Lund Stem Cell Center’s Post

The #nonCoding #RNAome offers vast, largely untapped potential for drug discovery! Check out Sophie as she explains her study on a novel lncRNA that is specific to the brain, exclusively expressed in astrocytes, and deregulated in #AlzheimersDisease. Big thanks to the team at #DZNE and our collaborator Ivana Delalle from #BostonUniversity. Watch the full video here: https://lnkd.in/eS3A9reN

Optimal micropattern dimensions enhance neurite outgrowth rates, lengths, and orientations https://t.co/Ev3wPlf4lG #EurekaMag

Latest Advancements in Understanding Alzheimer’s Disease - Global Neuroscience Horizons, IBRO-ECC edition Happening in one hour, see you there!

June is Alzheimer's, brain health and ALS awareness month 🧠 Today we are showcasing a submission from our 2024 art competition from MSc student and CLAMPS executive Lauren Joe, titled "The Brain Forest". "DAB staining of a mouse brain injected with an adeno-associated virus (AAV) that expresses eGFP-tagged S3A cofilin (a constitutively active form of cofilin). Cofilin is an actin-binding protein that affects actin dynamics in ALS. Here we can see the branches of purkinje neurons in the cerebellum. This image was captured using brightfield microscopy." 📸 Additional credit goes to the Robertson Lab. https://lnkd.in/gqvjqAKt #uoft #uoftlmp #brainhealth #ALSawareness #scienceart #gradschool #gradstudent #uoftmedicine

Did you know? Neurons act like the body’s messengers, sending signals to help us do things like walk, think, and talk. Scientists once believed we were born with all the neurons we would ever have. Mounting research shows that the growth of new neurons, called neurogenesis, is a lifelong process. Studying this process can help us understand how the birth and death of neurons play a role in brain disease. Plus, it can help scientists develop therapies that stimulate neurogenesis to reverse cognitive decline! Learn more about brain disease research we are funding here: https://lnkd.in/ginjXeRX

Hello Connections!! 💫 This is #Day33 of "Kutty Info,HUGE Knowledge Challenge!!" Header : MIT technique cracks brain's light code, unlocking secrets of brain function! Content : Researchers at MIT cracked the code for seeing hidden light within the brain using MRI! This breakthrough could revolutionize our understanding of how the brain works and pave the way for new treatments for neurological diseases. #MIT #BrainResearch #Healthcare Stay Smart,Stay Linked!! ✨

That’s a wrap on #CTAD24! GNPC’s presentation last week highlighted the progress and promise in building the largest-ever disease-specific proteomics dataset. By uniting proteomics data across neurodegeneration cohorts, establishing a framework and data sharing platform, and adding cohorts in the future, we’re well on our way to creating a better understanding of the key drivers of neurodegenerative disorders to inform better diagnosis and treatment options. Stay tuned for some big GNPC milestones: in June 2025, the harmonized dataset will be released to the research community. If you are a researcher or funder, reach out to learn how you can participate and help us shape the growth of the next cycle, set to kick off early 2025. Stay connected with the latest from GNPC throughout the year by visiting GNPC Homepage (www.neuroproteome.org) or by contacting us directly at info@neuroproteome.org. University of Tübingen Barcelona Beta UCSF Memory and Aging Center ALS TDI Banner Health Foundation & Banner Alzheimer’s Foundation Lund University Baltimore Longitudinal Study of Aging Imperial College London Maastricht University Emory Goizueta Brain Health Institute Ace Alzheimer Center Barcelona Indiana University School of Medicine University of Kansas Medical Center Washington University School of Medicine in St. Louis Mayo Clinic ANSWER ALS The Michael J. Fox Foundation for Parkinson's Research Rush University Stanford University School of Medicine University of Oxford UCL

Alzheimer's Association International Conference 2024 ✅ I am happy to share that i have got 2 abstracts accepted at the prestigious Alzheimer's Association® International Conference 2024 titled "SIMPLE FULLY CONVOLUTIONAL NETWORK TO ESTIMATE BRAIN AGE" and "SIMPLE FULLY CONVOLUTIONAL NETWORK TO DETECT ALZHEIMER'S DISEASE". We through these work propose a minimal pre-processing pipeline to perform regression on brain age and classify between Cognitively Normal (CN) and Alzheimer's Diseased (AD), the proposed modified Simple Fully Convolutional Network (SFCN) attains near SOTA results for both the mentioned task. Poster links: 1. Regression: https://lnkd.in/gUUfA_Qa 2. Classification: https://lnkd.in/gRZPUjXH #AAIC2024

Researchers have discovered a promising method to restore muscle function in a severe mouse model of ALS using a blend of grafted motor neurons and optical nerve stimulation. Read more here: https://bit.ly/3V1nCra The Ice Bucket Challenge is back, and it's not just about the chill! This global phenomenon is resurfacing to raise awareness and funds for ALS research. Join the SAICC as we embrace the icy challenge to support a cause that's making waves in the fight against ALS. Everybody knows the Ice Bucket Challenge. And now, you should also know about the amazing work that @neurosense_therapeutics is doing to fight ALS, all with one tiny pill. Let's freeze out this disease together! ❄️🤝 #IceBucketChallenge https://bit.ly/3P6uIHa #StrikeOutALS #SAICCsupports #MakeASplashForACause

AI-based approaches to drug discovery won't be useful if they are expediting a flawed process. Our approach is, and always has been, to leverage AI/ML to better understand and model disease biology, and then address in vivo phenotypes using novel chemistry. We saw evidence of this working with our epilepsy program, and now are looking to expand to other areas of neurological disease. If you're at #bio2024 feel free to reach out, always happy to chat. Looking forward to a great meeting! #ai #drugdiscovery