NervGen Pharma Corp.’s Post

New to small molecule microarrays? Our article in IBI Journal gives an accessible overview of their history, process, and drug discovery applications. Read the full text here » https://lnkd.in/eVU9XttQ #highthroughputscreening #smallmolecule #drugdiscovery #microarray Arrayjet authors: Adam Buckle, Iain McWilliam, Julia Stefanie Renate Unsicker.

I have posted my thoughts about this panel discussion on my blogs. Please check them out at https://lnkd.in/gYyMytwe and https://lnkd.in/gFMEswTx. Key takeaways: 1. AI’s impact on drug discovery: The discussion highlighted AI’s potential in significantly reducing drug discovery time, as evidenced by Dr. Jin-Geon Bae’s experience of reducing a process from 3 years to 3 months. 2. Communication is Crucial: Efficient communication based on mutual respect among researchers with diverse backgrounds is essential for successful collaboration in AI-driven drug discovery projects. 3. Market Focus: There were varied strategies on whether to prioritize global markets or establish a strong domestic presence first, reflecting diverse business models and market conditions among companies.

Why are #organoids becoming increasingly popular in drug discovery, and how can you integrate these powerful cell models into your research? Our Essential Guide to Organoids in Drug Discovery is your go-to resource. It covers the history, current role, and future impact of organoids in drug discovery. You'll discover how organoids can be used across various applications and how new technologies are breaking down barriers to using these models in the #drugdiscovery process. Read more: https://lnkd.in/eE5jYpyE

A fantastic series about high throughput screening strategies. #drughunting #MedicinalChemistry #ResearchNeverStops #Evotec #discovery #development #manufacturing #DMPK #drugdiscovery #pharma ADME #Toxicology #biotech #lifesciences #RnD #oncology #cancer #alzheimersdisease #immunology #cardiovascular #inflammation #CNS #neurodegeneration #infectiousdiseases #autoimmunedisease #cellandgenetherapy #iPSCs #proteomics #degraders #genetics #stratification #personalization

📢 I am thrilled to share Axxam latest publication: "The development of a novel high-throughput membrane potential assay and a solid-supported membrane (SSM)-based electrophysiological assay to study the pharmacological inhibition of GLUT9/SLC2A9 isoforms in a drug discovery program". This work introduces innovative methodologies to investigate the pharmacological modulation of GLUT9/SLC2A9 isoforms, key players in urate transport and metabolic disorders. By combining a high-throughput membrane potential assay with an SSM-based electrophysiological approach, we’ve created robust tools for advancing drug discovery efforts in this area. A huge thank you to the incredible team behind this achievement! 🙌 📖 Read the full paper here: https://lnkd.in/ei85xSNN Let’s continue to push the boundaries of innovation in drug discovery! #DrugDiscovery #HTS #MembranePotential #Innovation #Science

Curious to learn about hit identification and high throughput screening strategies at Evotec? Join our 5-part webinar series now. The first 3 episodes are already available on demand, while new episodes in September and October are open for registration now. Overview of the episodes: #1: Unlocking High Throughput Hit Identification Strategies, with Thomas Ahrens #2: It All Starts With a Protein – Protein Sciences as a Key to Success in Drug Discovery, with James Errey #3: Molecular Interactions Matter - Biophysical Screening for Early Drug Discovery, with Florian Krieger #4: The Role of Structural Insights in Drug Discovery, with Jay Bertrand #5: Illuminating Cellular Processes through High Content Methods, with Karsten Kottig and Sven Schreiter To find more information, and to get access to the individual sessions, please visit: https://hubs.ly/Q02H5HRr0 #researchneverstops #Evotec #drugdiscovery

Come see and hear what's happening in New Molecular Modality Drug Discovery!

"Make or break questions for a drug discovery project often come down to, “does modulating this target do what we want?” and, “what else does modulating this target do?” In order to answer those questions quickly and make drug discovery decisions with confidence, an understanding of target engagement and corresponding on- and off-target effects on biology is critical. " https://lnkd.in/g3W2gTN5 #drugdiscovery #drugdelivery #decisiontools

In this short movie, you can clearly observe the microstreaming flow around the microbubbles. I invite you to watch and listen carefully. 🎤Presenter: Professor Ayache Bouakaz ⏱️In Scientific session Non-ionising radiation: Ultrasound-mediated drug delivery Title: Recent advances in ultrasound-mediated drug delivery: Insights from preclinical and clinical trials. #MicrostreamingFlow #Microbubbles #UltrasoundMechanics #DrugDelivery #ScientificSession #UltrasoundResearch #ClinicalTrials

Apop is pleased to announce the release of its powerful autophagy imaging reagent, CalRexin®:pHrodo™ Red. CalRexin®:pHrodo™ Red is a first-in-class imaging reagent that identifies a novel marker of autophagy, namely activated calcitonin receptor. CalRexin®:pHrodo™ Red resists photobleaching and is extremely stable, properties that are essential for high throughput/content imaging of live cells over 24 hours at multiple timepoints. Unlike alternatives, CalRexin®:pHrodo™ Red passes through sequential structures of the autophagy pathway from early endosomes to autolysosomes where it fluoresces brightly in the low pH environment, illuminating multiple components of the autophagic process, in real time. CalRexin®:pHrodo™ Red provides exceptional, high-fidelity data and is utilised for primary screening of autophagy-modulating compounds from small molecule libraries on high throughput/content platforms, invaluable for drug discovery. All Apop products are for Research Use Only (RUO). Not for diagnostic or therapeutic use. pHrodo™ is a registered trademark of Thermo Fisher Scientific. #biotech #imagingreagent #bioscience