There has always been a dearth of practical and efficient methods for accessing organic nitrates, which are quite famous in the pharmaceutical industry as effective donors of the signaling molecule nitric oxide, exemplified by well-known drugs such as glycerol trinitrate and isosorbide mononitrate. A new study reports practical and regioselective halonitrooxylation of a wide variety of unactivated olefins to access β-halonitrates. The protocol offers high efficiency, mild conditions, simple operation, and good compatibility with various functional groups. Especially, the product of ethylene iodonitrooxylation, 2-iodoethyl nitrate, can be combined with a range of natural products and drugs to obtain corresponding nitrooxylated functional molecules. The potential utility of the method is further highlighted by the gram-scale preparation and late-stage modification of bioactive molecules. https://lnkd.in/gYPNw-fj
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The Impact of Glycerol on an Affibody Conformation and Its Correlation to Chemical Degradation The addition of glycerol to protein solutions is often used to hinder the aggregation and denaturation of proteins. However, it is not a generalised practice against chemical degradation reactions. The chemical degradation of proteins, such as deamidation and isomerisation, is an important deteriorative mechanism that leads to a loss of functionality of pharmaceutical proteins. Here, the influence of glycerol on the chemical degradation of a protein and its correlation to glycerol-induced conformational changes is presented. https://lnkd.in/dDwWvMhw
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Runyu Product Show-234 Cas No.: 528565-79-9 MF:C34H36P2 Abbreviation: Full Name:(-)-1,2-BIS((2R,5R)-2,5-DIPHENYLPHOSPHOLANO)ETHANE Purity:99% Runyu mainly focus on four parts: 1. Phosphine Ligands; 2. Nucleotide reagents; 3. Pd- Catslyst; 4. Constrained-geometry Catalyst (CGC). Runyu is manufacture with R&D ： ---ISO 9001:2008 Certified ---100% succeed Onsite/online audit since 2017 ---One research center + two large-scale production workshops ---Supply stable and continuously If interested in, welcome to contact with us: E-mail: yi.ding@runvmat.com #phos #drugdiscovery #cro #cdmo #crdmo #pharma #catalyst #lifesciences #biotech #Runyu #API #drugdevelopment #pharmaceuticalindustry #pharmaceutical #pharmaindustry
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Harnessing strain-release driven reactivity of a chiral SuFEx reagent: Stereocontrolled access to sulfinamides, sulfonimidamides, and sulfoximines. The amine exchange can be done at either the S(IV) or S(VI) oxidation state, leading to diverse chemical space suitable for pharmaceuticals and organocatalysts. Over 70 examples highlight the broad functional group tolerance with an emphasis on complex pharmaceutical amines. Highly functionalized sulfonimidoyl ureas from a common precursor. https://lnkd.in/gfRKY-cz
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🔬 Dive into the world of chemistry and its applications in combating potentially harmful compounds with the #article titled "Assessment of a Diverse Array of Nitrite Scavengers in Solution and Solid State: A Study of Inhibitory Effect on the Formation of Alkyl-Aryl and Dialkyl N-Nitrosamine Derivatives", authored by Prof. Dr. Zdenko Časar from Lek Pharmaceuticals, et al.🧪🌟 🔗 https://lnkd.in/dHVVABH7 #openaccess ##NitriteScavengers #Nitrosamine
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Runyu Product Show-167 Cas No.: 2021255-91-2 Abbreviation: QPhos Pd G3 Full Name: Methanesulfonate[1,2,3,4,5-Pentaphenyl-1′-(di-tert-butylphosphino)ferrocene](2'-amino-1,1'-biphenyl-2-yl)palladium(II) Purity: 98% Runyu mainly focus on four parts: 1. Phosphine Ligands; 2. Nucleotide reagents; 3. Pd- Catslyst; 4. Constrained-geometry Catalyst (CGC). Runyu is manufacture with R&D ： ---ISO 9001:2008 Certified ---100% succeed Onsite/online audit since 2017 ---One research center + two large-scale production workshops ---Supply stable and continuously If interested in, welcome to contact with us: E-mail: yi.ding@runvmat.com #QphosPdG3 #drugdiscovery #cro #cdmo #crdmo #CMO #pharmaceutical #pharma #catalyst #lifesciences #biotech #Runyu #API #drugdevelopment #pharmaceuticalindustry #pharmaceutical #pharmaindustry
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https://lnkd.in/djRaWixR The study introduces a novel strategy for synthesizing sulfonamides, essential bioisosteres of amides, by merging carboxylic acids and amines, the most common coupling partners in the pharmaceutical industry. This innovative method utilizes copper ligand-to-metal charge transfer (LMCT) to convert aromatic acids into sulfonyl chlorides, followed by one-pot amination to yield sulfonamides. Notably, this approach does not require prefunctionalization of the native acid or amine and applies to a wide range of substrates. Additionally, the strategy is extended to the synthesis of (hetero)aryl sulfonyl fluorides, offering versatility for chemical probe development and programmable bifunctional reagents. The study demonstrates the practical application of these protocols in pharmaceutical analogue synthesis, highlighting their potential significance in drug discovery and development.
