Laboratory Supply Network’s Post

Looking to optimize your #cannabis product formulation? Have you considered optimizing your #homogenization process? If not, you should! For a free, publicly available guide to cannabis homogenization, check out https://ow.ly/fYFH50QkJlQ It talks about why homogenization is a process that should be optimized when creating cannabis products, factors to consider when choosing a homogenizer for cannabis applications, and the pros and cons of common homogenizer types for use in cannabinoid-infused product development.

🔎 Check this out .. get this question a lot... R&D product about Below you see the before and after of going from a THC-A live rosin extract at room temperature to an activated or decarboxylated D9-THC "live" rosin extract at room temperature. The activation occurs admittedly over a long process at extremely low temperatures in closed systems, ensuring terpene loss is non-relevant and making the extract flow runny even at room temperature! The purpose here is to demonstrate the nature of true full-spectrum extracts that possess highly therapeutic compounds. This extract can replace decarboxylated ethanol extracts that are bitter and have lost some terpenes through the processing. For that matter, it can also replace distillate for inhalation, oral, or manufacturing gummies. "Why would you want to come in with so many solventless high-quality extracts at the same price as your distillates - surely that can't be good for you guys taking market share from your ethanol lines?" - you win some, you lose some in all industries and we would rather be an innovative, in-demand, high-quality supplier and provide patients with the best possible extracts. There is a place for both - especially if the price is matched the same as our distillate strategy. We will probably look back one day and think about how we sold with conviction a product that hurt our distillate sales our "bread and butter" but at least it helps to know that this decision was about putting the best possible product out there, for patients. "Are live rosin extracts easy to work with?" - Just look at this video - room temperature is runny, which means pharmacy compounding is easier to work with, and using it in our formulations for oral formulations is easier and filling for inhalation. "Isn't this extract just for savvy cannabis users?" - I think people think this because savvy cannabis users have done the research and they know that this format is probably the most therapeutic option available. "What can solventless extracts, or rosins be used for in the medical cannabis industry and how does one use them?" - As though you were using your other extracts. There is something truly unique, and special about the therapeutic ability of these full-spectrum extracts. I am annoyed I only got the conviction about 2 years ago as 6 years ago, when the full-spectrum debates were happening, this crossed our minds but hadn't scientifically gone into it - now the data is impossible to ignore. There is a lot of intellectual stimulation around quantifying these extracts besides just the terpene and cannabinoid levels. Pictured below 🌿Cultivar: Platinum Slurricane 🫧Fraction: 160 - 45 micron 🌞Conditions: Sun grown, greenhouse, full flower inputs only, not sacrificing on trim or popcorn inputs

𝗘𝘃𝗮𝗹𝘂𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝗮 𝗻𝗲𝘄 𝗱𝗶𝘀𝗶𝗻𝘁𝗲𝗴𝗿𝗮𝗻𝘁 𝗺𝗶𝘅𝘁𝘂𝗿𝗲 𝗳𝗿𝗼𝗺 𝗻𝗮𝘁𝘂𝗿𝗮𝗹 𝗿𝗲𝘀𝗼𝘂𝗿𝗰𝗲𝘀 Tablet disintegration is most often required to divide a tablet into suitably small sub-units that facilitate achievement of the desired drug dissolution rate. While semi-synthetic or synthetic super-disintegrants are commonly the materials of choice in the pharmaceutical world, there is a strong demand for options of more natural origin for nutraceutical applications. Currently only few natural disintegrants are available and these sometimes do not achieve optimum disintegration due to lack of disintegrant action. To provide satisfactory disintegrant action one or more disintegration mechanisms can be facilitated. Swelling and wicking are usually considered the main drivers in tablet disintegration while strain recovery, dissolution mechanisms and the addition of surfactants are also reported to provide some disintegrative action. Enabling synergistic effects of materials assisting swelling and wicking effects a mixture of natural materials (containing gellan gum, potato fiber, cellulose powder and natural potato starch) was optimized regarding the disintegration of various tablet formulations. The work presented here shows the disintegrant effect of this natural disintegrant mixture (CompactCel® DIS) in comparison to the disintegrant effect of a selection of natural disintegrant materials on their own (two types of starch and two types of cellulose). Continue reading here: https://lnkd.in/emhChyqm #excipients #disintegrant #tableting

Did you know that pulsating liquid flow can make or break the efficiency of pharmaceutical manufacturing processes? 🧪 Sanovaskale Technologies, under the guidance of Dr Smita Kale, has tackled the challenges of process chromatography head-on By integrating advanced seal-less diaphragm pumps, they've achieved smooth, pulse-less flow—crucial for handling fragile and expensive products with precision This innovation enhances accuracy, reduces maintenance, and scales efficiently without the need for costly dampeners 🤔 How do you think such technological advancements will shape the future of pharma manufacturing? 👉 https://lnkd.in/eRYs2vgn #Manufacturing #Efficiency #ManufacturingNews #Procurement #Defence #SupplyChain #DefenceNews #NetZero

