Preventive levofloxacin found to reduce drug-resistant TB in household contacts Two studies published yesterday in the New England Journal of Medicine show that 6 months of preventive treatment with levofloxacin in children and adults with household exposure to multidrug-resistant tuberculosis (TB) resulted in statistically non-significant reductions in TB incidence compared with placebo. But an additional analysis of individual data from the two trials, which were conducted in Vietnam and South Africa, found that preventive levofloxacin led to a much larger relative reduction in cumulative incidence of TB than was initially observed. Data from the two phase 3 randomized controlled trials have already been used by the World Health Organization (WHO) to update its recommendations for TB preventive treatment (TPT). https://lnkd.in/eHc5HxRh
