A randomized clinical trial comparing two types of surgery in people with localized muscle-invasive bladder cancer found that more extensive surgery removing a larger group of lymph nodes did not improve survival, compared with standard lymph node surgery. https://go.nih.gov/3cmt6vK Media Description: Lymphadenectomy in people with bladder cancer can range from a limited dissection (only lymph nodes in the light red region) to a super-extended dissection (lymph nodes in the red, blue, yellow, purple, green regions). Credit: Journal of Clinical Medicine. August 2024. https://lnkd.in/dSTzkeKT. CC BY 4.0.
Francisco T.
6d
El estudio refuerza lo que ya se ha observado en diversas áreas de la medicina: mientras menos invasiva sea la cirugía, mejor es el resultado para el paciente en términos de calidad de vida y recuperación. En este caso, queda claro que una cirugía más extensa para extirpar ganglios linfáticos adicionales no aporta beneficios significativos en la supervivencia de pacientes con cáncer de vejiga con invasión muscular. Esto respalda la importancia de personalizar los tratamientos y evitar procedimientos innecesarios que no solo no mejoran los resultados, sino que pueden aumentar los riesgos asociados a la cirugía.
Digital Transformation & Analytics | MBA in Marketing & Analytics
6dCan't really comment on this one absent really in depth familiarities with the intricacies of the pathophysiologies in progressions here Center to consideration here would be what the role of the additional lymph nodes is here - are they conduits to further metastases, if yes with rapidity thatd explain the seeming no benefit as these things are often race conditions, if no or where that's like last of problems then thatd explain the lack of benefit Who knows sometimes even malignant lymph nodes might still be adding something to the mixes mixing in Also would have to know the treatment modalities and their efficacies with it - often these sorts of interventions only deliver lifts when tx modalities are synergy like immune chemorx etc. The science makes complete sense for why that is but even then all boils down to the intricacies familiarities with the subtleties of this particular pathogenesis Even surface level macro seeming science like when you drastically decrease number of replicating cells with surgical means- like 90% plus and are treating with a modality prone to resistance formation - needless to say do a number on the likelihood and rapidity of such resistances forming as they are functions of replication