Labroots’ Post

Every cancer is unique, requiring precise models for effective treatment development. Our solution? #Rastrum provides the tools to model complex biology in your cancer research: 🔬 Replicate Microenvironments: Customize conditions to mimic specific tissue and cellular environments, aiding in the study of cancer cell behaviors. 🔬 Enhance Drug Discovery: Investigate tumor development and cancer progression for more effective drug development. 🔬 Improve Predictability: Achieve results that closely match in vivo conditions for greater reliability and clinical relevance. 🔬 User-Friendly: An intuitive interface and efficient workflows integrate seamlessly into your processes, saving time and resources. Drive therapeutic advancements, model interactions and more with Rastrum: https://lnkd.in/g2S2CQdv

How can aligning cancer treatments with circadian rhythms improve outcomes? Ector et al. provide a high-throughput method [experimental and computational techniques] to optimize drug efficacy, paving the way for personalized medicine research. - - - Ector, C., Schmal, C., Didier, J. et al. Time-of-day effects of cancer drugs revealed by high-throughput deep phenotyping. Nat Commun 15, 7205 (2024). https://lnkd.in/dw_Nbcpn #Chronotherapy #CancerResearch #ComputationalBiomedicine - - -

From target discovery to high-throughput screening, single-cell technologies are transforming every stage of cancer drug development. 💊 🔬 Shandong University researchers highlight the critical role of single-cell technologies in advancing cancer drug discovery and development. These tools offer unprecedented insights at the cellular level, which could lead to more effective cancer therapies. Discover More: https://lnkd.in/gWs4m_CG #bioinformatics #cancer #cancerresearch #singlecelltech #drugdevelopment #scRNAseq #transcriptomics #omics #spatialomics #pharmacokinetics #CRISPR #sciencenews

🚨 Last chance to register! Join us on June 12 for an exclusive webinar tackling your spatial transcriptomics challenges and enhancing your biomarker discovery processes. https://hubs.la/Q02zZ0ht0 Dr. Nicole Kerstedt will share insights on advanced platforms that streamline research and reveal the transcriptional landscape within tumor tissues. This session will equip you with the knowledge to make informed decisions on drug treatment and pathway interactions, elevating your cancer research and therapeutic strategies. Don't miss out on this opportunity to transform your research! #Biomarkers #SpatialTranscriptomics #CancerResearch #DrugDiscovery

Shornale Akter et al. analyzed RNAseq datasets of breast cancer using computational biology approach. Analyses identified several biomarkers (e.g., hsa-miR-16-5p & FOXC1) involved in cancer cell proliferation, migration, etc., & candidate compounds that can be used as repurposed drugs. Full text: https://lnkd.in/gENB4v9a #CancerReports #Wiley #BreastCancer #Transcriptome #Datasets #Biomarkers #Bioinformatics #DrugRepurposing

Capture customized insights for #tumor genomic profiling with new Agilent Technologies SureSelect Cancer Custom panels, designed using the simple, intuitive Agilent SureDesign web portal. Tune into this webinar to learn how to design #NGS cancer assays tailored to your research goals, including the addition of new and emerging #biomarkers. https://bit.ly/4apq52y

🔬 Join Crown Bioscience for an upcoming webinar to explore how Antibody-drug conjugates (ADCs) are revolutionizing cancer treatment with improved targeting, reduced toxicity, and enhanced efficacy. 💡 Learn about cutting-edge advancements in bioconjugation technology and multi-omics approaches driving ADCs from preclinical to clinical stages. 🔍 Dr. Peng Wang, PhD, will share strategies for optimizing ADCs, overcoming resistance, and combining them with immuno-oncology therapies. ➡️ REGISTER HERE: https://buff.ly/3A9LOzt #DrugDevelopment #PrecisionMedicine #DrugDiscovery #ClinicalResearch #Oncology #OncologyDrugs #TherapeuticAreas #AntibodyDrugConjugate #PreClinical #BasicResearch

Exploring extracellular vesicles as a drug delivery system for cancer therapy: in this review article, Jiabing Lian at China Medical University and collaborators offered a comprehensive overview of extracellular vesicles, detailing their biogenesis and absorption mechanisms. Additionally, they explored current research efforts aimed at utilizing EVs as drug carriers, covering purification techniques, drug loading, and bioengineering for targeted delivery https://lnkd.in/eTCm_t4Z Their analysis highlighted the potential of EVs as versatile and effective tools for drug delivery, especially in cancer therapy. An article co-authored by Jin Wang and Bohang Yin #extracellularvesicles #exosomes #drugdelivery #cancertherapy #bioengineering #Vesiculab

Cell cycle analysis is crucial for investigating cancer therapeutics, especially to understand population heterogeneity and identify outliers with drug resistance. Livecyte combines label-free Quantitative Phase Imaging (QPI) with fluorescence to provide deep insights into cell-cycle changes. Analyse both at the population and single-cell levels to assess dry mass, growth, and time spent in each phase of the cycle. 🧬 Check out the video to see this in action 👇 #CancerResearch #CellBiology #Microscopy #DrugDiscovery #LifeSciences

ACTIVE loading of vesicles with drugs results in an intra-vesicular drug concentration significantly higher than in the loading medium. For example, the remote loading of liposomes with doxorubicin via an ammonium gradient (the prototype of ACTIVE loading) yields liposomes with drug concentrations inside the liposomes >100-fold the drug level in the loading medium. I severely doubt any of the "active drug loading" methods listed in this paper are able to achieve that. Baring a special interaction of the drug with lipid membranes or components already inside EVs, the intra-vesicular drug concentration can never be higher than in the loading medium, neither by electroporation, sonication, detergent treatment, extrusion nor by freeze-thawing cycles. All these 5 methods lack a driving force leading to an ACCUMULUATION of the drug inside the vesicle. The term "active loading" is wrongly used in this paper. I am happy to be challenged on my opinion, I am open for any discussion and if I am wrong, I would be happy to stand corrected.