Agile Smart Health Technology #Crocin #Saffron extract #Heabal extract #Berberine #Corcumin #Thymol #Menthol #Concrete #Absolute #Nanoencapsulation #Formulation #APIs #Pharmaceutical #Functional food

𝗢𝗽𝘁𝗶𝗺𝗶𝘇𝗶𝗻𝗴 𝗦𝗼𝗳𝘁𝗴𝗲𝗹 𝗙𝗶𝗹𝗹 𝗙𝗼𝗿𝗺𝘂𝗹𝗮𝘁𝗶𝗼𝗻: 𝗞𝗲𝘆 𝗖𝗼𝗻𝘀𝗶𝗱𝗲𝗿𝗮𝘁𝗶𝗼𝗻𝘀 Softgel capsules are a popular dosage form for pharmaceuticals and supplements, offering benefits like improved bioavailability and ease of swallowing. However, creating effective softgel formulations, especially for suspensions (pastes), involves complex considerations. This article by Vitor Jacó Antraco explores these considerations, providing insights into the science and real-world applications of softgel fills. Continue reading here: https://lnkd.in/eM2_k9TU

𝗘𝘃𝗮𝗹𝘂𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝗧𝗼𝗽𝗶𝗰𝗮𝗹 𝗔𝗻𝘁𝗶-𝗜𝗻𝗳𝗹𝗮𝗺𝗺𝗮𝘁𝗼𝗿𝘆 𝗣𝗼𝘁𝗲𝗻𝘁𝗶𝗮𝗹 𝗼𝗳 𝗠𝗲𝗻𝘁𝗵𝗮 𝗽𝗶𝗽𝗲𝗿𝗶𝘁𝗮 𝗟. 𝗘𝘅𝘁𝗿𝗮𝗰𝘁 𝗯𝘆 𝗙𝗼𝗿𝗺𝘂𝗹𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝗠𝗶𝗰𝗿𝗼𝗲𝗺𝘂𝗹𝗴𝗲𝗹 The present study is designed to develop a novel dosage form i.e. microemulgel which will enhance the rate of absorption in the systemic circulation and ultimately enhance the pharmacological effect of the Mentha piperita L. extract as anti-inflammatory agent. Its primary components include with constituents including menthol (46.32%), menthofuran (13.18%), menthyl acetate (12.10%), menthone (7.42%) and 1,8-cineole (6.06%). #pharmaceutical #formulation #microemulgel

The advent of drug discovery and high throughput screening efforts in the last decade have resulted in new chemical entities (NCEs) with low aqueous solubility and permeability (BCS class II or class IV). A softgel formulation can offer unique advantages in improving the oral absorption of such poorly soluble compounds. However, creating a robust shell matrix that is compatible with the fill material is critical to ensure efficient encapsulation, protection and achieve required drug release properties. To learn more, visit my blogpost at https://lnkd.in/gSXVSdKc Quadra | Pharmaceuticals & Supplements #Tereos #Quadra #Formulation #drugdelivery #softgels #drugdiscovery #bioavailability #Pharmaceuticals

🚀 Exciting Research Alert! 🚀 I'm thrilled to share a recent article on the Formulation Development and Evaluation of Cannabidiol Hot-Melt Extruded Solid Self-Emulsifying Drug Delivery System for Oral Applications, featuring Gattefosse's innovative surfactant Gelucire 59/14. If you have any questions or would like samples from Gattefosse after reviewing the article, please don't hesitate to reach out. #Cannabidiol #DrugDelivery #FormulationScience #Pharmaceuticals #Innovation #Gattefosse #Gelucire #Excipients #SEDDs #Lipids

𝗢𝗽𝘁𝗶𝗺𝗶𝘇𝗶𝗻𝗴 𝗦𝗼𝗳𝘁𝗴𝗲𝗹 𝗙𝗶𝗹𝗹 𝗙𝗼𝗿𝗺𝘂𝗹𝗮𝘁𝗶𝗼𝗻: 𝗞𝗲𝘆 𝗖𝗼𝗻𝘀𝗶𝗱𝗲𝗿𝗮𝘁𝗶𝗼𝗻𝘀 by Vitor Jacó Antraco Softgel capsules are a popular dosage form for pharmaceuticals and supplements, offering benefits like improved bioavailability and ease of swallowing. However, creating effective softgel formulations, especially for suspensions (pastes), involves complex considerations. This article explores these considerations, providing insights into the science and real-world applications of softgel fills. #softgel #capsules