Mount Sinai Hospital (Toronto), Sinai Health’s Post

I had chalked ESM3 up as just another AI hypetrain. But generating a protein by describing it using natural language is what makes this such a landmark achievement. This week I had the pleasure of writing about some awesome new releases in #synbio - ESM3 and the new CRISPR-less DNA manipulation technique. Both are extremely promising and honestly quite sci-fi. ESM3 being able to generalise and reason over the endless reams of biological sequence data to actually identify patterns, and navigate through them using natural language... it's like we've cracked the Rosetta Stone but for biology. It's hard for me to convey just how exciting I think that is. And CRISPR-less DNA manipulation... well, I mean, that's not huge in itself. TALENs and excision enzymes could already do this. The actual fascinating hook of bridge RNA recombinases is that it enables DNA manipulation *without breaking any DNA*. Which, if you think of genomes as essentially being LEGO sets whereby the bricks are the base pairs... well, it just makes no physical sense right? They key thing being that it uses covalent intermediates. Essentially, unlike CRISPR, it never leaves a broken strand exposed. It just swaps one bond for another. This was so much fun to write about, and I look forward to seeing how these tools end up shaping the future of the bioeconomy. This was a new kind of article for me as well - would love some feedback if anyone gets a moment to read it! 🧪

Don't miss Canadian BioGenome Project's bioinformatician Afiya Chida discuss the Nextflow pipeline we use to assemble genomes! Check out the pipeline coded by Solenne Correard: https://lnkd.in/gkuCiKGx Check out her poster and ask questions LIVE at #BG24! Wondering how to gain access? Follow these simple steps: 1. Register for the conference 🔗 https://lnkd.in/ghhx6UAt 2. Use the password and login details once registered to allow you to enter the portal. 3. On the portal homepage, scroll down and click on posters. 4. Enjoy learning from 40+ different research posters from around the world, and ask questions via the Slido box after accepting the terms and conditions.

FY2024/03 Earnings presentation - Video record data (available May 10, 2024 - July 22, 2024) https://lnkd.in/gSE7UHzx Around the 33-minute mark of the video, there is a comment related to the life science business. IR library https://lnkd.in/dVKEXNpb #Cell3iMager　 https://lnkd.in/gT2K79hU #Regenerativemedicine #Drugdiscovery #Cancerresearch　#Developmentalbiology　#Personalizedmedicine #SCREEN

As we reflect on yesterday's #SpeakerSeries #webinar, "Preparing #EHRs for the #Genomic Age", we're shining our #CitationSpotlight on the 2020 #GeneticsInMedicine paper, "The interface of #GenomicInformation with the #ElectronicHealthRecord: a points to consider statement of the ACMG - American College of Medical Genetics and Genomics" by Dr. Grebe, George Khushf, Margaret Chen, Dawn Bailey, Marc Williams, the ACMG Social, Ethical and Legal Issues Committee, and others. Read the paper below to learn more: https://lnkd.in/gJ9WRAp

🧬 A recent study published by Genentech in 𝐴𝑛𝑎𝑙𝑦𝑡𝑖𝑐𝑎𝑙 𝐶ℎ𝑒𝑚𝑖𝑠𝑡𝑟𝑦 explores a new online platform utilizing lipid nanoparticles for RNA delivery, showcasing significant advancements in mRNA sequencing technologies. 🧪💡 This research highlights an innovative online digestion-analysis platform, which significantly reduces the time and complexity involved in sequencing mRNA. By integrating RNase reactors with 2D-LC-MS instrumentation, this method offers a streamlined approach to accurately map nucleotides, ensuring higher sequence coverage and minimizing potential contamination. 🎯 𝐊𝐞𝐲 𝐓𝐚𝐤𝐞𝐚𝐰𝐚𝐲𝐬: 🚀 The new platform reduces digestion time from 15 to less than 5 minutes. 🔬 Achieves higher sequence coverage compared to traditional offline methods. 🧐 Allows for detailed analysis with reduced sample sizes and lesser risk of RNase contamination. 🌐 Potential to become integral in future multi-dimensional LC-MS setups for broader applications. This research not only paves the way for more efficient mRNA therapies but also enhances our ability to study and manipulate RNA, a cornerstone of genetic medicine. 🔗 Link to the publication: https://lnkd.in/gpNqrA73 #ScienceInnovation #mRNA #Biotechnology #GeneticResearch #HealthcareInnovation Alexandre Goyon, Brandon Scott, Pete Yehl & Kelly Zhang

Did you know, in 2010, scientists at the J. Craig Venter Institute created the first synthetic bacterial cell, named Mycoplasma mycoides JCVI-syn1.0. This organism's entire genetic material was synthesized from chemicals, marking the first instance of creating "life" wholly controlled by man-made genetic instructions. This breakthrough not only advanced our understanding of the fundamental principles of life but also sparked a profound ethical and philosophical debate about the nature and future of synthetic biology. The creation of this synthetic cell is a prime example of the innovation that defines global laboratories. This milestone not only expanded our knowledge of life’s blueprint but also illustrated the broader scope of laboratory impacts—from groundbreaking research to vital diagnostics. On World Lab Day, we celebrate not just these innovations but also the everyday contributions of diagnostic laboratories. These facilities are essential for the timely diagnosis and management of diseases, enabling healthcare providers to deliver precise treatments based on early detection. Biorus is committed to supporting these efforts by providing top-quality solutions that enhance laboratory research and diagnostics, ensuring accurate and timely results for better patient care. #worldlabday2024 #WLD24 #diagnostics #innovation #facttuesday #factasticbybiorus #biorus

Delighted to share my solo venture, reviewing structural and mechanistic basis of RNA-based and RNA-free forms of RNase P towards substrate pre-tRNA recognition, encompassing 50 years of research, published in WIREs RNA. https://lnkd.in/gqjuczT5 This ancient bad boy was mostly known to exist as a ribonucleoprotein complex across prokaryotes and eukaryotes during the 20th century. However, the discovery of various protein-only forms in the 21st century has only reignited the field with fascination towards its evolutionary trajectory. This overview navigates through the exhaustive diversity displayed by the ever-mystical RNase P, narrating the architectural features as well as clinical / biotechnological applications complemented with visually appealing illustrations to keep the reader's palate flavourful. #RNaseP #PRORP #HARP #tRNA #RNAprocessing

📍 CellRank 2: unified fate mapping in multiview single-cell data Weiler et al. presented CellRank 2, a versatile and scalable framework to study cellular fate using multiview single-cell data of up to millions of cells in a unified fashion. Key points 🔸 Recovering terminal states and fate probabilities across data modalities 🔸 Combining transitions within and across experimental time points 🔸 Estimating cell-specific transcription and degradation rates from metabolic-labeling data. ➡ More details: https://lnkd.in/eey_4vhu #HelmholtzMunich #spatialomics #spatialbiology #singlecellanalysis #singlecell

Need a quick recap on single-cell and spatial multiomics and their applications in medical and environmental science. Check out our new review🎉 Marija Velickovic Kristin E. Burnum-Johnson

In the latest NEBinspired blog post, learn about a new method to directly detect 5hmC at single-base resolution with NEB scientist, Dan Evanich, Ph.D.. https://lnkd.in/eFj5EeSX