NanoVation Therapeutics™’s Post

📢 Excited to share our new iteration of the PhoreMost pipeline, advancing our phenotypic screening applications - GlueSEEKER! Watch this space... or should I say, you'll be "GLUEd to your (our) Screens?!?!". No, I most definitely shouldn't, that's a terrible play on words. The technology is cool though! Check it out below! #MolecularGlues #TPD

Our customized oligonucleotide service is designed to meet your individual needs with precision and reliability. Based on our pioneering click chemistry and patented technologies, we modify your DNAs, RNAs and even LNAs for your specific applications in therapeutics and drug development.   Why choose us? *Customized synthesis: Tailor-made DNA, RNA or LNA oligonucleotides to meet your specific project requirements. *Wide range of modifications for your candidate: cell targeting reagents like sugars, fatty acids, nucleotides and many more. As well as fluorescent dyes which can be simultaneously attached to your oligonucleotide to check distribution and can be used as delivery assay. *High purity and quality: Strict quality controls ensure consistent, high purity products. *Fast turnaround time: Efficient processes that deliver your oligos exactly when you need them. *Expert support: A dedicated team of scientists provides comprehensive support and advice. Read the latest publication: https://lnkd.in/ecs9ZKB4 Design your Oligos now: https://lnkd.in/dwUNqS98 #research #oligonucelotide #click #therapeutics #ResearchInnovation #CustomSynthesis #ScientificResearch #Biotechnology #drugdevelopment

Understanding the properties linked to LNP function is key for mRNA applications, so what characterization tools are available? Register to our FREE webinar👇 🗓September 24 🕐16:30, to find out! Secure your spot 👉https://lnkd.in/dT5B33jx Our nanoparticle tracking analysis (NTA) expert Agnieszka Siupa will be joined by University of Utrecht LNP researcher Mariona Estapé Senti to discuss the use of fluorescence labelling techniques to inform property-function relationships in mRNA-LNP delivery vectors. Mariona Estapé works as a Postdoctoral Researcher in the Nanospresso-NL project, which aims to develop technology for producing personalized nucleic acid therapeutics at the point of care. Here’s what you’ll learn: • How to create robust physicochemical profiles of size and concentration using dynamic light scattering and NTA 👩🔬 • How to detect mRNA in lipid nanoparticle vectors 💉 • How to optimize fluorescence labelling for reliable use 🔬 #LNP #MRNA #Pharma

-GSK announces appointment of Dr. Jeannie Lee, renowned for her groundbreaking work in RNA biology and drug development, to its Board of Directors. -Dr. Lee's extensive experience in academia and biotech entrepreneurship, including co-founding Translate Bio and Fulcrum Therapeutics, enhances GSK's strategic vision in scientific innovation. -Sir Jonathan Symonds, Chair of GSK, expresses enthusiasm for Dr. Lee's appointment, citing her expertise in RNA biology and epigenetics as invaluable assets aligning with GSK's research priorities. To know more, read the full article on #theenterprise #GSK #JeannieLee #BoardAppointment #RNA Biology #BiotechInnovation#globalbusiness #theenterprisenews #followformore #global #finance

And the journey continues...here is the second live webinar of the Hit ID series, don't miss the chance to explore the latest technologies and strategies on Protein Sciences! Join us on June 4th or register to receive the link to the on demand version. #researchneverstops #drugdiscovery #proteinsciences #Evotec #HitID

Symeres is happy to announce its participation in the upcoming RSC/SCI Symposium on GPCRs in Medicinal Chemistry, scheduled for October 2-4th, 2024, in Verona, Italy. Representing Symeres at the symposium will be Luc Van HIJFTE and Ana Rioz. During the event, Luc van Hijfte will deliver a talk titled "A New Dual Mode of Action to Treat Pain - From Scratch to Preclinical Candidate," offering insights into innovative approaches in pain treatment. This symposium is a prominent event focused on the latest advancements in G protein-coupled receptor (GPCR) research, particularly their role in human disease and modern medicine with expertise in medicinal chemistry, structural biology and drug discovery. Topics covered here will consist of case studies in GPCR drug discovery, advances in our understanding of structural biology that impacts drug design to showcasing novel drug discovery approaches that modulate GPCRs. Symeres looks forward to engaging with the scientific community, sharing knowledge, and exploring potential collaborations in the field. We look forward to meeting you there!  #gpcr #research #drugdiscovery #symeres #modulation #structuralbiology #preclinicalcandidate #paintreatment #partnerships #chemistry #collaborations #conference #medchem

Check-out our latest paper on innovative approach to cold chain eradication!

With one week until RNA at the Bench and Bedside IV, we’re looking forward to forging new collaborations and engaging in innovative dialogue that will advance the scientific community’s understanding and pursuit of nucleic acid medicines. On Monday, 12/9, Ionis’ Ian Huggins, a Research Fellow in the Medicinal Chemistry Group, will present on ligand mediated delivery of oligonucleotides across the blood brain barrier. On Tuesday, 12/10, Executive Director of Clinical Development for Ionis, Becky Crean, PhD, will share insights on the antisense oligonucleotide approach to developing a therapeutic for Angelman Syndrome. Thank you to our co-organizers, Alnylam Pharmaceuticals, Nature Biotechnology, and UC San Diego School of Medicine. Explore all sessions and learn more about the conference: https://lnkd.in/eu89e9uJ

Less than 2 weeks to go! 🇺🇸 Structure-Based Drug Design Summit: Driving Exploration of 3D Protein Structures for Drug Discovery and Development 🧠 Expertise Partner and Speaker 📆 June 11-13 2024 📍 Hilton Boston at Logan Airport, Massachusetts, USA Don't miss the opportunity to connect with Eva Cunha, PhD, our head of Cryo-EM as she presents her seminar on the Opening Day Titled, 'Cryo-EM Structural Determination of Therapeutic Targets' The talk will cover: ✍️ Elucidating the molecular mechanisms to direct drug design approaches. ✍️ High-resolution small molecule and biologics structural determination ✍️ Case studies for elucidation of GPCRs, cRAF, MutS-b, CDK7/CycH If you’re coming and would like to meet to discuss your Cryo-EM and X-Ray Crystallography projects and find out how we can help accelerate your results, drop us a message to book a slot 📥 #CryoEM #StructureBasedDrugDesign #StructuralBiology #DrugDesign #XrayCrystallography #TherapeuticTargets #DrugDevelopment

Our new resource manuscript has been published in the Journal of Medicinal Chemistry! This paper marks a significant milestone in the WDR project at SGC, showcasing the results of an exciting collaboration between X-Chem, Inc., Relay Therapeutics, Google, and our team. Our study presents a pilot hit-finding campaign using DNA-encoded chemical library selection followed by Machine Learning (DEL-ML) methodology applied to discover ligands targeting WD-containing proteins — a critical area in protein function and disease modulation. As part of this project, I had the privilege of designing and optimizing a range of biophysical assays (HTRF, FP, SPR, DSF, ITC) and screening vast compound libraries from X-Chem, Inc., Google, and Relay Therapeutics against three key target proteins: RFWD3, RFWD2, and RBBP4. A huge thank you to all the incredible scientists across various disciplines who contributed to this project. Check out the full paper here: https://lnkd.in/eB_Ed7sx #Biophysics #MedicinalChemistry #CollaborativeScience #TargetDiscovery #ProteinScience #HitID