Metabolon, Inc.’s Post

Cell by Cell Press celebrated its 50th anniversary by publishing a collection of articles focusing on #metabolism, which obviously has implications for #aging and most chronic diseases. Below are a few articles that caught my attention. #Obesity Transforming obesity: The advancement of multi-receptor drugs https://lnkd.in/d3ZpY8fC Antagonizing GIPR adds fire to the GLP-1R flame https://lnkd.in/d6YuqiNh Obesity disrupts the pituitary-hepatic UPR communication leading to NAFLD progression https://lnkd.in/dTZGjhZ3 #Cardiovascular disease Human cardiac metabolism https://lnkd.in/dMsNuwCe Pioneering new frontiers in circadian medicine chronotherapies for cardiovascular health https://lnkd.in/dczcuy5r #Cancer Oncogenic fatty acid oxidation senses circadian disruption in sleep-deficiency-enhanced tumorigenesis https://lnkd.in/dGVdHb23 100 years of the Warburg effect: A cancer metabolism endeavor https://lnkd.in/d9M3EEFG #Autoimmunity Metabolic dysregulation of lymphocytes in autoimmune diseases https://lnkd.in/dEme7qsg #Biomarkers Thermal facial image analyses reveal quantitative hallmarks of aging and metabolic diseases https://lnkd.in/ddKbzZGV Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease https://lnkd.in/dpaNQx_4 #Mitochondrial biology  The rate and nature of mitochondrial DNA mutations in human pedigrees https://lnkd.in/dyV9ntka

❤️Unleash the Power of Cardiovascular Biomarkers with Biotime's ST2 Rapid Quantitative Test!🔬 Growth Stimulation expressed gene 2 (ST2) is a game-changing biomarker in the world of cardiovascular health. As a member of the interleukin-1 receptor family, ST2 holds the key to unlocking critical insights into various heart-related conditions:📒✏️ ✨Coronary Artery Disease ✨Myocardial Infarction ✨Atherosclerosis ✨ Giant Cell Arteritis ✨ Acute Aortic Dissection ✨ Ischemic Stroke ✨ Obesity and Diabetes Soluble ST2 protein (sST2) is a powerful indicator of vascular health, providing both diagnostic and prognostic value for these cardiovascular challenges. 🚀Biotime's ST2 Rapid Quantitative Test delivers fast, accurate, and reliable measurement of sST2 levels, empowering clinicians to make timely and informed decisions for managing cardiovascular health.💪 🔗https://lnkd.in/gAfbfhWN #CardiovascularHealth #Biomarkers #ST2 #HeartDisease #CoronaryArteryDisease #MyocardialInfarction #Atherosclerosis #GiantCellArteritis #AcuteAorticDissection #IschemicStroke #Obesity #Diabetes #MedicalTechnology #DiagnosticTools

Proteins in the blood and serum reflect both a person’s genetic makeup and their environmental exposures, and can therefore be potentially used to predict and modify disease risk. Art Schuermans, Ashley Pournamdari, M.D., Michael Honigberg, Pradeep Natarajan, and colleagues applied this approach to cardiovascular disease, analyzing the proteomes of about 45,000 UK Biobank participants and identifying 820 protein-disease associations. They then used Mendelian randomization to identify proteins that play a causal role in disease and could be therapeutics targets. Finally, they generated protein-based risk scores that improved cardiac disease prediction in the general population. Read more in Nature Cardiovascular Research. #BroadInstitute #Science #ScienceNews #Research #ScientificResearch

🚨 Breakthrough in Atherosclerosis Research! 🚨 Recent findings spotlight the enzyme NAT10 as a key player in the progression of atherosclerosis, revealing its significant impact on macrophage behavior and inflammatory responses within arterial walls. 🔍 Key Highlights: - NAT10 levels are notably elevated in patients with atherosclerosis, linking it directly to inflammation and plaque formation. - Targeting NAT10 can shift macrophage polarization from pro-inflammatory M1 to anti-inflammatory M2 types, reducing inflammation. - The interaction between NAT10 and TLR9 presents an exciting therapeutic target for future treatments. This research opens new avenues for developing therapies aimed at mitigating chronic inflammation associated with cardiovascular diseases. 💡 Click the link to explore how modulating NAT10 could revolutionize treatment strategies! #Atherosclerosis #CardiovascularHealth #ClinicalResearches #InflammationResearch #MacrophagePolarization #MedicalResearch #NAT10 #Publications #MarketAccess #MarketAccessToday

