Material Intelligence Lab’s Post

Pharmaceutical filter membranes play a vital role in sterile filtration, clarification, and purification processes. They effectively remove particulates, microorganisms, and impurities while allowing the passage of desired components. Visit us at https://lnkd.in/df6P6zYa #PharmaFilterMembranes #SterileFiltration #Clarification #Purification #PharmaceuticalProcessing #ParticleRemoval #MicrobialControl #MembraneTechnology #laboratory #materialscience #materials #m19 #materialengineering #materialtesting #materiallab #researchanddevelopment

Today’s active pharmaceutical ingredients (APIs) are increasingly complex in structure and challenging for isolation. Effective API particle engineering is playing a critical role in meeting the demands for drug substance and drug product development. Although crystallization process is desired and commonly used as final isolation step for API production, there are many practical challenges from early process development to process scale-up and implementation in the plant. Some of the challenges are inherently related to the molecular structure and/or API crystal properties, such as high solvation propensity, low chemical stability, high oiling tendency, impurity/API structure similarity, etc.. Some are related to the inherent scale-up issues of batch processing, with drastic changes in mass, heat, and momentum transfers in large batch crystallizers. At AIChE annual conference next week, I'll present in the “495 Continuous Crystallization Processes” session and share case studies when continuous crystallization offers robust processing solutions to challenging APIs that are otherwise hard to isolate and produce at large scale. I look forward to fruitful discussions and further learning. #AIChE #crystallization #continuouscrystallization #particleengineering #API #isolation

At Dr. Reddys, we are excited to share the exceptional outcome of our relentless efforts in Sugammadex API development. Our commitment to innovation and dedication to excellence have led to significant milestones that promise to revolutionise the pharmaceutical landscape. ● The outcome of our Sugammadex API development: ● Consistent API quality (Purity > 99%) and compliance with ICH1 quality ● Identified, characterised, and synthesised nearly 18 complex impurities. ● Advanced analytical tools (React IR, Raman spectroscopy, FBRM for real-time particle size analysis, etc.) and techniques used for process development. ● Innovative chromatographic purification technique adopted to achieve the highest quality (Purity >99%) ● State-of-the-art manufacturing facility designed to handle sensitive information. ● Strict facility controls in place to control the microbial load essential for sterile injectables. To understand our product better, read the white paper here: https://rb.gy/0o53yu #DrReddysXSustainability #GoodHealthCantWait #WeAreDrReddys #DrReddysAPI #ESG #Sustainability #APIPartner #Pharmaceuticals #SugammadexAPI

Pharmaceuticals that remain after #wastewater treatment are an ongoing concern, requiring precise, sensitive methods for detection and quantification.   The use of high-performance liquid #chromatography tandem mass spectrometry (HPLC-MS/MS) allows for the accurate identification of common drugs like acetaminophen, ibuprofen, and antibiotics present in complex aqueous samples. These methods offer lower solvent consumption, improved detection sensitivity, and the ability to handle intricate matrices, making them essential for environmental monitoring and pharmaceutical testing.   Explore how this technique can be applied to your own analytical needs, ensuring accurate, reliable results in the study of pharmaceutical contamination.   Curious about the instrument used for this analysis? The Axcend Focus LC® is a compact portable capillary liquid chromatograph that provides the high sensitivity and precision needed for these types of advanced applications. Read the full application note for more details: https://lnkd.in/e83iFpZm #analyticalchemistry #environmentaltesting

The Bubble Point Test evaluates membrane filter integrity by determining the minimum air pressure needed to force bubbles through pores. It ensures efficient particle retention and microbial removal, which is critical for pharmaceutical manufacturing quality and safety. Source: https://lnkd.in/d68Dn38Y Visit us at https://lnkd.in/df6P6zYa #BubblePointTest #MembraneIntegrity #ParticleRetention #MicrobialRemoval #PharmaQualitySafet #laboratory #materialscience #materials #m19 #materialengineering #materialtesting #materiallab #researchanddevelopment

The Bubble Point Test evaluates membrane filter integrity by determining the minimum air pressure needed to force bubbles through pores. It ensures efficient particle retention and microbial removal, which is critical for pharmaceutical manufacturing quality and safety. Source: https://lnkd.in/d68Dn38Y Visit us at https://lnkd.in/df6P6zYa #BubblePointTest #MembraneIntegrity #ParticleRetention #MicrobialRemoval #PharmaQualitySafet #laboratory #materialscience #materials #m19 #materialengineering #materialtesting #materiallab #researchanddevelopment

The Automated Media Dispensing System LAMD-A11 is an instrument with high precision designed to streamline media dispensing in laboratories. It offers high throughput, precise volume control, a user-friendly touchscreen, temperature regulation, and an automatic cleaning feature. This system boosts efficiency, reduces contamination risks, and saves costs by minimizing media wastage. Ideal for microbiology and pharmaceutical Laboratories, the LAMD-A11 ensures consistent and high-quality media preparation. #richflood #riskadvisory #riskmanagers #riskmanagement #certifications #inspections #SupplyChain #riskmanagementconsulting #LabInnovations2022 #CloudLIMS #LabAutomation #LIMS #LabProfessionals #DataManagement 

For measurements of your complex biological media we offer biosensors, designed for measuring the concentration of glucose, lactate, glutamine and glutamate in aqueous media. Our biosensors are built on the enzymatic-aerometric measurement principle. Find the right biosensor for your application: LV5 biosensor - suitable for sampling systems in laboratories or food and pharmaceutical industries. IV4 sensor - can be used for example in bioreactors or aseptic media. Learn more https://lnkd.in/g9ChQT73 #ADMMinn #Sensors #InnovativeSensorTechnology #TemperatureSensors #FlowSensors #ThermalMassflowSensors #ConductivitySensors #BioSensors

Why filters are needed in the process of manufacturing pharmaceutical liquids? 👉 💊 Pharmaceutical filters separate impurities and microorganisms in pharmaceutical solutions through a filter medium. The filtering medium is usually a microporous material such as filter paper, filter membrane or filter cartridge. When the medicinal liquid passes through the filter medium, the impurities and microorganisms are retained on it, while the pure medicinal liquid passes out.   💉 The main functions of the medicinal liquid filter are as follows:   1.Removal of impurities: including suspended matter, sediments and particles, etc., to ensure the purity and stability of the medicinal solution.   2.Remove microorganisms: such as bacteria, viruses and fungi, etc., to ensure the sterility and safety of the pharmaceutical solution.   3.Improve product quality: Enhance the market competitiveness and credibility of the product by improving the purity and quality of the medicinal liquid.   4.Protect equipment: prevent damage and contamination of equipment by impurities and microorganisms, prolong the service life and performance of equipment. #pharmaceutical #filter #filtration #biotech #micro #medicinal

Medical and pharmaceutical products are often packaged in fluid-filled containers. At times, such containers are subject to temperature variations that cause them to expand or contract. During such fluctuations, the containers can develop cracks or pinholes. Bacteria and other contaminants can taint the contents of the containers making them unsafe for human use. Learn about conducts container closure integrity testing (CCIT) using high voltage leak detection (HVLD), how HVLD technology works, and more. Brian Svaton, Nikka Densok USA #ccit #leaktesting #pharma #leakdetection #highvoltage #parenterals #asepticpackaging Pharmaceutical Online