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Runyu Product Show-266 Cas No.:1375325-71-5 Abbreviation:P(t-Bu)3 Pd G2 MF:C24H37ClNPPd Full Name: Chloro[(tri-tert-butylphosphine)-2-(2-aMinobiphenyl)]palladiuM(II) Purity: 98% Runyu mainly focus on four parts: 1. Phosphine Ligands; 2. Nucleotide reagents; 3. Pd- Catslyst; 4. Constrained-geometry Catalyst (CGC). Runyu is manufacture with R&D ： ---ISO 9001:2008 Certified ---100% succeed Onsite/online audit since 2017 ---One research center + two large-scale production workshops ---Supply stable and continuously If interested in, welcome to contact with us: E-mail: yi.ding@runvmat.com #P(t-Bu)3 Pd G2 #drugdiscovery #cro #cdmo #crdmo #CMO #pharmaceutical #pharma #catalyst #lifesciences #biotech #Runyu #API #drugdevelopment #pharmaceuticalindustry #pharmaceutical #pharmaindustry
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Runyu Product Show-270 Cas No.:1375325-71-5 Abbreviation:P(t-Bu)3 Pd G2 MF:C24H37ClNPPd Full Name: Chloro[(tri-tert-butylphosphine)-2-(2-aMinobiphenyl)]palladiuM(II) Purity: 98% Runyu mainly focus on four parts: 1. Phosphine Ligands; 2. Nucleotide reagents; 3. Pd- Catslyst; 4. Constrained-geometry Catalyst (CGC). Runyu is manufacture with R&D ： ---ISO 9001:2008 Certified ---100% succeed Onsite/online audit since 2017 ---One research center + two large-scale production workshops ---Supply stable and continuously If interested in, welcome to contact with us: E-mail: yi.ding@runvmat.com #P(t-Bu)3 Pd G2 #drugdiscovery #cro #cdmo #crdmo #CMO #pharmaceutical #pharma #catalyst #lifesciences #biotech #Runyu #API #drugdevelopment #pharmaceuticalindustry #pharmaceutical #pharmaindustry
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Runyu Product Show-273 Cas No.: 1375325-64-6 Abbreviation: SPHOS PD G2 MF: C38H45ClNO2PPd Full Name: Chloro(2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl)[2-(2'-amino-1,1'-biphenyl)]palladium(II) Purity: 98% Runyu mainly focus on four parts: 1. Phosphine Ligands; 2. Nucleotide reagents; 3. Pd- Catslyst; 4. Constrained-geometry Catalyst (CGC). Runyu is manufacture with R&D ： ---ISO 9001:2008 Certified ---100% succeed Onsite/online audit since 2017 ---One research center + two large-scale production workshops ---Supply stable and continuously If interested in, welcome to contact with us: E-mail: yi.ding@runvmat.com #SphosPdG2 #drugdiscovery #cro #crdmo #CMO #pharmaceutical #pharma #catalyst #lifesciences #biotech #Runyu #API #drugdevelopment #pharmaceuticalindustry #pharmaceutical #pharmaindustry
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Runyu Product Show-230 Cas No.:1375325-71-5 Abbreviation:P(t-Bu)3 Pd G2 MF:C24H37ClNPPd Full Name: Chloro[(tri-tert-butylphosphine)-2-(2-aMinobiphenyl)]palladiuM(II) Purity: 98% Runyu mainly focus on four parts: 1. Phosphine Ligands; 2. Nucleotide reagents; 3. Pd- Catslyst; 4. Constrained-geometry Catalyst (CGC). Runyu is manufacture with R&D ： ---ISO 9001:2008 Certified ---100% succeed Onsite/online audit since 2017 ---One research center + two large-scale production workshops ---Supply stable and continuously If interested in, welcome to contact with us: E-mail: yi.ding@runvmat.com #P(t-Bu)3 Pd G2 #drugdiscovery #cro #cdmo #crdmo #CMO #pharmaceutical #pharma #catalyst #lifesciences #biotech #Runyu #API #drugdevelopment #pharmaceuticalindustry #pharmaceutical #pharmaindustry
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