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Antiobesity medications are prescription drugs designed to help individuals manage their weight, particularly when lifestyle changes such as diet and exercise have not been sufficient. These medications are typically recommended for adults with a Body Mass Index (BMI) of 30 or greater, or a BMI of 27 or greater if they have weight-related health conditions like type 2 diabetes or hypertension Commonly Prescribed Antiobesity Medications 1. **Semaglutide (Wegovy, Ozempic)**: A GLP-1 receptor agonist that helps reduce appetite and is administered via injection. It is approved for adults and children aged 12 and older with obesity [[1]](https://lnkd.in/g4zb65Qa). 2. **Tirzepatide (Zepbound, Mounjaro)**: This medication acts on both GLP-1 and GIP receptors to reduce appetite and is also given as an injection. It was recently approved for obesity treatment 3. **Liraglutide (Saxenda)**: Another GLP-1 receptor agonist, it is administered daily and helps increase feelings of fullness 4. **Phentermine**: One of the oldest weight loss medications, it is typically prescribed for short-term use and works as an appetite suppressant 5. **Phentermine-topiramate (Qsymia)**: A combination of phentermine and topiramate that enhances weight loss by decreasing appetite and cravings 6. **Naltrexone-bupropion (Contrave)**: This combination medication affects the brain's reward system to reduce cravings and is taken in tablet form 7. **Orlistat (Xenical, Alli)**: A lipase inhibitor that prevents the absorption of dietary fats. It is available in both prescription and over-the-counter forms 8. **Setmelanotide (Imcivree)**: Approved for individuals with specific genetic disorders that cause obesity, this medication helps manage weight by affecting appetite ### Effectiveness and Considerations - **Weight Loss**: Patients using these medications can expect to lose between 3% to 12% more of their starting body weight compared to those who rely solely on lifestyle changes. Some may achieve a loss of 10% or more, which can significantly improve health markers like blood pressure and blood sugar levels - **Side Effects**: Common side effects include nausea, constipation, and diarrhea, which may diminish over time. Serious side effects are rare but can occur, making it essential to discuss potential risks with a healthcare provider - **Long-term Use**: Many of these medications are intended for long-term use, but if a patient does not lose at least 5% of their body weight after 12 weeks, a healthcare provider may recommend discontinuing the medication or trying a different one ### Conclusion Antiobesity medications can be an effective tool for weight management, especially when combined with lifestyle changes. However, they are not suitable for everyone, and a healthcare provider's guidance is crucial in determining the best approach for individual needs.

Wegovy is now available in Canada for the treatment of obesity. Nutrition (and dietitians!) becomes even more important for people on GLP-1 drugs -- with reduced hunger, nutrient-rich choices are key to meet nutrient needs with less food. #nutritiontrends #dietitians #weightlossdrugs https://lnkd.in/gq6m4ajn

𝗗𝗘𝗖𝗘𝗠𝗕𝗘𝗥 is just around the corner 😱⚠️ And I can hardly believe how quickly this year has flown by! As I wrap up this week, I've been engaged in several challenging projects: • I #PostEdited #MarketingContent for 𝘥𝘪𝘦𝘵𝘢𝘳𝘺 𝘴𝘶𝘱𝘱𝘭𝘦𝘮𝘦𝘯𝘵𝘴, which introduced me to concepts related to qi and traditional Chinese medicine. • I #Edited an #ICF for an investigational 𝘵𝘳𝘦𝘢𝘵𝘮𝘦𝘯𝘵 involving patients with regressed #Cancer. • I #PostEdited another ICF for a 𝘥𝘳𝘶𝘨 targeting #Patients with atherosclerotic cardiovascular and chronic kidney #Disease. ▶️ These last two projects have reinforced my belief in the importance of participating in #ClinicalTrials to advance #Medicine. ⚕️ It’s been a hectic time, but I know a quieter period is on the horizon 🛣️, so I’m learning to appreciate these times of abundance 🌝. Are you ready for the weekend?  Have you worked on any challenging projects in the past few days? #Translation #Editing #MTPE #Healthcare #Health #PatientFacing #Education

