Inline homogenizers are specifically designed for reducing particle size and creating very fine emulsions or suspensions, while shear pumps focus more on achieving a high degree of mixing and dispersion. Pressure and Shear Forces: Homogenizers often operate at higher pressures to achieve fine homogenization, whereas shear pumps use shear forces to achieve thorough mixing and blending. Applications: Homogenizers are more specialized for applications requiring fine particle size reduction and uniformity, whereas shear pumps are versatile and suitable for various mixing applications where intense shear is beneficial. In summary, while both equipment types are used for mixing, inline homogenizers are specialized for achieving fine emulsions and reducing particle sizes, whereas shear pumps are designed for intense mixing and blending across a range of applications. #permix #shearpumps #homogenizers #blending #mixing #processengineering #pumps

What Is The Difference Between An Inline Homogenizer & A Shear Pump? An inline homogenizer and a shear pump are both used for blending and mixing, but they have different mechanisms and applications: Inline Homogenizer Function: Inline homogenizers are designed to reduce particle size and ensure a uniform distribution of components. They work by forcing the mixture through a narrow gap or nozzle at high pressure, which creates intense shear forces and turbulence. Applications: Commonly used in the food, pharmaceutical, and cosmetic industries for creating emulsions, suspensions, and other mixtures requiring a high degree of uniformity. They excel at breaking down particles to a very small size, improving texture and stability. Mechanism: Typically involves a high-pressure pump that forces the mixture through a small gap or a rotor-stator system to achieve homogenization. The intense mechanical action reduces the size of particles and ensures that they are evenly dispersed throughout the mixture. Shear Pump Function: Shear pumps are used to impart high shear forces to the mixture, which helps in mixing, dispersing, and emulsifying components. They are particularly effective for applications that require intense mixing and blending. Applications: Used in a wide range of industries, including food processing, chemicals, and pharmaceuticals, where intense mixing is needed to achieve desired consistency and quality. Mechanism: Shear pumps use a combination of centrifugal and shear forces to mix and blend materials. The mixture is pumped through a rotor and stator assembly, where it is subjected to high shear forces. This helps in breaking down particles, emulsifying liquids, and achieving a homogeneous mixture. Key Differences Particle Size Reduction: Inline homogenizers are specifically designed for reducing particle size and creating very fine emulsions or suspensions, while shear pumps focus more on achieving a high degree of mixing and dispersion. Pressure and Shear Forces: Homogenizers often operate at higher pressures to achieve fine homogenization, whereas shear pumps use shear forces to achieve thorough mixing and blending. Applications: Homogenizers are more specialized for applications requiring fine particle size reduction and uniformity, whereas shear pumps are versatile and suitable for various mixing applications where intense shear is beneficial. In summary, while both equipment types are used for mixing, inline homogenizers are specialized for achieving fine emulsions and reducing particle sizes, whereas shear pumps are designed for intense mixing and blending across a range of applications. #permix #shearpumps #homogenizers #blending #mixing #processengineering #pumps

What Is The Difference Between An Inline Homogenizer & A Shear Pump? An inline homogenizer and a shear pump are both used for blending and mixing, but they have different mechanisms and applications: Inline Homogenizer Function: Inline homogenizers are designed to reduce particle size and ensure a uniform distribution of components. They work by forcing the mixture through a narrow gap or nozzle at high pressure, which creates intense shear forces and turbulence. Applications: Commonly used in the food, pharmaceutical, and cosmetic industries for creating emulsions, suspensions, and other mixtures requiring a high degree of uniformity. They excel at breaking down particles to a very small size, improving texture and stability. Mechanism: Typically involves a high-pressure pump that forces the mixture through a small gap or a rotor-stator system to achieve homogenization. The intense mechanical action reduces the size of particles and ensures that they are evenly dispersed throughout the mixture. Shear Pump Function: Shear pumps are used to impart high shear forces to the mixture, which helps in mixing, dispersing, and emulsifying components. They are particularly effective for applications that require intense mixing and blending. Applications: Used in a wide range of industries, including food processing, chemicals, and pharmaceuticals, where intense mixing is needed to achieve desired consistency and quality. Mechanism: Shear pumps use a combination of centrifugal and shear forces to mix and blend materials. The mixture is pumped through a rotor and stator assembly, where it is subjected to high shear forces. This helps in breaking down particles, emulsifying liquids, and achieving a homogeneous mixture. Key Differences Particle Size Reduction: Inline homogenizers are specifically designed for reducing particle size and creating very fine emulsions or suspensions, while shear pumps focus more on achieving a high degree of mixing and dispersion. Pressure and Shear Forces: Homogenizers often operate at higher pressures to achieve fine homogenization, whereas shear pumps use shear forces to achieve thorough mixing and blending. Applications: Homogenizers are more specialized for applications requiring fine particle size reduction and uniformity, whereas shear pumps are versatile and suitable for various mixing applications where intense shear is beneficial. In summary, while both equipment types are used for mixing, inline homogenizers are specialized for achieving fine emulsions and reducing particle sizes, whereas shear pumps are designed for intense mixing and blending across a range of applications. #permix #shearpumps #homogenizers #blending #mixing #processengineering #pumps

