Jona’s Post

Off-target effects occur when siRNAs silence unintended genes, leading to misleading experimental results. Using complex siRNA pools, such as siPOOLs (30 siRNAs per target gene), minimizes off-target activity, ensuring accurate and specific phenotypic results for more reliable research. More information here: https://buff.ly/4hFYgrI #siRNA #RNAi

VectorBuilder is here to guide you through key factors related to design and optimization of vectors with multiple ORFs. Read our latest VectorAcademy article today: https://lnkd.in/gdRun9wR 🧬 Gene delivery systems allow for efficient introduction of not just one gene, but often multiple components, including a promoter, open reading frame (ORF), and marker. These systems can also be customized to meet individual experimental needs by creating vectors with multiple ORFs, multiple fused or linked reporters, and even full expression cassettes. Efficient delivery of these vectors requires careful consideration of many points, especially when using lentiviral vectors. Visit our website to learn more ways to accelerate your research: https://lnkd.in/gvgnBqjS 🔬🎓

A new engineering strategy for improving the biosynthesis of secondary metabolites in Streptomyces has been developed through the analysis of genes co-evolved with biosynthetic gene clusters Learn more here 📰 https://lnkd.in/ejb8Sm5N #biosynthesis

𝐌𝐚𝐬𝐭𝐞𝐫 𝐆𝐞𝐧𝐞 𝐄𝐝𝐢𝐭𝐢𝐧𝐠: 𝐎𝐯𝐞𝐫 80% 𝐄𝐟𝐟𝐢𝐜𝐢𝐞𝐧𝐜𝐲 𝐰𝐢𝐭𝐡 𝐎𝐧𝐞 𝐊𝐢𝐭 Unlock new possibilities in gene editing with EditCo Bio's CRISPR Gene Knockout Kit. Designed for precision and simplicity, our kit helps you achieve 𝐨𝐯𝐞𝐫 80% 𝐤𝐧𝐨𝐜𝐤𝐨𝐮𝐭 𝐞𝐟𝐟𝐢𝐜𝐢𝐞𝐧𝐜𝐲 on your first attempt, streamlining your research without the complexity. Whether you're working with human or mouse cells, our kit is tailored to support your scientific exploration with reliable and reproducible results. Let's push the boundaries of what's possible together. 𝐎𝐫𝐝𝐞𝐫 𝐲𝐨𝐮𝐫 𝐤𝐢𝐭 𝐧𝐨𝐰: 👉 https://lnkd.in/eBe_DP4u 👈 #CRISPR #GeneEditing #Biotech #Research #Science #GeneKnockoutKit

Here @ Sonny's BBQ on Inwood for the The University of Texas Southwestern Medical School Vendor Show! Come get some lunch & chat with our gene synthesis specialist Sofija Markovic and I about your omics needs and how we can support! #genesynthesis #ngs #geneexpression #multiomics #omicssolutions

Maybe a little late. But yeah, so so happy that the preprint is out. DNA has been used outside of the genetic context. It has really exciting properties making it a great engineering material. DNA-based "reactions offer a programmable method to detect diseases. The programming however has been challenging. What does this work mean? We have simplified the "programming" aspect. An assay for a new disease, new target could be developed by simply exchanging domains. What has otherwise been a master's or PhD thesis could be achieved by a simple swap. Plug-and-play. The performance remains the same. How did it happen? Some DNA magic. Hidden in the paper. Please do give it a read, and let me know for more discussions, debates, anything.

Have you checked out the FeRGI website yet? Did you also see the database with all the genes listed - be sure to bookmark this page for easy reference when checking your genes. Or maybe you found a new gene, then be sure to share it with the team for review using the variant submission form, which can also be found on the website. 👉 https://lnkd.in/eHFtEVXh #FeRGI #ESHRE #SIGRG

1:4:6:4:1 Phenotypic ratio explained Additive genetic effects are the contributions to the final phenotype from more than one gene, or from alleles of a single gene (in heterozygotes), that combine in such a way that the sum of their effects in unison is equal to the sum of their effects individually. Genetic effects that are not additive involve dominance (of alleles at a single locus) or epistasis (of alleles at more different loci). Youtube video: https://lnkd.in/dzdcrXdX #nikolaysgeneticslessons

Alleles, hybrids, genotypes, homozygosity, heterozygosity explained An allele is one of two, or more, forms of a given gene variant. For example, the ABO blood grouping is controlled by the ABO gene, which has six common alleles. Nearly every living human's phenotype for the ABO gene is some combination of just these six alleles. Youtube video: https://lnkd.in/dYBx8cGj #nikolaysgeneticslessons

In Ovo micro-electroporation that can help understand auditory sensory development, including how the spatial and temporal patterns of sensor progenitor proliferation and hair cell differentiation are coordinated. Evsen L, Doetzlhofer A. Gene Transfer into the Chicken Auditory Organ by In Ovo Micro-electroporation. J Vis Exp. 2016 Apr 17;(110):53864. doi: 10.3791/53864. PMID: 27167684; PMCID: PMC4941936.