Comparison of the therapeutic effects of febuxostat combined with a low-purine diet and allopurinol combined with a low-purine diet on the improvement of gout patients Comparison of Febuxostat and Allopurinol with Low-Purine Diet in Treating Gout Objective To compare the effectiveness of febuxostat with a low-purine diet versus allopurinol with a low-purine diet in treating gout. Methods A study with 98 gout patients compared the two treatments. Patients were evaluated based on joint function, serum uric acid levels, and inflammatory factors. The Numeric Rating Scale was used to assess pain. Clinical indicators before and after treatment were compared. Results After 6 months, the study group showed a higher effective rate (97.96%) compared to the control group (85.71%). The study group also had lower levels of serum uric acid, creatinine, total cholesterol, and triglycerides. Inflammatory factors and pain levels were significantly lower in the study group. The study group also had a lower incidence of adverse reactions. Conclusion Febuxostat with a low-purine diet can reduce inflammatory factors and alleviate pain in gout patients, improving their clinical symptoms significantly. Clinical trials are essential for developing safe treatments. Our AI-driven platform, DocSym, consolidates standards, protocols, and research for clinicians. Streamlining operations is crucial in healthcare, and our mobile apps support scheduling, monitoring treatments, and telemedicine to improve patient care and expand services digitally. By using AI, clinics can enhance workflows and improve patient outcomes. Learn more at aidevmd.com. https://lnkd.in/gcSanJMf #ClinicalTrials #AIinHealthcare #MedicalAI #HealthTech #DigitalHealth #PatientCareAI #AIResearch #MedicalInnovation #BioTech #AIforGood #HealthcareData #AIinMedicine #PharmaAI #ClinicalData #HealthAI #AIHealthSolutions #PrecisionMedicine #AIandHealth #ClinicalAnalytics #AIDiagnostics

The Case Against Cholesterol-Lowering Medications: Evidence-Based Reassessment By Michael Shaffer A wealth of independent peer-reviewed research, uninfluenced by pharmaceutical interests, has definitively established that cholesterol levels bear no correlation to all-cause mortality. This revelation fundamentally challenges the widespread prescription of cholesterol-lowering medications. A meta-analysis of 21 studies involving over 300,000 individuals found no association between LDL cholesterol levels and mortality risk in people over 60 years old (Ravnskov et al., 2016). Another study examining over 1.3 million individuals concluded that there is no evidence to support the notion that low cholesterol levels increase mortality risk (Kulkarni et al., 2016). Additionally, research has indicated that high total cholesterol may even be associated with reduced mortality in certain populations (Schwartz et al., 2012). The primary objective of these medications is to mitigate the risk of heart disease and stroke - leading causes of death. However, if cholesterol itself is exonerated as a causal factor in these conditions, artificially lowering it confers no tangible benefit in terms of improved health or prolonged lifespan. Furthermore, these medications are not without their drawbacks. Statins, in particular, carry a spectrum of potential side effects, including muscle damage, liver dysfunction, and an elevated risk of diabetes. When juxtaposed with the absence of a demonstrable mortality benefit, these risks become even more disconcerting. This compelling evidence necessitates a paradigm shift in our approach to cardiovascular health. Rather than relying on medications that may be unnecessary and harmful, the focus should pivot towards addressing the root causes of heart disease and chronic illness. Lifestyle interventions such as dietary modifications, exercise, stress management, and smoking cessation offer a far more promising avenue for achieving optimal health and longevity. In conclusion, the weight of independent research unequivocally challenges the conventional wisdom surrounding cholesterol's purported link to mortality. This paradigm shift calls for critical re-evaluation of the widespread use of cholesterol-lowering medications. By embracing lifestyle approaches and actual drivers of chronic disease, individuals can reclaim health and pursue a life of vitality and well-being. References: Kulkarni, H., et al. (2016). Low cholesterol and the risk of death: a systematic review and meta-analysis of 1.3 million individuals. BMJ Open, 6(9), e010401. Ravnskov, U., et al. (2016). Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review. BMJ Open, 6(6), e010401.   Schwartz, L. M., et al. (2012). High total cholesterol levels are inversely associated with mortality in 92,000 elderly patients in the United States. Journal of Clinical Lipidology, 6(6), 534-542.