As cardiovascular and metabolic diseases (CVMD) continue to impose a growing burden on society, research into new biomarkers and therapeutic targets is crucial. This recent review, published in Cell Communication and Signaling, explores the role of Metrnl, a secreted protein, in regulating glucose and lipid metabolism while maintaining cardiovascular system homeostasis. The study highlights Metrnl's potential in predicting and treating a range of conditions, including: Atherosclerosis Heart failure Hypertension Diabetes Obesity 🔍 Dive into the findings to understand how Metrnl could pave the way for new therapeutic strategies in CVMD: https://lnkd.in/g2yjbrjQ #CardiovascularHealth #Metabolism #Research #CVMD #Biomarkers #TherapeuticTargets #HealthcareInnovation

Register for our December webinar where we explore protein and metabolite biomarkers that are associated with risk of imminent myocardial infarction and a prediction model that could be used for early identification. https://mtbln.co/4dbqau #Metabolomics #Proteomics

🌟Exciting News in Diabetes Research!🌟 I’m thrilled to share insights from a recent study by Eishani K. Sokolowski and colleagues titled "Multi-omic human pancreatic islet endoplasmic reticulum and cytokine stress response mapping provides type 2 diabetes genetic insights," published in Cell Metabolism. This research sheds light on how stress in pancreatic cells contributes to type 2 diabetes (T2D). 🔍Key Insights: - The study reveals that stressors like endoplasmic reticulum (ER) stress and inflammation can lead to dysfunction and apoptosis in insulin-producing beta cells. - The genetic variant rs6917676 affects how these cells respond to stress, increasing their breakdown and disrupting insulin production, which contributes to T2D. 💡Why It Matters: Targeting the MAP3K5 pathway with inhibitors may protect pancreatic cells and improve their function, offering new therapeutic avenues for T2D. As we uncover the mechanisms behind diabetes, this research is crucial for developing better treatments that can enhance patient health. 📈 I encourage everyone to explore this study and its implications for diabetes care. Together, we can make a difference! #Type2Diabetes #Research #Genetics #Healthcare #Innovation Reference: Sokolowski, E. K., et al. (2024). Multi-omic human pancreatic islet endoplasmic reticulum and cytokine stress response mapping provides type 2 diabetes genetic insights. Cell Metabolism. (https://lnkd.in/gYTq34FP)

Join us in supporting Parkinson's Awareness Month as we illuminate the metabolic mysteries of this complex disease. Here are some insightful pieces of information about Parkinson’s and metabolomics' role in unlocking the disease's mysteries: - Dysregulated Metabolites: Metabolomics studies have identified specific metabolites that are dysregulated in Parkinson's patients compared to healthy individuals. These metabolites include neurotransmitters, lipids, and amino acids. - Mitochondrial Dysfunction: Metabolomics research has highlighted the role of mitochondrial dysfunction in Parkinson's disease. Changes in metabolites involved in energy production and oxidative stress contribute to mitochondrial impairment, a hallmark of the disease. - Biomarker Discovery: Metabolomics holds promise for identifying biomarkers that can aid in the early diagnosis and prognosis of Parkinson's disease. These biomarkers offer insights into disease mechanisms and potential therapeutic targets. Through cutting-edge metabolomics research, we're paving the way for new insights and breakthroughs in diseases affecting our future. Together, let's shine a spotlight on Parkinson's and drive innovation toward a brighter tomorrow. #ParkinsonsAwarenessMonth #Metabolomics #Research #Innovation https://lnkd.in/gYNuD64k

New from JN Learning: Prognostic Value of Cardiovascular Biomarkers in the Population https://lnkd.in/gxVc9ra4

In this post-pandemic era of clinical practice, we are seeing a surge of fatigue, immune dysregulation, brain fog, gut microbiome issues, hormone challenges and an increase in both cancer incidence and recurrence. That requires practitioners to connect the dots. Our understanding of the gut-brain-immune communication has deepened, cultivating sympathetic balance plays a greater role in pathophysiology of chronic diseases more than ever before. Post-viral fatigue recovery requires strategies that target immune rejuvenation as the way forward to cultivating a return of vital energy. Cancer treatments require analysing the tumour immune micro-environment to sustain results and prevent recurrences. Join Dr Wafaa Abdel-Hadi, MD and Kristi Morlan-Hughes ND, IFMCP, FMCHC for a clinical conversation, as they explore clinical pearls and what is working most effectively when they apply Metabolic Nutrition-based nutraceuticals. Hosted by NutriDyn Register online at https://lnkd.in/gyTTUAht #ipmcongress #metabolicsyndrome #integrativemedicine #personalisedmedicine #lifestylemedicine #functionalmedicine #wholepersonhealth