Medical Research Foundation’s Post

BioChat welcomes Ting Fu, PhD, of the University of Wisconsin, who has carved a career niche from a deep interest of intestinal health. We discuss mucosal immunity, gastrointestinal diseases, and more! Ting Fu, PhD, joins BioChat （https://hubs.li/Q02KvhG_0) to impart some wisdom on: - Turning a lifelong scientific passion for intestinal health into a career; - Hard work, support, and good fortune starting up a lab during the height of the pandemic; - Research into inflammatory bowl diseases, colon cancer, and gastrointestinal homeostasis

CAR-T cells are proving their worth in cancer therapy. In recent years, the possibility of rewiring them has been explored to treat conditions like autoimmune diseases. In a recent study, allogeneic CD19-CAR-T cells were deployed to this end. Manel Llado Santaeularia, PhD. and I discuss this on WeDoCRISPR. Hope you enjoy it and we'll see you in the next one. #CART #CRISPR #cancer #cancertherapy

A story about constellations. So, quite a few years ago, a (really) delightful young girl turned up to my clinic with an unexplained constellation of symptoms. Her cough and pneumonias would not clearly fit in any of the categories we routinely check. I noticed her thickened and yellow nails and remembered vaguely from medical school something about "yellow nail syndrome" (YNS), a condition so rare, that only about 150 cases are described in the medical literature. Following referral to my knowledgable genetics colleagues at Schneider Children's Medical Center of Israel, Efrat Sofrin-Drucker and Naama Orenstein, it indeed appeared that this was her diagnosis. The cause of YNS was unknown at the time. Luckily, the stars were constellated in a way that other clinicians and researchers were facing the same conundrum. And a bunch of geneticists, led by Hagit Baris Feldman, picked up the challenge and figured out how impaired signaling in some clever pathway may well explain the unusual presentation of YNS. This is a huge achievement, since once you understand a problem, a door opens to possible treatment (+/- prevention?) strategies. How gratifying it is to collaborate with such an exquisite constellation of professionals. It does take a village. P.S.: May I suggest that Wikipedia now change their statement about the genetic aspect of YNS, which currently says: "Although it has been described in families, it has been suggested that it might not have a genetic link."

The gastrointestinal (GI) tract is a complex and dynamic organ system essential for digestion, nutrient absorption & immune surveillance. In our recent webinar with Akoya Biosciences, Inc., John Hickey, PhD from Duke University shares how spatial biology is reshaping our understanding of the gastrointestinal tract, from cellular diversity to disease mechanisms and treatment insights. Watch it now: https://lnkd.in/giXq2zf9

Proteintech is excited to invite you to a special webinar on "Tips & Tricks for iPSC/hESC to Oligodendrocyte Differentiation" with Rana Fetit, Postdoctoral Research Fellow at the The University of Edinburgh. Event Details: 📌Date: May 16th, 2024 📌Time: 12pm US CT | 12pm BST | 1pm CEST Event Info: Oligodendrocytes are a highly important component of the central nervous system as they make up the insulating sheath of axons. As such, many researchers work on oligodendrocyte cultures differentiated from human iPSCs or ESCs to study demyelinating diseases such as Multiple Sclerosis (MS). However, maintaining culturing, and differentiating iPSCs/ESCs into oligodendrocyte progenitors, require precise focus and adherence to best practices Topics Covered: - Maintaining iPSCs/ESCs - Generating neurospheres and differentiating them into oligodendrocyte progenitors (OPCs) and Oligodendrocytes - Potential applications What to Expect: Rana Fetit will share insights, techniques, and best practices for successful differentiation. Whether you're a seasoned researcher or new to the field, this webinar promises valuable information and practical tips. Certificate of Attendance: Attendees will receive a certificate of attendance, and a link to watch the webinar will be available post-event. Registration: Secure your spot today by registering here: https://lnkd.in/eZNdq5GS Don't miss this opportunity to enhance your understanding of iPSC/hESC to oligodendrocyte differentiation. We look forward to your participation.