Fatty Liver Disease Overview 💦 Fatty liver disease (FLD) occurs when excess fat builds up in the liver. It is broadly categorized into: Non-Alcoholic Fatty Liver Disease (NAFLD): Fat accumulation not due to alcohol. Alcoholic Fatty Liver Disease (AFLD): Fat accumulation due to excessive alcohol consumption. Symptoms Often asymptomatic, but possible symptoms include: Fatigue Abdominal discomfort Enlarged liver Risk Factors Obesity Type 2 diabetes High cholesterol Metabolic syndrome Excessive alcohol consumption (for AFLD) Diagnosis Blood tests (liver enzymes) Imaging (ultrasound, CT, MRI) Liver biopsy (for definitive diagnosis) Treatment Lifestyle Changes Diet: Low-fat, balanced diet Avoiding sugary foods and beverages Consuming plenty of fruits, vegetables, and whole grains Exercise: Regular physical activity (150-300 minutes of moderate exercise per week) Weight Loss: Gradual weight loss (7-10% of body weight) Alcohol Abstinence: For AFLD, complete cessation of alcohol intake Medications Vitamin E: For non-diabetic NAFLD patients For diabetic NAFLD patients (under medical supervision) Statins: To manage cholesterol levels Medical Monitoring Regular follow-ups with healthcare providers Monitoring liver function tests Advanced Treatments For severe cases (e.g., cirrhosis), treatments may include: Liver transplant Clinical trials for emerging therapies Prevention Maintaining a healthy weight Balanced diet and regular exercise Limiting alcohol consumption

Knowing Kidney Health: Prevention and Management of Kidney Failure 🩺💡 Methods for Preventing Kidney Failure 🛡️ 1. Control Blood Pressure and Blood Sugar 🩸 Managing renal or primary hypertension can prevent the progression of glomerulosclerosis. The former primarily involves controlling the high perfusion of the glomeruli, while the latter relies mainly on the use of antihypertensive medications. Regular monitoring of blood glucose levels is also crucial for managing diabetes, as diabetes is one of the major risk factors for renal failure. 🩺💉 2. Lower Blood Lipids 🥗 Correcting lipid metabolism disorders begins with appropriate dietary fat intake 🥑, alongside regular physical activity 🏃♀️ and appropriate caloric intake 🍽️. When necessary, lipid-lowering medications 💊 may also be employed. 3. Balanced Diet 🥦🍓 Numerous experimental studies and clinical observations indicate that a low-protein and/or low-phosphorus diet can slow the progression of chronic kidney disease (CKD) in most patients, and may even temporarily halt its advancement. A low-protein diet or the addition of essential amino acids can alleviate the hyperfiltration state associated with chronic kidney disease and help prevent its progression. 4. Stop Smoking 🚭 According to data from the World Health Organization, smoking increases the risk of hypertension and kidney cancer 🎗️. It can also interfere with the effectiveness of antihypertensive medications. Poor blood pressure control or management is a significant cause of kidney damage. Smoking reduces blood flow to vital organs, including the kidneys, potentially exacerbating kidney disease. Quitting smoking can help prevent renal failure. 🚫 5. Timely Check-Ups 🗓️ The kidneys act as our body’s "filter" ⚙️, quietly removing toxins and maintaining health. However, modern lifestyles can overwhelm the kidneys, putting an increasing number of people at risk for renal failure. Early screening and diagnosis are key to treating kidney disease. 🩺 ------------------------------------------------------------------------- Diagnostic Kit for Urine microalbumin (Colloidal Gold) 🧪 is used for the semi-quantitative detection of microalbumin (Alb) levels in human urine samples, providing valuable assistance in the early diagnosis of renal impairment. This has significant clinical importance in preventing and delaying the progression of diabetic nephropathy. 🩹

Insulin resistance is a metabolic condition where cells in the body become less responsive to the hormone insulin, leading to impaired glucose uptake and elevated blood sugar levels. In orthomolecular medicine, which emphasizes the role of nutrients in health, nutritional causes of insulin resistance include deficiencies in certain vitamins and minerals. Key factors include low levels of magnesium, which is crucial for glucose metabolism, and vitamin D deficiency, which affects insulin sensitivity. Additionally, excessive intake of refined carbohydrates and sugars can lead to chronic high blood sugar levels, contributing to insulin resistance. Omega-3 fatty acids, found in fish oil, are also highlighted for their role in reducing inflammation and improving insulin sensitivity. These insights are supported by research showing that micronutrient supplementation and a balanced diet rich in whole foods can help mitigate insulin resistance. In summary while being on Anti-Diabetic Drugs for managing Blood Glucose levels optimally, it is necessary to supplement with the right nutritional supplements to enhance the Insulin Sensitivity, reduce inflammations and better manage the side-effects of Anti-Diabetic drugs. Suggest Top Diabetologists and Diabetes Management Experts from various Health Care models. If you are suffering from Diabetes Type 2, and need support with its ongoing complications, like Gut dysbiosis, Bloating, Muscle Wasting, Neuropathies, Lack of restorative sleep etc and Need Expert guidance on Diabetes Management & Reversal a more Holistic approach to Managing Diabetes Mellitus which is a lifestyle and a metabollic syndrome based disorder and can be reveresed in early stages..One can choose to reach out to the Expert Diabetes Doctors at Cure4Pain Clinic. The best doctors for diabetes recognize that managing this condition requires a comprehensive approach beyond just addressing symptoms. They stress the importance of understanding diabetes at a cellular level, focusing on metabolic pathways and insulin resistance unique to each patient. Identifying and addressing underlying factors, such as nutritional imbalances and lifestyle factors, is vital for effective diabetes treatment. Experts in diabetes care in India advocate for personalized strategies that activate the body’s natural regulatory mechanisms. For those seeking expert guidance, the diabetes specialists at Cure4Pain Clinic in India offer a science-backed approach. With over nine years of experience, they provide holistic and integrative diabetes care, including specialized programs for managing type 2 diabetes and reversing pre-diabetes. #InsulinResistance #OrthomolecularMedicine #NutritionalHealth #Magnesium #VitaminD #Omega3 #GlucoseMetabolism #HealthyEating #ChronicDisease #NutrientDeficiency