What Is The Difference Between An Inline Homogenizer & A Shear Pump? An inline homogenizer and a shear pump are both used for blending and mixing, but they have different mechanisms and applications: Inline Homogenizer Function: Inline homogenizers are designed to reduce particle size and ensure a uniform distribution of components. They work by forcing the mixture through a narrow gap or nozzle at high pressure, which creates intense shear forces and turbulence. Applications: Commonly used in the food, pharmaceutical, and cosmetic industries for creating emulsions, suspensions, and other mixtures requiring a high degree of uniformity. They excel at breaking down particles to a very small size, improving texture and stability. Mechanism: Typically involves a high-pressure pump that forces the mixture through a small gap or a rotor-stator system to achieve homogenization. The intense mechanical action reduces the size of particles and ensures that they are evenly dispersed throughout the mixture. Shear Pump Function: Shear pumps are used to impart high shear forces to the mixture, which helps in mixing, dispersing, and emulsifying components. They are particularly effective for applications that require intense mixing and blending. Applications: Used in a wide range of industries, including food processing, chemicals, and pharmaceuticals, where intense mixing is needed to achieve desired consistency and quality. Mechanism: Shear pumps use a combination of centrifugal and shear forces to mix and blend materials. The mixture is pumped through a rotor and stator assembly, where it is subjected to high shear forces. This helps in breaking down particles, emulsifying liquids, and achieving a homogeneous mixture. Key Differences Particle Size Reduction: Inline homogenizers are specifically designed for reducing particle size and creating very fine emulsions or suspensions, while shear pumps focus more on achieving a high degree of mixing and dispersion. Pressure and Shear Forces: Homogenizers often operate at higher pressures to achieve fine homogenization, whereas shear pumps use shear forces to achieve thorough mixing and blending. Applications: Homogenizers are more specialized for applications requiring fine particle size reduction and uniformity, whereas shear pumps are versatile and suitable for various mixing applications where intense shear is beneficial. In summary, while both equipment types are used for mixing, inline homogenizers are specialized for achieving fine emulsions and reducing particle sizes, whereas shear pumps are designed for intense mixing and blending across a range of applications. #permix #shearpumps #homogenizers #blending #mixing #processengineering #pumps

Development and optimization of a #lyophilization cycle is a labor-intensive and re-iterative process. Several limiting factors need to be considered; in addition, the different process steps have individual requirements that need to be taken into account. Real-time monitoring of product temperatures with the Tempris GmbH system in all #freezedryer scales offers versatile possibilities for optimization of all steps of the freeze-drying process. A lyophilization cycle is limited by the critical quality attributes of the product and the performance limitations of the equipment. For the design of an optimized process, both aspects need to be considered. In addition, the critical points to consider change within the various processing steps of a #freezedrying cycle. Formulation selection is typically based not only on the stabilizing effect but also on the critical formulation temperature during freeze-drying.

#Sterilization Methods And #Selection Of #Sterile #Drugs (3) 2.2 Dry Heat Sterilization   #Dryheat sterilization is a method of killing #microorganisms by non-specifically #oxidizing #biopolymers such as #deoxyribonucleases and microorganisms at high temperatures. According to the different ways of use, dry heat sterilization equipment can be divided into continuous type and #intermittent type. For example, tunnel type sterilization oven is continuous type, which is used for the sterilization of #vials or #ampoules; while dry heat sterilization cabinet is Intermittent type, can be used for sterilization of equipment parts and metal utensils to remove heat #source.   The thermodynamic principle of dry heat sterilization is similar to that of moist heat sterilization, and the killing of microorganisms also conforms to the logarithmic principle under certain sterilization conditions.   Dry heat sterilization can be considered for high temperature-resistant #powder #chemicals, some metal equipment, oils and utensils that do not need #moisture penetration, and glass and other high-temperature resistant items, but it is not suitable for most #pharmaceuticals, #plastics and For #rubber sterilization, dry heat sterilization can also remove heat source. For example, in the production workshop of sterile pharmaceutical #injections, some appliances in the B-level and C-level clean areas can be sterilized by electric heating through a double-door dry heat sterilizer.

ME-6100 RE: New Recirculation Tank Bottom Mixer This new family of mixers ME-6100 RE further expands such an important range for our sector as we cover the mixing needs for a wide range of applications. The recirculation tank bottom mixer is a very hygienic solution for the processes of dispersion, emulsion, homogenisation and disintegration of solids in the food, cosmetic, pharmaceutical and fine chemicals industries. In contrast to other models, the ME-6100 RE high shear mixer has a head specially designed to recirculate the product, ensuring more homogenisation throughout the tank. Furthermore, thanks to its pumping capacity, no displacement pump is required for emptying or moving the product from the tank. The mixer itself fulfils this function, avoiding the need to install a positive displacement discharge pump. This characteristic is a significant benefit in terms of competitiveness, given that the price of a transfer pump impacts the skid’s total price. The ME-6100 RE has a more closed rotor-stator unit that gets completely flooded when the product passes through the head. This ensures that all the recirculated product is exposed to high shear, improving the mixing result, with particles being reduced to sizes under 100 microns. Main features: - Single mechanical seal, accessible from inside the tank. - Different easily interchangeable stator models. - Easy cleaning and sterilisation using CIP/SIP processes. - Optional double mechanical seal. <li>Fully drainable via the eccentric outlet connection. </li> Using a recirculation tank bottom mixer allows for a simpler additional agitation required by the process. For example, a recirculation mixer with an anchor agitator can be used when manufacturing emulsions, instead of choosing a more complex option such as a counter-rotating agitator. Furthermore, this model performs the process quicker than a standard bottom mixer. The new ME-6100 RE recirculation tank bottom mixer by INOXPA provides a versatile and efficient solution for a wide range of applications. It is an excellent choice for optimising production processes, increasing competitiveness and ensuring high quality results.