MultiPark- Multidisciplinary neuroscience research at Lund University’s Post

🍴 MultiPark Lunch Seminar 🍴 In today’s lunch seminar, we delved into cutting-edge neuroscience, exploring the intricate relationships between neuropathologies and brain health. The session gave us a taste of new scientific insights from various neurodegenerative pathologies. 🧠  Sophie Mastenbroek dived into the effect of Lewy Body pathology on cognition Early-Onset Alzheimer’s disease. Did you know that co-morbid Lewy body pathology can shape the clinical progression of Alzheimer’s disease (AD)? While this is well-documented in typical AD cases, its role in early-onset Alzheimer’s disease (EOAD)—a rare form where symptoms appear before age 65—remains unclear. 🔍In her latest study, Sophie Mastenbroek from Oskar Hansson's lab explores the effects of Lewy body co-pathology on biomarkers and cognition in EOAD. 💪 Marie Sjögren, PhD working in the group lead by Maria Björkqvist spoke about muscle atrophy in Huntington’s disease and the protective effect of ghrelin. Skeletal muscle wasting is a common challenge for Huntington's disease (HD) patients, significantly affecting their quality of life. Satellite cells are progenitors of muscle tissue and important for repair. In her latest research she dives into: 🔍 The role of satellite cells in HD. 🔍 How the HTT CAG repeat expansion impacts these cells. 🔍 The protective effects of ghrelin, a gut hormone known to regulate energy metabolism and counteract catabolism in HD models. 🧠 Amanda Annettesdotter, PhD student with Laura Wisse presented new Insights on Amygdala degeneration in neuropathologies. The amygdala, an early hotspot for neuropathologies, is strongly linked to volume loss caused by conditions like tau and TDP-43. Did you know that early accumulation of different neuropathologies often target different subregions of the amygdala? In her latest study, Amanda analyzed postmortem data from individuals with and without neurodegenerative diseases to explore: 🔍 The connections between four key pathologies (tau, amyloid-β, TDP-43, and α-synuclein) and amygdala volume loss. 🔍 Which subregions of the amygdala are most affected by these pathologies. Thank you to everyone who joined and contributed to the engaging discussions! 🧠✨ #AlzheimersDisease #HuntingtonsDisease #LewyBody #biomarkers #tau #TDP43 #SatelliteCells #neuroscience #Dementia #Ghrenlin #Amygdala