Loss of skeletal muscle mass and function is a major concern for clients/patients on GLP-1 medications. Check out this updated paper on the importance of nutrition and protein 👇👇 Thanks Carla Prado, PhD, RD, FCAHS W Scott Butsch Steven Heymsfield Jeffrey Mechanick Sandra Christensen, MSN, ARNP, FNP-BC, MFOMA, FAANP Osama Hamdy Zhaoping Li, MD, PhD 👏👏 Strategies for minimizing muscle loss during use of incretin-mimetic drugs for treatment of obesity https://lnkd.in/egwrdTyA #musclematters #nutrition #GLP1s #obesity #dietitians #stregth #healthnotweight

PRAGVAMSHOO INDIA Life Sciences Pvt Ltd ++0091 9480202099 sicher@grazioss.com www.grazioss.com www.facebook/pragvamshoo β-glucan- Daily life reforms that include a diet high in fiber may lower the risk of developing diabetes, in this context; the presence of soluble dietary fiber in carbohydrate rich foods has been widely recognized for its effect on post-prandial glucose response (PPGR). Among these, barley derived β-glucan have received tremendous attention for their biological effects, including their ability to reduce PPGR. Beta-glucans are potentially beneficial in the treatment of diabetes and associated cardiovascular risks, Studies have shown that beta-glucans could reduce hyperglycemia, hyperlipidemia, and hypertension. Thus, beta-glucan rich “SICHER” could produce new approaches for the treatment of diabetes. The prevalence of Diabetes Mellitus and, particularly, type 2 diabetes is increasing every year worldwide. Therefore, changed glucose homeostasis is associated with altered gut microbiota and with the development of type 2 diabetes mellitus and related complications. Among other concerns, an important aspect within this issue is the reversion of dysbiosis reported to be present in Type 2 Diabete patients, in which diet plays a key role, and particularly dietary fiber has shown a promising position. 𝛽-glucans are heterogeneous non-starch polysaccharides, constituted by D-glucose monomers linked through different 𝛽-glycosidic bonds, and changes in their structure or molecular weight affect the expressed biological properties. They appear in certain cereals, yeasts, or mushrooms and are widely known by their hypocholesterolemia effect. Studies explored the current knowledge on the potential of 𝛽-glucans to modulate glucose homeostasis due to their prebiotic action, by performing a bibliometric analysis. The bibliometric analysis showed that, despite the high number of references dealing with                     𝛽-glucan and diabetes, there are few articles on glucans, diabetes, and intestinal dysbiosis. The detailed study on preclinical studies and clinical trials conducted during the last decade showed an improvement in glucose homeostasis due to 𝛽-glucan supplementation, studies on biochemical markers, and gut microbiota, and 𝛽-glucan are scarce. Nevertheless, existing data showed, both in animals and humans, a tendency towards an increase in beneficial bacteria and in the production of short-chain fat acids (SCFAs), particularly butyric acid. These aspects recommends for 𝛽-glucan as a prebiotic coadjutant in the management of Diabetes Mellitus. ಪ್ರಾಗ್ವಂಶೂ ಭಾರತ ಲೈಫ್ ಸೈನ್ಸಸ್ ಪ್ರೈ. ಲಿ ++0091 9480202099 sicher@grazioss.com www.grazioss.com www.facebook/pragvamshoo