Governing with public engagement: an anticipatory approach to human genome editing Dorit Barlevy et al., (2024). Science and Public Policy, scae010, https://lnkd.in/eXp-35DS Abstract: In response to calls for public engagement on human genome editing (HGE), which intensified after the 2018 He Jiankui scandal that resulted in the implantation of genetically modified embryos, we detail an anticipatory approach to the governance of HGE. By soliciting multidisciplinary experts’ input on the drivers and uncertainties of HGE development, we developed a set of plausible future scenarios to ascertain publics values—specifically, their hopes and concerns regarding the novel technology and its applications. In turn, we gathered a subset of multidisciplinary experts to propose governance recommendations for HGE that incorporate identified publics’ values. These recommendations include: (1) continued participatory public engagement; (2) international harmonization and transparency of multiple governance levers such as professional and scientific societies, funders, and regulators; and (3) development of a formal whistleblower framework.
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Snipping and Stitching the Script of Life: A Deep Dive into the Ethical Maze of Gene Editing | WardenShield
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Explore the ethical maze of gene editing and CRISPR's potential to cure diseases and enhance human traits. How do we balance innovation with ethics? #GeneEditing #Bioethics #CRISPR #FutureOfMedicine #EthicalScience https://lnkd.in/d6TMvPPg
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Australia has led the way in regulating gene technology for over 20 years: Here's how it should apply that to AI.
Australia has led the way regulating gene technology for over 20 years. Here’s how it should apply that to AI
theconversation.com
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Genetic Editing: Are we playing God or Enhancing Human Life? Genetic editing, particularly with technologies like CRISPR-Cas9 (a laboratory tool used to change/"edit" pieces of a cell DNA) TALENs, Zinc Finger Nucleases (each with unique applications), allows us to make precise changes to DNA which is the very blueprint of life. It is a breakthrough that holds the potential to cure genetic diseases, enhance physical traits, and even prevent inherited conditions before a child is born. But, as exciting as this sounds, it also raises deep ethical questions - chief among them, "Are we playing God?" At its core, genetic editing challenges the natural course of human life. When we alter genes, especially in ways that can be passed down to future generations (known as germline editing. Here, the genome of an individual is edited in such a way that the change can be inherited), we are not just fixing a problem for one person—we are potentially redesigning humanity. This power to change fundamental aspects of life makes many people uneasy, as it touches on deeper moral, religious, and philosophical beliefs about the sanctity of life, human limitations, and whether there should be boundaries in science. On one hand, genetic editing can be viewed as an incredible tool for enhancing human life. It offers the possibility of eradicating devastating diseases like cystic fibrosis, sickle cell anemia, or Huntington’s disease, giving people healthier, fuller lives. It can even be used to improve agricultural yields, helping feed the world more sustainably. In this sense, are we not simply using our knowledge and abilities to better ourselves and our world? But on the other hand, when we talk about "playing God," we’re referring to the idea of overstepping human boundaries—making decisions that could have far-reaching and unintended consequences. What happens if we start editing genes not just to prevent disease, but to enhance traits like intelligence, strength, or appearance? Does this lead to a slippery slope where genetic modification becomes a tool for societal inequality or even eugenics? And, most importantly, who gets to decide what "enhancements" are acceptable? As a lawyer passionate about medical law and bioethics, these questions resonate because they extend beyond science and into regulation, human rights, and social justice. The legal frameworks around genetic editing will need to strike a balance between fostering scientific innovation and protecting individuals from exploitation or harm. No universal regulations exist, leading to a fragmented approach across countries. We will need laws that consider the potential for abuse, set ethical boundaries, and ensure that genetic editing is used in a way that enhances life without diminishing our humanity. Ultimately, this debate requires careful thought, open dialogue, and a global perspective to ensure that we harness the power of genetic editing responsibly, for the good of all.
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Revolution or Risk? The Ethical Crossroads of CRISPR Technology and Personalized Medicine CRISPR technology and personalized medicine have transformed healthcare, offering unprecedented precision and potential for treating genetic diseases. But, have we considered the ethical implications? - Permanent changes to the human genome - Exacerbating healthcare disparities - Informed consent and transparent communication - Neglecting environmental and lifestyle factors - Unintended consequences and unforeseen outcomes And, in personalized medicine: - Privacy and data security concerns - Discrimination and stigma - Resource allocation and patient autonomy - Cultural sensitivity and diverse values Let's engage in open discussions to ensure how these innovations prioritize equity, autonomy, and well-being for all. P.S: To get the Indepth knowledge of what are this ethical consideration, check out my latest article on The Ethical Crossroad of CRISPR Technology and Gene Editing. #CRISPR #PersonalizedMedicine #Ethics #HealthcareInnovation #GeneticEngineering #Bioethics
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In recent years, the emergence of #CRISPR technology has ignited a fervent debate regarding its potential implications for human society, particularly in the realm of #eugenics. #bioethics #worldnews #geneediting #genetics #science #research #news #health
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There is good reason for us not to allow for heritable human genome editing (HHGE) given where we are with the science and its technological applications. It is not ready, and many of the safety concerns experts have raised remain unanswered. There are many indications from tests on animals that HHGE is still unsafe, leads to unintended consequences, and can have off-target effects among other things. We don't have a clear understanding of how these interventions work. Those are strong reasons to hold off on any clinical applications. Even if all of those kinds of technical problems were resolved, there are still the ethical problems of this being a form of eugenics.
My latest, rather odd story, in Nature Magazine. South Africa has updated its research ethics guidelines with a section on heritable human genome editing. Some researchers say it isn't an issue 'cause such editing on patients is illegal; other say that it is allowed under the law. "“The decision to amend the South African Ethics in Health Research Guidelines to facilitate research to create genetically modified children is baffling,” says Francoise Baylis, a bioethicist at Dalhousie University in Halifax, Canada. Other words from Michael Pepper, Jantina De Vries and Bonginkosi Shozi. https://lnkd.in/e5qt5cWp
Will South Africa become first country to accept controversial form of human genome editing?
nature.com
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Rewriting Our DNA: Ethical Dilemmas in the Age of Genetic Editing Genetic testing and revolutionary technologies like CRISPR are offering new possibilities in healthcare—from curing genetic diseases to personalizing treatments based on an individual's DNA. But with these advancements come profound ethical questions. In this article, I explore how CRISPR works, its potential to prevent and cure genetic diseases, and the challenges we face in ensuring privacy, equity, and ethical oversight. The promise of genetic technology is transformative, but we must also be mindful of the risks, from unintended consequences to the potential for genetic discrimination. #GeneticEditing #CRISPR #Ethics #HealthcareInnovation #PersonalizedMedicine https://lnkd.in/d-B54pUg
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