Mind & Matter’s Post

Protein drugs hold great promise as #therapeutics for a wide range of diseases. However, with smaller proteins one of the greatest challenges is their short circulation half-life. Earlier this year, we shared our positive results of the first in-vivo study of a Interleukin-2 conjugate for treating autoimmune diseases. It uses our novel site-specific conjugation technology for half-life extension via site-specific conjugation to a fatty-acid containing peptide. So, what is it that makes #VALANX approach so unique? ▪ We have perfect control over the site of conjugation. ▪ We have perfect control over multiple sites of conjugation. ▪ Allowing you to freely choose any site for conjugation in any protein. We found the perfect site for our lead asset. Interested to find your perfect conjugation site? Read the full article https://lnkd.in/dz8pkvsW and contact us. #HealthInnovation #BiotechnologyInnovation #ProteinConjugation

Acetaminophen and Hepatotoxicity: Key Insights Acetaminophen, widely used as an antipyretic and analgesic, is primarily metabolized by the liver. Under normal circumstances, it’s converted to non-toxic metabolites, but a small fraction is transformed into a toxic compound known as NAPQI. This is usually neutralized by glutathione, but during an overdose, glutathione is depleted, causing dangerous levels of NAPQI and resulting in hepatotoxicity. Interestingly, acute ethanol ingestion can decrease the formation of NAPQI by competing with acetaminophen for the enzyme cytochrome P450 2E1. However, chronic alcohol consumption increases the risk of hepatotoxicity by upregulating this enzyme and depleting glutathione. Despite this, ethanol should not be viewed as an antidote for acetaminophen toxicity. Understanding these metabolic interactions is crucial, especially in clinical contexts where acetaminophen overdose is suspected. Stay informed, stay safe! #dailymedicalinsight

Check out this Medscape article on oral weight loss drugs featuring our lead drug in development, which is designed to be released in the distal small intestine to restore nutrient-sensing pathways, regulating appetite, glucose metabolism and energy expenditure: https://wb.md/3XbAPyT

Novo Nordisk aims for CagriSema, a combination of semaglutide and cagrilintide, to achieve 25% weight loss, surpassing the weight loss rates of current drugs like Wegovy (15%) and Zepbound (21%). Furthermore, it leverages amylin, which could improve satiety with fewer side effects. Novo suggests CagriSema may prevent weight regain and slow metabolic slowdown, a common issue in obesity treatments. However, CagriSema requires a complex dual-chamber injection system to keep its two components separate until injection, which could hinder production scalability. Wait until word gets out that Calocurb boosts GLP-1, CCK and PYY - all with a few, all natural, daily capsules! #weightloss #obesity #GLP1

The obesity drug market was over $20 billion last year and could reach $131 billion by 2028. That 27% annual growth estimate compares with a prior projection of 13%. It's not hard to see why there is a scramble for assets, and why next generation GLP drugs are on everyone's radar. On that note, Roche are planning on fast tracking their anti-obesity medication they acquired from their Carmot purchase. They are intending to make it to market by 2029, underscoring the difficult of bringing a drug to market quickly (even in this case, it's a Herculean task!). Roche have published impressive results, with patients on the once weekly injection losing an average of 19% body weight before the 6 month mark. https://lnkd.in/g7gPeASC

Magi nootropic supplements were developed through three years of rigorous pharmaceutical testing and trials, where we measured hundreds of neuro-physiological biomarkers and mapped them across different mind states and intersubjective experiences. We're thrilled to witness that our biohacking and tech-savvy customers get the same results. When meditating, our alpha brainwaves are extended, allowing our analytical mind (beta brainwaves) to slow down while we are fully present and lucid. If developing a meditation practice has been difficult for you, or you meditate but want to go deeper, try Stard! #stard #meditationsupplement #meditation #meditationaid #openawareness #vipassana #zazen #relaxation #naturalsupplements #ancestralmagi #magisupplements #harmala #espand #syrianruesupplements #psychoactive #legalpsychedelics #psychedelics #hypnagigia #alteredstates #consciousness

MitoQ for Arteries? -- Did taking MitoQ, a compound related to CoQ10, improve cardiovascular fitness in older men and women? See what a recent study found in our CoQ10 & Ubiquinol Supplements Review, which includes our Top Picks among CoQ10 and ubiquinol supplements. https://bit.ly/4aYNkBy

Presented is an older clinical study examining CBD's effects on IBS. While it showcased benefits typical of CBD studies, inadequate bioavailability delivery methods hindered its potential as a medication substitute. Enter Pico IV, the game-changer! Intravenous CBD bioavailability emerges as a pivotal factor in all research. Join us in reshaping health and wellness through non-psychoactive cannabinoids like CBD. #CBDIV #Bioavailability #CBDIntravenously #PicoIV https://lnkd.in/gfJiSXMe

Recently, I came across something related to the consumption of alcohol that piqued my interest to read more about the role of the MEOS system within our body, which is responsible for the metabolism of ethanol in our body. MEOS, is also known as the Microsomal Ethanol-Oxidising System. When a person drinks alcohol heavily, the excess alcohol will be metabolised by the MEOS system in the liver, as enzymes like alcohol dehydrogenase are responsible for the oxidation of ethanol. It is shown that enhanced ethanol oxidation is associated with cross-induction of the metabolism of other drugs, resulting in drug tolerance. (Lieber, 2006) This could result in lower drug efficacy in the long run as a result of extended periods of heavy drinking of alcohol, which could explain why certain alcoholics may face issues with the effectiveness of the drugs they consume due to the cross-induction effects of the metabolism of certain drugs, resulting in higher tolerance to drugs. Moreover, alcohol is also listed as a Group 1 carcinogen, amongst asbestos, tobacco and radiation, by the World Health Organisation (WHO). So the next time we choose to drink, probably it is best that we drink in moderation, cheers to a toast 🍺 👍

🌿 Upcoming Webinar: Unlock the Power of Beta-Caryophyllene 🌿 Discover how beta-caryophyllene, a natural compound found in cannabis, can revolutionize the management of chronic inflammation. Join Dr Philip W. Blair, M.D. (Colonel, US Army Retired), an expert in cannabinoid science, as he explores: ✨ How beta-caryophyllene targets the endocannabinoid system and CB2 receptors. ✨ Its potential for managing conditions like arthritis, IBS, and neuroinflammation. ✨ Evidence-based insights on dosage, safety, and therapeutic applications. Webinar Details: 📅 Date: Saturday, 7 December ⏰ Time: 9am AEDT 📍 Location: Online Don’t miss this opportunity to learn from one of the leading experts in ECS and CBD therapy! 👉 Register now: https://lnkd.in/gX6eFrjx #BetaCaryophyllene #DrPhilipBlair #MedicinalCannabis #ChronicInflammation #CannabinoidScience #Webinar