M20 Genomics’ Post

🔬 Monday Molecule: #CRISPR-#Cas9 – Revolutionizing Genetic Disease Treatment #CRISPR-#Cas9 is making waves in the scientific community for its ability to edit genes with unprecedented precision, offering hope for curing genetic diseases like sickle cell anemia and muscular dystrophy. 🌱   What makes this molecule so powerful? #CRISPR-#Cas9 functions like molecular scissors, cutting DNA at specific sites to allow for targeted gene correction or modification. 🔬 This technology opens up a world of possibilities for personalized medicine, where genetic diseases could soon be treated at their source. At Certified Genetool, Inc., we provide the lab equipment that supports this groundbreaking research: - #Flow #Cytometers, like the #Attune #NXT, help researchers monitor how gene-edited cells behave and ensure precision in CRISPR edits. - #AKTA #Avant 150 purification systems assist in purifying proteins and nucleic acids critical for gene-editing work. As we move closer to a future where genetic diseases are a thing of the past, CGI is proud to support the labs making these innovations possible. 💡 Check out this publication on CRISPR-Cas9: https://lnkd.in/gXxMySDm #CRISPR #flowcytometer #purification #groundbreaking #research #nature #science

The Human Genome Project (HGP) is a landmark in science, revolutionizing our understanding of genetics. Completed in 2003, it mapped the entire human DNA sequence, identifying around 20,000-25,000 genes. This project has profound implications for medicine, enabling personalized treatments, better disease prediction, and new drug developments. It also paved the way for advances in fields like genetics, biotechnology, and anthropology, impacting everything from cancer research to understanding human evolution. The HGP's success exemplifies the power of international collaboration in science, laying the groundwork for future breakthroughs in health and disease prevention. For more information, go through the blog about "Human Genome Project". Link is below in the comment section. #biotech #biotechnology #science #research #genome #genes #health #diseases #treatment #genetics #cancer #medicine #evolution #DNA

Science is amazing! Back in 2008, we published paper #1 on a novel Nod-like receptor (NLRs) called NLRX1. https://lnkd.in/eTQBdAVx. Before this, NLRX1 was just a novel fragmented sequence in the incomplete human genome databases, but genomically it looked quite interesting, thus we set out to elucidate its function. So, as a post-doc, I worked to clone and characterize this novel gene/protein, ultimately unveiling NLRX1 function as a novel "checkpoint" on antiviral immune signaling. Fast forward, 16yrs and there are over 200 publications on NLRX1, and just yesterday, the crystal structure was reported. How many times did I sit there and wonder "how does this thing work"? In addition, there are now NLRX1 inhibitors entering the clinic for diseases such as IBD, and other auto-inflammatory indications. I haven't worked on NLRX1 since 2008, but not a day goes by that I don't search pubmed for new NLRX1 articles published by others. Science really is a community, and we often see that community as competition, but truthfully it takes a village to truly understand complex biology. I am beyond thankful to sit on the sidelines of NLRX1 biology and read each article with bated breath and smile inside as those much smarter than I uncover the complexities of a protein that has existed since before the split of the animal and plant kingdoms. https://lnkd.in/e3RWYjuF

Simply amazing to realize that even two decades after sequencing the human genome, its mysteries remain far from fully understood. The recent breakthrough in studying the “dark proteome” reveals thousands of previously overlooked genes that encode small, yet potentially powerful, miniproteins. These discoveries challenge long-held assumptions and highlight how much remains to be explored—not just within our genome, but also in how it interacts with the exposome. #HumanGenomics #Proteomics #Exposome #DarkProteome #BiomedicalResearch #EnvironmentalHealth #Innovation #HumanGenome #DrugDiscovery #PersonalizedMedicine #NIAAA #NIA #NIEHS

"Frontiers of Science"-Award for #HelmholtzMunich team! 👏Congratulations to Prof. Fabian Theis, Dr. Alexander Wolf Wolf and Philipp Angerer for their 2018 paper, “Scanpy: large-scale single-cell gene expression data analysis", published in the journal "Genome Biology". 💡The experts have been honored with the "Frontiers of Science" award at the International Congress of Basic Science (ICBS) in Beijing. Their work on #Scanpy is revolutionizing #genomics and #bioinformatics, making single-cell RNA sequencing (#scRNA-seq) data analysis faster and more accurate. 🌟 This is a game-changer for #PersonalizedMedicine and could lead to breakthroughs in understanding, diagnosing, and treating complex diseases. 👉Discover more in our news: https://lnkd.in/gtPaVhXd Frontiers #FrontiersOfScience #Genomics #Bioinformatics #ICBS2024 #AI

