JIM - Journal of Internal Medicine’s Post

The typical Western diet, consisting of many UPFs (Ultra Processed Foods) cause inflammatory responses in the human body. High levels of inflammation have been shown to support the development of colorectal cancer. An anti-inflammatory approach through diet could help slow down the progression of colorectal cancer. See article below for more details. #health #healthnews #healthblog #medical #medicalnews #lifestyle #diet #newblogpost #digitalhealth #publichealth. https://lnkd.in/eMamT-Kq

I’m excited to share that our review article in Nature Reviews Cancer is now online! Here, we explore how metabolic disorders like obesity, fatty liver disease, and type 2 diabetes not only alter the immune system—leading to chronic inflammation—but also increase the risk of developing various cancers, particularly in the gastrointestinal tract. The review dissects the roles of macrophages and T cells in these conditions, and how their altered functions can regulate oncogenesis. Additionally, I discuss therapeutic approaches, such as diets, metformin, statins, and GLP1-R agonists, which not only treat metabolic disorders but also show potential in modulating cancer and immune responses. Understanding the mechanisms linking metabolic disorders and cancer could open up new avenues for tackling these interconnected epidemics. A huge thank you to leila akkari for her invaluable supervision and input, and to Daan Kloosterman for creating such fantastic figures! I deeply appreciate your contributions and all the insightful discussions we had throughout the process of crafting this manuscript! Enjoy the read! #Macrophage #Tcell #Cancer #Obesity #MASH #Diabetes #Metabolism #TumorMicroenvironment

🚨 Study Highlights the Link Between Insulin Resistance and Breast Cancer Risk 🚨 A recent study examining postmenopausal women found 58 genetic markers linked to insulin resistance (IR), and 29 of those were also associated with an increased risk of breast cancer. Lifestyle factors, such as obesity and physical inactivity, play a significant role in amplifying this risk. https://lnkd.in/gNhXw2-F Insulin resistance occurs when the body does not respond effectively to insulin, leading to blood sugar management issues. It's often caused by poor diet, lack of exercise, and excess weight. Importantly, IR is reversible with targeted lifestyle changes. Having reversed my own insulin resistance, which helped me overcome type 2 diabetes, I’m passionate about sharing what worked for me. If you're interested, explore my previous posts for insights on reversing IR. #303bbq #thehealthypitmaster #insulinresistance #breastcancerawareness #healthylifestyle #genetics

#Macrophages & #Tcells in #Metabolic #Disorder-Associated #Cancers | Breaking Expert Treatise by Daniel Taranto et al at Nature Reviews Cancer | Cancer and metabolic disorders have emerged as major global health challenges, reaching epidemic levels in recent decades. Often viewed as separate issues, metabolic disorders are shown by mounting evidence to heighten cancer risk and incidence. The intricacies underlying this connection are still being unraveled and encompass a complex interplay between metabolites, cancer cells and immune cells within the tumour microenvironment (TME). Here*, Daniel Taranto, Daan Kloosterman & leila akkari outline the interplay between metabolic and immune cell dysfunction in the context of three highly prevalent metabolic disorders, namely obesity; two associated liver diseases, metabolic dysfunction-associated steatotic liver disease (MASLD) & metabolic dysfunction-associated steatohepatitis (MASH); & type 2 diabetes. The authors focus primarily on macrophages and T cells, the critical roles of which in dictating inflammatory response and immune surveillance in metabolic disorder-associated cancers are widely reported. Moreover, considering the ever-increasing number of patients prescribed with metabolism disorder-altering drugs and diets in recent years, they discuss how these therapies modulate systemic and local immune phenotypes, consequently impacting cancer malignancy. Collectively, unraveling the determinants of metabolic disorder-associated immune landscape and their role in fuelling cancer malignancy will provide a framework essential to therapeutically address these highly prevalent diseases. *https://lnkd.in/efVKWiJK Celentyx Ltd Professor Nicholas Barnes PhD, FBPhS Omar Qureshi Catherine Brady FIGURE | Metabolic disorders increase cancer development through metabolite imbalances |