I am glad to share our recently published article "Copy Number Variants in Cardiac Channelopathies: Still a Missed Part in Routine Arrhythmic Diagnostics" Biomolecules 4.8 IF Many thanks to all colleagues especially the Great Juniors 💪🏻💪🏻💪🏻💪🏻 Maria Gnazzo: 🔝 We describe our cohort with channelopathies secondary to CNVs and we bring light to what has been previously described in literature: Please remember to check out for CNVs in SNV elusive patients 🌟 🌟 🌟 This can give better personalized management and prevent major events especially for asymptomatic genotype positive relatives 🙏🏻 Paper is available online at the following links: Website: https://lnkd.in/daYreUAa PDF Version: https://lnkd.in/d2XqVCWd

Excited to share our new publication in Annals of Internal Medicine! We've identified impaired Wnt/Planar Cell Polarity signaling as a key factor in Yellow Nail Syndrome (YNS). Specifically variants in CELSR1 and FZD6, play a significant role in congenital YNS. We also observed milder PCP pathway impairments in sporadic YNS. This breakthrough reveals the mechanism for YNS development. Read more: https://lnkd.in/dWmK2mb6 #YNS #raredisease #genetics #research  Thank you to everyone involved: Alina Kurolap, Chofit Chai, Orly Eshach Adiv, Tova Hershkovitz, Emily Avitan-Hersh, Ludovic Martin, Helene Humeau, Ulrich Schatz, PD Dr. med. Dominik Westphal, Prof. Dr. Silvia Lobmaier, Efrat Sofrin-Drucker, Patrick Stafler, Joshua Bugis, Irit Chermesh, Emilia Hardak, Polina Geva, Yaniv Zohar, Dov Hershkovitz, Adi Mory, Sumit Chatterji, Shoshana Greenberger, Michal Shteinberg Happy Holidays from the TGGR lab! https://lnkd.in/dEqm9BZk

Scientific inspiration can come from the most unexpected places. For National Institute of Dental and Craniofacial Research (NIDCR)'s Dr. Eva Mezey, dinner with a friend and fellow scientist whose lab focused on fish helped jumpstart the discovery of bone marrow cells that can make a substance capable of fighting infections and regulating overactive immune responses. Learn more about the #NIH_IRP research that led to this discovery: https://go.nih.gov/3bgeLYq

🔬 Exciting Research News! Our project IMPACT-PD of Team Vangheluwe has been awarded the prestigious Aligning Science Across Parkinson’s Competitive Supplement to continue our groundbreaking research through the Collaborative Research Network on Implications of Polyamine and Glucosylceramide Transport in Parkinson’s Disease for an additional 2 years! This collaborative effort brings together an exceptional international research consortium consisting of the Vangheluwe Lab and Baekelandt lab (KU Leuven), the Sidransky Lab (NIH), the Blanchard Lab (Mount Sinai) and the Lyons Lab (Aarhus University). Together, we'll be diving deeper into the relationship between key lysosomal PD-linked proteins such as ATP13A2, ATP10B, and GBA1 to reveal the precise molecular mechanisms of lysosomal dysfunction in Parkinson’s disease that are linked to impaired polyamine and glucosylceramide homeostasis. We are grateful to ASAP for supporting this critical research that brings hope to millions affected by Parkinson's disease worldwide. #ParkinsonsResearch

#analyticalchemistry news In the world of #analytical measurements, precision and sensitivity are pivotal. Today, I am thrilled to share a pioneering approach in virus detection, published in the reputable journal, Analytical Methods. Titled "Correction: Establishment and characterization of noro-VLP measurement by digital ELISA," this study brings forward remarkable advancements in the field of virology and analytical #chemistry. Led by a team of dedicated researchers, this paper delves into the development of a digital ELISA method for the measurement of norovirus-like particles, noro-VLP,. Noroviruses are notorious for causing gastrointestinal disorders, and having a sensitive and accurate detection method is crucial for public health safety. The researchers have utilised the digital ELISA technique, which significantly enhances the sensitivity of detecting these particles compared to conventional methods. This innovation relies on advanced #analyticalchemistry techniques, providing a robust tool for early detection, potentially leading to better outbreak management and control. What makes this study noteworthy is its practical application in real-world scenarios. By improving the sensitivity and accuracy of noro-VLP detection, it offers public health officials a superior tool in the fight against viral outbreaks, especially in densely populated or vulnerable areas. With the potential to enhance response strategies to noro-related outbreaks, this work highlights the critical role of #analyticalmethods in safeguarding public health. This is a prime example of how advancements in #chemistry and analytical methods can have a profound impact on everyday life. The ability to detect pathogens quickly and accurately not only protects communities but also underlines the importance of continuous research and innovation in the field. To delve deeper into the intricacies of this study and understand its implications, I invite you to explore the detailed work here: [URL provided]. #DigitalELISA #Virology #PublicHealth #ScientificResearch, If you want to know more about #analyticalchemistry news, follow me: https://lnkd.in/d29pbjb9