KD Pharma Group’s Post

Exciting times in SynBio - which developments and applications interest you the most?

We are pleased to announce the presentation of our research poster titled "A Comprehensive Method to Quantify Underivatized Acylcarnitines and Carnitine Intermediates Using Liquid Chromatography and Ion Funnel Triple Quadrupole" by Bianca Silva at the upcoming #IMSC2024. This poster shows a comprehensive method for acylcarnitines panel (32 analytes covering short and long-chain) using a reversed-phase chromatography without derivatization step. With this method we were able to great coverage and reproducibility. We separated the main isomers using an easy-to-implement method: no derivatization, standardized metabolomics system and no ion pairing additives. Find out more https://lnkd.in/gPFZUvAs

Here’s a straightforward and practical way to make heteroaryl substituted alkyl amines. Surprising how few methods generate this type of useful functionality. This multicomponent reaction has a broad scope in all components. Great work by Alex (now at Dr Reddy’s), Roopender (Assistant Professor at UCL) and Rachel (starting final year of PhD). Check out the paper online in Angewandte Chemie

Ever wanted to talk to the people who took continuous chromatography from an academic idea to a potential new industry standard?🧪💡 While they were visiting Bachem, we had the chance to sit down and talk with Prof. Massimo Morbidelli, Dr. Lars Aumann, and Dr. Thomas Müller-Späth.🚀 ☝ Dive into the interview for insights on innovation, what it's like to work with Bachem, and the continuous chromatography potential: https://lnkd.in/es_gx9rH #ContinuousChromatography #Peptides #Oligonucleotides

Just Published 🧬 Cyclic Ion Mobility to Characterize Modified Oligos ⁉Have you seen this? What happens when teams led by Professor David Clemmer of Indiana University Bloomington and Todd Maloney from Eli Lilly and Company collaborate? They apply ion mobility to tease apart new molecular details of pharmaceutically relevant samples, of course. 📑 "Diastereomer Characterization of PS-Modified Synthetic Oligonucleotides Using Cyclic IMS-MS" Check it out for yourself: https://lnkd.in/ggffFVvx Highlights: - Direct analysis of intact phosphorothioate (PS)-modified oligonucleotides - Resolution of diastereomer information from the combination of tandem MS and tandem IMS - New analytical options to better understand structure-function/pharmacological properties Authors: Edie Sharon, Sarah O’Keefe, Kathleen Grassmyer, Shannon Raab, Ph.D., Todd Maloney, and David Clemmer #Oligonucleotides #MassSpectrometry #IonMobility #AnalyticalChemistry #ASOs #siRNA

Exciting News from Amide Technologies! As we gear up for a dynamic week with two major conferences (#PEGS and #TIDES) right here in Boston, we're thrilled to showcase our cutting-edge capabilities in peptide synthesis, pioneered at MIT and refined in the heart of Kendall Square.    What We Offer: ·      Rapid, High-Fidelity Flow-Based Synthesis: From milligrams to grams, expect expedited delivery within just 4 weeks. ·      Long Peptides: Specializing in peptides up to 120 amino acids, including complex ubiquitin variants. ·      Advanced Modifications: Our expertise extends to branched peptides, complex structures, and post-translational modifications—think dyes, biotins, pegs, and acetyl groups. ·      Hydrophobic Long Peptides: Tailored for specialized research needs, innovating in life sciences. ·      GPCR Multi-Agonists: Expertly designed to target GPCR pathways with multimeric flow synthesis, enhancing receptor activation for groundbreaking research.   Special Highlights: Kyuto Tashiro, Researcher at Amide Technologies, will be presenting a poster at #PEGS. Don't miss this opportunity to dive deep into our latest research! Mark Simon (mark@amidetech.com), CEO of Amide Technologies, will be attending both #PEGS and #TIDES, eager to connect with fellow innovators and discuss future collaborations. Located conveniently near the conference venues in vibrant Kendall Square, we invite attendees to learn more about how Amide Technologies can support your research and development projects with unparalleled precision and speed.    Visit us at www.AmideTech.com   Let's innovate together—transforming challenges into opportunities with advanced peptide synthesis!   #PeptideSynthesis #FlowChemistry #PeptideTherapeutics #Biotechnology #Innovations #BostonConferences #PEGS #TIDES #AmideTechnologies

nDIA with Orbitrap Astral is a game-changer, profiling over 100 full yeast proteomes or 48 human proteomes per day, with a depth of 10,000 human protein groups. To dive deeper into how nDIA unleashes the power of proteomics, check out our paper at Nature Biotechnology!

✨ Here is something special for you! If you work with cellculture media, you know that chemically defined (di-)peptides are now commonly used to formulate more concentrated media due to their superior solubility. 💡 To find out more about how defined (di-) peptides are involved in media chemistry and can improve cell culture performance, download our scientific poster. 📊 👉 https://lnkd.in/exNqM-KZ #Evonik #biopharma #celltherapy

Challenges with Host Cell Protein Analysis? In this recent paper from scientists at Merck, they utilize the Evosep One coupled to a Bruker timsTOF Pro 2 to overcome the challenges of host cell protein (HCP) analysis. By leveraging diaPASEF, they were able to reveal the presence of more than 600 additional HCPs previously missed by DDA PASEF. In addition to improved characterization of the sample, they were able to increase throughput and eliminate carryover! Taku Tsukidate, Alyssa Stiving, Shannon Rivera, Ansuman Sahoo, Sri Madabhushi, Xuanwen Shawn Li Take a look at the full manuscript 👇 👇👇 https://lnkd.in/e4QkQSyy To learn more about the Evosep One, visit our website evosep.com or reach out to me for additional information. #Evosep, #Bruker, #Hostcellproteins, #hcp,

Check our new Nature Communications paper detailing a novel metal-free photocatalytic cross-electrophile coupling that enables C1 homologation and Csp3-Csp3 coupling. 🔗 https://lnkd.in/eQ2RE-K9 Abstract: In contemporary drug discovery, enhancing the sp3-hybridized character of molecular structures is paramount, necessitating innovative synthetic methods. Herein, we introduce a deoxygenative cross-electrophile coupling technique that pairs easily accessible carboxylic acid-derived redox-active esters with aldehyde sulfonyl hydrazones, employing Eosin Y as an organophotocatalyst under visible light irradiation. This approach serves as a versatile, metal-free C(sp3)−C(sp3) cross-coupling platform. We demonstrate its synthetic value as a safer, broadly applicable C1 homologation of carboxylic acids, offering an alternative to the traditional Arndt-Eistert reaction. Additionally, our method provides direct access to cyclic and acyclic β-arylethylamines using diverse aldehyde-derived sulfonyl hydrazones. Notably, the methodology proves to be compatible with the late-stage functionalization of peptides on solid-phase, streamlining the modification of intricate peptides without the need for exhaustive de-novo synthesis. Great collaborative work by Stefano Bonciolini, Antonio Pulcinella, Matteo Leone, Debora Schiroli, Adrián Luguera Ruiz, Andrea Sorato, Maryne, Ranganath Gopalakrishnan, Géraldine Masson, Nicola, Stefano, Maurizio, Eli Zysman-Colman, Magnus J Johansson and Timothy Noel Funding by PhotoReAct and Chair ITN! #SyntheticMethodology, #FlowChemistry, #peptide, #crosscoupling. #metalfree