A phenome-wide association study involving 361,021 individuals from the UK Biobank revealed associations of MASLD with 948 unique clinical outcomes. Metabolic dysfunction-associated steatotic liver disease (MASLD) leads to multisystem impairments, with sequential comorbidities observed in circulatory, metabolic, and inflammatory diseases. Genetic data support links between MASLD and liver, metabolic, and cardio-cerebrovascular diseases. #MASLD #metabolicdysfunction #steatoticliverdisease #multisystemimpairments #comorbidities https://lnkd.in/eCrDpyS8

A butyrate component with fewer side effects may alleviate #autoimmunity and possible other gut barrier related disorders (#Leaky_Gut) NOTES': - Oral bioavailability of #Butyrate can be increased by esterifying it to #Serine, an amino acid transporter that aids the escape of the resulting odourless and tasteless prodrug (#O_butyryl_L_Serine, which we named #SerBut) from the gut, enhancing its systemic uptake. - In mice with #Collagen-antibody-induced arthritis (a model of #Rheumatoid_Arthritis) and with experimental autoimmune encephalomyelitis (a model of #Multiple_Sclerosis) > SerBut substantially ameliorated disease severity, modulated key immune cell populations systemically and in disease-associated tissues, and reduced inflammatory responses without compromising the global immune response to vaccination. MyNote: This might be a suitable butyrate replacement that may be used also for several other leaky gut related conditions. https://lnkd.in/eV_hsAnB

#cardiovascular #heartdisease #cardiology #medicine #medicalsciences #healthcare https://lnkd.in/geHTXWTX Abstract Cardiovascular disease (CVD) and #cancer are among the leading causes of morbidity and mortality globally, and these conditions are increasingly recognized to be fundamentally interconnected. In this Review, we present the current #epidemiological #data for each of the modifiable #risk factors shared by the two diseases, including hypertension, hyperlipidaemia, diabetes mellitus, obesity, smoking, diet, physical activity and the social determinants of health. We then review the epidemiological data demonstrating the increased risk of CVD in patients with cancer, as well as the increased risk of cancer in patients with CVD. We also discuss the shared mechanisms implicated in the development of these conditions, highlighting their inherent bidirectional relationship. We conclude with a perspective on future research directions for the field of cardio-oncology to advance the care of patients with CVD and cancer.

Esophageal Cancer: Unveiling the Silent Threat 🚨 Esophageal cancer often lurks in silence, undetected until it reaches advanced stages. 🔍 Understanding the Risk Factors: 1. Tobacco and alcohol use. 2. Gastroesophageal reflux disease (GERD). 3. Obesity. 4. Poor diet lacking in fruits and vegetables. 5. Age (more common in people over 50). 6. Genetics and family history. 🔊 Early Detection Saves Lives: 1. Persistent difficulty swallowing. 2. Unexplained weight loss. 3. Chest pain or pressure. 4. Chronic cough. 5. Heartburn or indigestion that doesn't improve with medication. 👨⚕️ Importance of Screening: Regular screenings, especially for individuals with risk factors, can lead to early detection and improved treatment outcomes. Let's encourage proactive health measures and spread awareness about the importance of screening for esophageal cancer. 💪 Together, we can make a difference in the fight against esophageal cancer. #esophagealcancer #cancerawareness #earlydetection #healthcare #wellness #screening #awarenesscampaign https://lnkd.in/gK6uVGyk

New research uncovers surprising insights into the gut microbiome! 🦠💡 Recent findings indicate that fluctuations in gut microbial load, rather than specific bacteria, may be the primary factor driving many gastrointestinal diseases. This breakthrough challenges traditional beliefs about the origins of conditions like inflammatory bowel disease (IBD) and colorectal cancer. Explore the full article to discover how these insights could reshape our understanding of gut health and disease: https://lnkd.in/eP8qSAwT

📢 Daily Paper Sharing: Dendritic cell and co-stimulatory molecule targeted therapy for autoimmune diseases: a review of the newly implemented strategies 👥 Authors: Mazen El Jamal, Farah Shibli 🔑 Keywords: Autoimmune diseases, dendritic cells, immune tolerance, co-stimulatory molecules, #immunotherapy #autoimmune #diseases #DC 🎯 "...DCs can be manipulated ex vivo and then injected back into humans to suppress the immune response. They can also be manipulated in vivo by delivering specific molecules into the DCs. Co-stimulatory molecules that shape DCs interaction with T cells can also be targeted to suppress immunity. This review tackles the latest advances in each of the 3 presented approaches." 🔗 Read the full article: https://lnkd.in/g-eVEbcw