#OneDayOneGenome Spotlight:🦠 Pseudomonas aeruginosa A team of researchers led by Dr Bhabatosh Das at Translational Health Science and Technology Institute (THSTI) has sequenced the genome of Pseudomonas aeruginosa, an opportunistic pathogen isolated from tissue of an Indian patient. Analysis revealed its genetic features contributing to its resistance mechanisms, pathogenicity, virulence factors, AMR and presence of transferable mobile genetic elements (MGEs). MGEs are known to associate with the rapid evolution of the microbes through horizontal gene transfer and are linked with fitness traits such as antimicrobial resistance (AMR), virulence, and metabolic functions. The detailed analysis revealed presence of AMR related genes are highly heterogeneous and are associated with MGEs. Genomic analysis will help in transforming our ability to track and combat antibiotic resistance, paving the way for improved prognostic outcomes and better overall health. #AntibioticResistance #Genomics #ResearchAndDevelopment #PublicHealth #OneHealth For more information: https://lnkd.in/gvidvfXn Rajesh Gokhale BRIC-National Institute of Biomedical Genomics

The The University of Edinburgh, Action for ME and Oxford Nanopore Technologies and, supported by Edinburgh Innovations, have joined forces in a bid to in a bid to uncover the genetic causes of Myalgic encephalomyelitis (ME). Their joint project, SequenceME, builds on the DecodeME study, the world’s largest genetic study of ME led by the University of Edinburgh and Action for ME, which collected saliva samples from 17,000 participants to investigate whether common genetic variants were more likely to appear in those with ME than those without the condition. Sequence ME will use advanced whole genome sequencing technology to uncover the root causes of ME and to determine whether it is one illness, or an umbrella condition encapsulating multiple diseases. Read more➡️https://lnkd.in/eT6kAszj #innovation #collaboration #ME #mecfs

“This monumental work represents a culmination of 20 years of hard work. We finally have the complete picture of how genes are formed in higher organisms,” says Marco Mangone, a researcher in the Biodesign Virginia G. Piper Center for Personalized Diagnostics and a professor in the School of Life Sciences at Arizona State University. Mangone and ASU researchers have made a significant advance in understanding how genes are controlled in living organisms. The new study, published in the journal Nucleic Acids Research, focuses on critical snippets of RNA in the tiny, transparent roundworm Caenorhabditis elegans (C. elegans). The study provides a detailed map of the 3'UTR regions of RNA in C. elegans. 3'UTRs (untranslated regions) are segments of RNA involved in gene regulation. The new map is a valuable tool for scientists studying how DNA genes are switched on and off after they are transcribed into RNA. By studying the genetic material in this model organism, researchers are gaining deeper insights into the mysteries of gene behavior, shedding light on fundamental biological processes essential to human health and disease. Read the full story on ASU News: https://ow.ly/ybMN50SylKv #ASUResearch #RNA #Innovation #ASU

Congratulations to Garvan researchers Dr Drew Neavin and Prof Joseph Powell who have been awarded a highly competitive Data Insights Cycle 3 grant from the Chan Zuckerberg Initiative. This prestigious grant comes with funding support over 18 months for their project, SNAPSHOT: A Comprehensive Cell Atlas of Biological Variation. SNAPSHOT aims to build contextual cellular snapshots into existing cell atlases to better understand the variables contributing to gene variation in health and disease. The project will investigate how factors such as a person’s genetic background, existing health conditions, biological sex, and the specific types of cells in their body influence the way genes are expressed and vary from one individual to another. One key aspect of this investigation is examining ‘allelic ratio bias’ – the differences in the expression levels of two versions (alleles) of a gene inherited from each parent. By understanding these influences and differences, SNAPSHOT will provide a missing link between disease, genes and effective personalised therapies. #CellAtlas #GeneVariation #MedicalResearch #Innovation #PersonalisedMedicine Chan Zuckerberg Initiative

We are thrilled to be part of the ACMG - American College of Medical Genetics and Genomics 2024 conference as a member of this year's startup pavilion! At the heart of our participation is #CodeXome, our cloud platform that is redefining genetic analysis. By leveraging an evolutionary perspective, CodeXome offers unique insights into DNA variants, enabling researchers to uncover critical diagnostic markers and explore the evolutionary trajectory of genes. Our platform provides a comprehensive gene analysis, revealing each gene's history, function, and its relevance to modern medicine. 🔍 Discover CodeXome in Action Please come visit us in the startup pavilion at booth 627b for a personal demonstration of CodeXome. Our team is excited to discuss how CodeXome can accelerate your projects and uncover insights previously unreachable. 🎙️ Don’t Miss Our Poster Talk on Friday Join us for our poster presentation, “It’s About Time: How Key Genes Linked with Post-Traumatic Stress Disorder Evolve.” This session will delve into the ADCYAP1 gene and its receptor, ADCYAP1R1, showcasing the evolution of crucial components linked to stress response and neurological disorders. Our findings highlight the significance of evolutionary genomics in understanding and addressing complex diseases. 🌐 Be Part of the Evolutionary Genomics Revolution Cornerstone Genomics stands at the forefront of integrating historical and current genomic research to enhance our understanding of genetics. We are excited to meet with you to discuss how we can collaborate to push the boundaries of genetic discovery. For more information about our products and to request a free trial, you can also visit cornerstonegenomics.com. #ACMGMtg24 #ACMG24 #ACMG2024 #Genomics #CodeXome #GeneticResearch #EvolutionaryGenomics #MedicalGenetics