Małopolska Centre of Biotechnology UJ’s Post

#newpaper Our researchers in collaboration with Durham University and the John Innes Centre, have made a groundbreaking discovery in the fight against antibiotic resistance. Using high-resolution cryo-electron microscopy, they captured the most detailed images ever of DNA gyrase, a bacterial enzyme essential for DNA supercoiling and a key target for antibiotics. By revealing how the enzyme twists and stabilizes bacterial DNA in a ‘figure-of-eight’ loop, this research offers fresh insights for developing new, targeted antibiotics. "Seeing DNA gyrase in this fully open state is a major leap in understanding its complex mechanism." says Elizabeth Michalczyk - PhD student and first author of the article. This discovery could lead to next-gen antibiotics designed to bypass existing resistance, offering new hope in the battle against bacterial infections. Structural study on gyrase was funded by OPUS grant from NCN National Science Centre. CryoEM data was collected at the National Synchrotron Radiation Centre SOLARIS. Congratulations to the Authors! Jagiellonian University Full text can be found here: https://lnkd.in/e6WpNiCw Image was prepared by Sohit Chakraborta.